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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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SynuClean-D is a small-molecule inhibitor of α-synuclein aggregation used in research to disrupt amyloid fibrils and inhibit fibril propagation; it has shown neuroprotective effects in Parkinson's disease models.
Inhibits α-synuclein aggregation in vitro.
Disrupts mature amyloid fibrils.
Prevents fibril propagation and seeding.
Reduces dopaminergic neuron degeneration in animal models.
Available as a 10 mM solution in DMSO and in multiple solid quantities.
High assay purity (≈99.9%).
Molecular formula C13H5F3N4O5, molecular weight 354.20 g/mol.
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SIRP-beta (Sirpb CD172b) is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins Sirpb was found to interact with TYROBP/DAP12 a transmembrane adaptor protein bearing immunoreceptor tyrosine-based activation motifs resulting in the tyrosine phosphorylation of DAP12 and the subsequent recruitment of Syk to the Sirpb-DAP12 complex Sirpb is also implicated as a positive regulator of hematopoietic cells SIRP beta Protein Mouse (HEK293 His) is the recombinant mouse-derived SIRP beta protein expressed by HEK293 with C-His labeled tag
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The SP-D protein plays a critical role in the lung s defense mechanisms against inhaled microorganisms organic antigens and toxins This multifunctional protein interacts with a variety of compounds including bacterial lipopolysaccharides oligosaccharides and fatty acids to modulate leukocyte activity in immune responses SP-D Protein Rhesus Macaque (HEK293 His) is the recombinant Rhesus Macaque-derived SP-D protein expressed by HEK293 with C-His labeled tag
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N-Acetylneuraminic acid (131-48-6) is a monosaccharide located at the terminal positions of glycoproteins on mammalian cell membranes It modulates cell signaling adhesion and recognition processes by altering glycoconjugate structures N-Acetylneuraminic acid exerts its biological activity primarily through regulation of sialylation patterns on surface glycoproteins which influence tumor cell proliferation adhesion dynamics and metastatic potential Key metric values such as IC50 vary significantly depending on the biological model and assay conditions Based on these properties N-Acetylneuraminic acid holds research potential in tumor biology cardiovascular injury models lipid metabolism disorders and studies of membrane protein interactions and tumor metastasis
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