Lipids and Lipid Derivatives
Medchemexpress LLC TAT-QFNP12 acetate | 3006.47 (free base) | 1 MG
TAT-QFNP12 acetate is a peptide that plays a crucial role in cellular signaling pathways. It functions by blocking the NDRG2-PPM1A binding, which in turn reduces Smad2/3 phosphorylation. This peptide is also known to decrease astrocytic MMP-9 production and mitigate blood-brain barrier (BBB) disruption following subarachnoid hemorrhage (SAH).
- Blocks NDRG2-PPM1A binding
- Reduces Smad2/3 phosphorylation
- Decreases astrocytic MMP-9 production
- Mitigates blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH)
Medchemexpress LLC Vinorelbine-d3 (ditartrate) | 125317-39-7 | 98.0% | 1082.12 | 100 UG
Vinorelbine-d3 ditartrate is a deuterium labeled version of Vinorelbine ditartrate, an anti-mitotic agent that inhibits the proliferation of Hela cells with an IC50 of 1.25 nM. This compound serves as a valuable tracer and internal standard for quantitative analysis in various analytical techniques.
- Deuterium labeled compound for precise research.
- Inhibits Hela cell proliferation, acting as an anti-mitotic agent.
- Functions as a tracer in drug development processes.
- Ideal as an internal standard for NMR, GC-MS, or LC-MS quantitative analysis.
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Protirelin acetate | 120876-23-5 | 99.9% | 452.46 | 1 ML
Protirelin acetate is a highly conserved neuropeptide that plays a crucial role in the hormonal regulation of thyroid-stimulating hormone (TSH) levels, in addition to exhibiting neuromodulatory functions. It is an evolutionarily ancient neuropeptide, with origins predating the divergence of protostomes and deuterostomes, and may have historically been involved in controlling postembryonic growth and reproduction.
- Investigated for its effect on body temperature in rats.
- Causes a temporary, dose-dependent rise in body temperature in male Wistar rats.
- The hyperthermic action may involve the release of thyroid hormone.
- Thyroidectomized rats do not show a rise in body temperature when administered Protirelin.
Medchemexpress LLC HY-112847A 5mg Medchemexpress, Sulfosuccinimidyl oleate sodium CAS: Purity:>98%
Medchemexpress, HY-112847A 5mg Sulfosuccinimidyl oleate sodium CAS: Sulfosuccinimidyl oleate sodium is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC ACTH (11-24) acetate | 99.88% | 1652.04 | 10 MG
ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. It is a fragment of adrenocorticotropic and induces cortisol release. This compound can be used for research of the central nervous system. In vitro, ACTH (11-24) (acetate) elicits cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells, and in vivo, it has slight influences on circulating plasma corticosterone values and on fighting behavior.
- Adrenocorticotropic hormone (ACTH) receptor antagonist
- Induces cortisol release
- Suitable for research of the central nervous system
- Purity of 99.88%
- Molecular weight of 1652.04 (free base)
Medchemexpress LLC Aminoadipic acid-d3 | 2483832-01-3 | 99.1% | 164.17 | 10 MG
Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid, an intermediate in the metabolism of lysine and saccharopine. Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Apexbio Technology LLC Uridine triacetate 4105-38-8 200mg
Uridine triacetate is an orally bioavailable prodrug of uridine It is designed to undergo rapid intestinal absorption followed by enzymatic deacetylation in circulation thereby releasing free uridine Uridine triacetate exerts its biological activity primarily through metabolic conversion to uridine which supports studies of systemic toxicity induced by chemotherapeutic agents such as 5-fluorouracil (5-FU) and capecitabine Based on these pharmacological properties uridine triacetate holds research potential in examining mechanisms underlying chemotherapy-induced cardiac and central nervous system toxicity as well as in studying metabolic events related to uridine homeostasis and therapeutic intervention following drug overdose or excessive chemotherapeutic exposure
Apexbio Technology LLC Bazedoxifene acetate 198481-33-3 50mg
Bazedoxifene acetate (CAS 198481-33-3) is a selective estrogen receptor modulator (SERM) targeting estrogen receptors (ER) It is designed to modulate ER activity thereby regulating estrogen-dependent cellular pathways Bazedoxifene acetate exerts its biological activity primarily through tissue-specific agonism and antagonism of ER In in vitro studies Bazedoxifene acetate demonstrates receptor modulation with reported affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene acetate holds research potential in osteoporosis and bone metabolism studies as well as in investigations of hormone-responsive cellular mechanisms and pancreatic cancer
Cambridge Isotope Laboratories 1 2-Dihexanoyl-SN-glycero-3-phosphocholine (DH6PC) (hexanoyl-D22 97% 50-60% on Alpha carbons) 0 1 g
1 2-Dihexanoyl-SN-glycero-3-phosphocholine (DH6PC) (hexanoyl-D22 97% 50-60% on Alpha carbons) 0 1 g
TARGETMOL CHEMICALS INC beta-Amyrin acetate 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 uM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities. Purity 99.74%
Medchemexpress LLC L-Palmitoylcarnitine chloride | 18877-64-0 | 99.9% | 436.07 | 10 MG
L-Palmitoylcarnitine chloride is a long-chain acylcarnitine and a fatty acid metabolite. It accumulates in the sarcolemma and deranges the membrane lipid environment during ischemia. This compound inhibits KATP channel activity without affecting the single channel conductance, through interaction with Kir6.2. It also simultaneously enhances the ATP sensitivity of the channel.
- Long-chain acylcarnitine and fatty acid metabolite
- Accumulates in sarcolemma and deranges membrane lipid environment during ischaemia
- Inhibits KATP channel activity
- Interacts with Kir6.2