Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). It is a white to off-white solid that acts as a catecholamine neurotransmitter. This compound is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain, playing several important roles through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. It is suitable for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.