Solvents
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide Reagent
Dimethyl sulfoxide is an amphipathic molecule soluble in both aqueous and organic solvents. It is commonly used as an aprotic solvent and also as a reagent in organic synthesis.
Medchemexpress LLC O-Toluic acid-13C | 70838-82-3 | 99% | 137.14 | 100 MG
o-Toluic acid-13C is the 13C labeled o-Toluic acid, which is a benzoic acid substituted by a methyl group at position 2. It functions as a xenobiotic metabolite and is intended for research use only. This compound is valuable as a tracer and an internal standard in quantitative analysis.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 4-butylphenol-d5 | 1219795-04-6 | 98.0% | 155.25 g·mol^-1 | C10H9D5O | 10 MG
4-Butylphenol-d5 is a deuterium-labeled analogue of 4-butylphenol used as an isotopically labeled standard or tracer in analytical and research applications. It is supplied in small, research-scale quantities for laboratory use and intended for scientific research only.
- Deuterium-labeled compound suitable as an internal standard in mass spectrometry.
- High reported purity for reliable analytical performance.
- Molecular formula provided to support quantitation and identification.
- Available in small, convenient pack sizes for research workflows.
Medchemexpress LLC Acetylcholine-d9 chloride | 344298-95-9 | 99.0% | 1 MG
Acetylcholine-d9 chloride is a deuterium-labeled acetylcholine chloride, which is a potent, BBB-permeable cholinergic agonist. This neurotransmitter modulates the activity of dopaminergic neurons by stimulating nicotinic acetylcholine receptors and inhibits p53 mutant peptide aggregation in vitro. It can be utilized as a tracer or an internal standard for quantitative analysis through techniques like NMR, GC-MS, or LC-MS.
- Deuterium-labeled acetylcholine chloride
- Potent and BBB-permeable cholinergic agonist
- Modulates dopaminergic neuron activity
- Inhibits p53 mutant peptide aggregation in vitro
- Suitable as a tracer or internal standard for quantitative analysis
Apexbio Technology LLC Sodium Picosulfate 10040-45-6 10mM (in 1mL DMSO)
Sodium picosulfate is an organic stimulant laxative widely utilized to investigate bowel motility and electrolyte balance Its pharmacological activity involves inhibition of fluid and electrolyte absorption alongside enhancement of their secretion in the intestinal lumen thus promoting bowel evacuation In vitro studies evaluating human rat and rabbit liver cell cultures showed sodium picosulfate interaction with hepatic cells notably rabbit hepatocytes demonstrated higher sensitivity reflected by decreased cellular protein content at concentrations in the g/ml range Clinical research supports the utility of sodium picosulfate in experimental constipation models including drug-induced and chronic constipation settings allowing assessment of bowel function and symptoms such as abdominal distension and stool consistency
Apexbio Technology LLC Atglistatin 1469924-27-3 10mM (in 1mL DMSO)
Atglistatin (CAS 1469924-27-3) is a small-molecule inhibitor selective for adipose triglyceride lipase (ATGL) an enzyme that catalyzes the rate-limiting step in triglyceride hydrolysis releasing fatty acids from cellular triglyceride stores Atglistatin inhibits ATGL activity competitively with an IC50 of 0 7 M and Ki of 355 nM In mouse white adipose tissue lysates atglistatin decreased triglyceride hydrolase activity by approximately 78% effectively reducing fatty acid and glycerol release This compound serves as a valuable tool in lipid metabolism and metabolic disease research
Apexbio Technology LLC Rifaximin (Xifaxan) 80621-81-4 10mM (in 1mL DMSO)
Rifaximin (Xifaxan) a rifamycin derivative is a nonabsorbable antibiotic targeting bacterial RNA synthesis by binding to the -subunit of bacterial DNA-dependent RNA polymerase In vitro rifaximin also functions as an intestinal-specific agonist for human pregnane X receptor (PXR) modulating intestinal immune responses Rifaximin (EC50 20 M) activates human PXR reducing inflammatory cytokine expression induced by LPS in human colonic biopsies In animal models rifaximin alters intestinal expression of PXR-responsive genes relevant to drug metabolism and lipid homeostasis Clinically rifaximin has been utilized in research on hepatic encephalopathy and irritable bowel syndrome (IBS)
eMolecules Broadpharm / Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid / 100mg / 210965538 / BP-21710 / 98.000 / 1446282-17-2 / MFCD25424119 / 466.401 / C16H36O11P2
Broadpharm / Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid / 100mg / 210965538 / BP-21710 / 98.000 / 1446282-17-2 / MFCD25424119 / 466.401 / C16H36O11P2
Apexbio Technology LLC Dacomitinib (PF299804, PF299) 1110813-31-4 10mM (in 1mL DMSO)
Dacomitinib (PF299804 CAS 1110813-31-4) is an irreversible pan-HER small-molecule inhibitor that targets the epidermal growth factor receptor (EGFR/ErbB-1) ERBB2 (HER2) and ERBB4 (HER4) It acts by covalently binding EGFR family tyrosine kinases inhibiting downstream signaling through phospho-HER family proteins AKT and ERK Dacomitinib shows activity in vitro inducing G0/G1 cell cycle arrest and apoptosis and suppresses proliferation in trastuzumab- or lapatinib-resistant HER2-amplified breast cancer cell lines In vivo studies demonstrate antitumor effects in EGFR-mutant (e g T790M) gefitinib-resistant lung cancer xenografts making it relevant for non-small cell lung cancer research
Medchemexpress LLC N,N-dimethylformamide dimethyl acetal | 4637-24-5 | MFCD00008482 | 97.0% | 119.16 g/mol | C5H13NO2 | 250g
1 1-Dimethoxy-N N-dimethylmethanamine (N-Dimethoxymethyl-N N-dimethylamine) is a biological molecule
Medchemexpress LLC L-cysteine-13C3,15N | 202406-97-1 | MFCD01073449 | 99.9% | 125.13 | 13C3H7 15NO2S | 50mg
L-Cysteine-13C3 15N is the 13C- and 15N-labeled L-Cysteine L-Cysteine is a conditionally essential amino acid which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S) glutathione and taurine L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1]
Apexbio Technology LLC Atomoxetine HCl 82248-59-7 10mM (in 1mL DMSO)
Atomoxetine HCl (CAS 82248-59-7) is a selective inhibitor of the norepinephrine transporter (NET) a membrane protein responsible for norepinephrine reuptake and synaptic homeostasis Atomoxetine shows high selectivity towards human NET (Ki 5 nM) with substantially lower affinity for serotonin (Ki 77 nM) and dopamine transporters (Ki 1451 nM) In preclinical studies using rat models atomoxetine elevated extracellular norepinephrine and dopamine specifically in the prefrontal cortex region without affecting dopamine levels in the striatum or nucleus accumbens These traits render it useful in research on neurotransmitter regulation related to cognition and attention disorders
Cayman Chemical DopamIn-d4hydrochlorIde 25mg
An internal standard for the quantification of dopamine by GC- or LC-MS