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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Licochalcone D (Lico D LCD LD) a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata has antioxidant anti-inflammatory and anti-cancer properties Licochalcone D inhibit phosphorylation of NF- B p65 in LPS signaling pathway Licochalcone D inhibits JAK2 EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage
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Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Sodium Glucuronic Acid (4-FLUOROCINNAMONITRILE) is used in the treatment of hepatitis and liver cirrhosis. Purity 99.53%
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ODN D-SL03 sodium is a C class CpG oligonucleotide that stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It can activate human B cells, NK cells, and mononuclear cells, leading to the upregulation of CD80, CD86, and HLA-DR expression on the surface of subsets in human PBMCs. This oligonucleotide also demonstrates tumor growth inhibition.
Stimulates PBMCs to produce high levels of IFN-α
Activates human B cells, NK cells, and mononuclear cells
Upregulates expression of CD80, CD86, and HLA-DR on the surface of subsets in human PBMCs
Demonstrates tumor growth inhibition
Sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'
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N-Acetylneuraminic acid (131-48-6) is a monosaccharide located at the terminal positions of glycoproteins on mammalian cell membranes It modulates cell signaling adhesion and recognition processes by altering glycoconjugate structures N-Acetylneuraminic acid exerts its biological activity primarily through regulation of sialylation patterns on surface glycoproteins which influence tumor cell proliferation adhesion dynamics and metastatic potential Key metric values such as IC50 vary significantly depending on the biological model and assay conditions Based on these properties N-Acetylneuraminic acid holds research potential in tumor biology cardiovascular injury models lipid metabolism disorders and studies of membrane protein interactions and tumor metastasis
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D-α-Tocopherylquinone is a quinone isolated from *Phaeodactylum tricornutum* and an oxidation product of α-Tocopherol (vitamin E). It functions as an anticoagulant and antioxidant, actively reducing cellular oxidative damage caused by oxidized lipids. The compound binds to a liver cytosolic protein (molecular mass ~40 kDa) and to glutathione-S-transferase (GST), which aids its transport to metabolism sites or excretion in bile.
Isolated from *Phaeodactylum tricornutum*
Oxidation product of α-tocopherol (vitamin E)
Acts as an anticoagulant
Acts as an antioxidant
Reduces cellular oxidative damage from oxidized lipids
Binds to a liver cytosolic protein
Binds to glutathione-S-transferase (GST)
Facilitates transport for metabolism or excretion
Inhibits GST activity dose-dependently
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Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2 microM. Purity 99.94%
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