Laboratory Specialty Services
Selleck Chemical LLC SGI-1027
SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6 8 7 5 M for DNMT1 DNMT3A and DNMT3B in cell-free assays respectively SGI 1027 induces apoptosis
Apexbio Technology LLC SGI-1027 1020149-73-8 10mM (in 1mL DMSO)
SGI-1027 (CAS 1020149-73-8) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) exhibiting IC50 values of 12 5 M for DNMT1 8 M for DNMT3A and 7 5 M for DNMT3B It acts by competitively inhibiting the cofactor Ado-Met binding site rather than the DNA substrate site resulting in reduced DNMT activity and subsequent inhibition of DNA methylation SGI-1027 suppresses both mammalian and bacterial DNMTs affecting endogenous and recombinant forms In cancer cell models it induces demethylation of CpG islands in gene promoter regions leading to reactivation of silenced tumor suppressor genes such as P16 and TIMP3 and promotes DNMT1 degradation via the proteasome pathway SGI-1027 is utilized in epigenetics research to study DNA methylation dynamics and gene reactivation
Cambridge Isotope Laboratories RoHS PBDE Calibration Solutions (CS1-CS5) 5 x 0 2 mL
RoHS PBDE Calibration Solutions (CS1-CS5) 5 x 0 2 mL
Cambridge Isotope Laboratories PCB Calibration Solutions (CS1-CS5) 5 x 200 uL
PCB Calibration Solutions (CS1-CS5) 5 x 200 uL
Hampton Research HR2-928-D2/Grid Screen PEG/LiCl #D2, 185 ml - 0.1 M Citric acid pH 5.0, 1.0 M Lithium chloride, 30% w/v Polyethylene glycol 6,000
HR2-928-D2/Grid Screen PEG/LiCl #D2, 185 ml - 0.1 M Citric acid pH 5.0, 1.0 M Lithium chloride, 30% w/v Polyethylene glycol 6,000. Please note items from this supplier are non-returnable.
Hampton Research HR2-939-07/StockOptions Sodium Cacodylate #07 pH 5.7, 185 ml
HR2-939-07/StockOptions Sodium Cacodylate #07 pH 5.7, 185 ml. Please note items from this supplier are non-returnable.
Hampton Research HR2-939-22/StockOptions Sodium Cacodylate #22 pH 7.2, 185 ml
HR2-939-22/StockOptions Sodium Cacodylate #22 pH 7.2, 185 ml. Please note items from this supplier are non-returnable.
Hampton Research HR2-939-18/StockOptions Sodium Cacodylate #18 pH 6.8, 185 ml
HR2-939-18/StockOptions Sodium Cacodylate #18 pH 6.8, 185 ml. Please note items from this supplier are non-returnable.
Hampton Research HR2-939-06/StockOptions Sodium Cacodylate #06 pH 5.6, 185 ml
HR2-939-06/StockOptions Sodium Cacodylate #06 pH 5.6, 185 ml. Please note items from this supplier are non-returnable.
Cambridge Isotope Laboratories PCN Calibration Solutions (CS1-CS7) 7 x 0 5 mL
PCN Calibration Solutions (CS1-CS7) 7 x 0 5 mL
Hampton Research MEMBFAC NO21 185ML
HR2-920-21/MembFac #21 (B9), 185 ml - 0.1 M Lithium sulfate monohydrate, 0.1 M Sodium citrate tribasic dihydrate pH 5.6, 4% v/v Polyethylene glycol 400. Please note items from this supplier are non-returnable.
Hampton Research MEMBFAC NO01 185ML
HR2-920-01/MembFac #01 (A1), 185 ml - 0.1 M Sodium chloride, 0.1 M Sodium acetate trihydrate pH 4.6, 12% v/v (+/-)-2-Methyl-2,4-pentanediol. Please note items from this supplier are non-returnable.
Hampton Research MEMBFAC NO23 185ML
HR2-920-23/MembFac #23 (B11), 185 ml - 0.1 M Lithium sulfate monohydrate, 0.1 M ADA pH 6.5, 12% w/v Polyethylene glycol 4,000, 2% v/v 2-Propanol. Please note items from this supplier are non-returnable.