Solvents
American Radiolabeled Chemicals Inc PITAVASTATIN 3-3H 50UC
Pitavastatin-3-3H 50uCi in ethanol, 1 mCi/ml, 20-30 Ci/mmol, M.W. 421.46, Shipped in Dry Ice, Exclusive
American Radiolabeled Chemicals Inc PRAVASTATIN 3HG CA 50UC
Pravastatin-3H(G) calcium salt 50uCi in ethanol:water (1:1), 1 mCi/ml, 10-20 Ci/mmol, M.W. 887.14, Shipped in Dry Ice, Exclusive
Apexbio Technology LLC Andarine 401900-40-1 10mM (in 1mL DMSO)
Andarine (S-4) is a selective androgen receptor (AR) antagonist with a Ki value of approximately 4 nM indicating strong receptor-binding affinity It functions by selectively targeting androgen receptors nuclear receptors involved in DNA-mediated transcription and gene expression regulation In vitro studies using AR-driven transcription assays illustrate Andarine s capacity to modulate AR activity at nanomolar concentrations Animal model studies in male Sprague-Dawley rats suggest Andarine administration induces a dose-dependent increase in tissues responsive to androgen activity including prostate gland seminal vesicles and levator ani muscle Due to its receptor specificity and manageable pharmacodynamics Andarine is widely investigated in biomedical research related to androgen receptor signaling pathways endocrine regulation and therapeutic responses involving AR-mediated mechanisms
Cayman Chemical AcetamIprId-d3 1mg
An internal standard for the quantification of acetamiprid by GC- or LC-MS
Apexbio Technology LLC Levetiracetam 102767-28-2 10mM (in 1mL DMSO)
Levetiracetam (CAS 102767-28-2) is an antiepileptic small-molecule agent recognized for its distinct mode of action compared to traditional anticonvulsants It binds selectively to synaptic vesicle glycoprotein 2A (SV2A) a protein involved in the regulation of intracellular calcium dynamics and neurotransmitter release Mechanistically levetiracetam negatively modulates gamma-aminobutyric acid (GABA)- and glycine-gated neuronal currents Importantly levetiracetam does not induce hepatic cytochrome P450 enzymes exhibits negligible plasma protein binding and is predominantly excreted unchanged renally with partial hydrolytic metabolism clinically levetiracetam is utilized widely in research addressing partial and generalized epileptic seizures
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Medchemexpress LLC Oxybutynin-d11 chloride | 1185151-95-4 | 97.4% | 5 MG
Oxybutynin-d11 (chloride) is the deuterium-labeled version of Oxybutynin chloride. Oxybutynin chloride acts as an anticholinergic agent, inhibiting vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM. Deuterium substitution, as seen in this product, has been studied for its potential to alter the pharmacokinetic and metabolic profiles of drugs.
- It is a deuterium-labeled compound.
- It serves as a tracer.
- It can be used as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS.
- It is intended for research use only.
Apexbio Technology LLC Chlorocresol 10mM (in 1mL DMSO)
B1696 is a small molecule compound utilized in biomedical research primarily due to its modulatory effects on specific cellular signaling pathways Although the explicit molecular target is currently unpublished available evidence indicates that B1696 influences cellular processes implicated in inflammation immune response and cell proliferation Researchers employ this compound to investigate disease mechanisms and signaling networks within in vitro or ex vivo experimental systems contributing valuable information on therapeutic intervention strategies and drug development efforts
Apexbio Technology LLC STF-62247 315702-99-9 10mM (in 1mL DMSO)
STF-62247 (CAS 315702-99-9) is a small molecule that selectively targets renal cell carcinoma (RCC) cells carrying von Hippel-Lindau (VHL) gene deletions It exhibits cytotoxicity in both wild-type and VHL-deficient RCC cells via a mechanism independent of hypoxia-inducible factor (HIF) with reported IC50 values of 16 M and 0 625 M respectively In VHL-deficient RCC cells STF-62247 induces acidification autophagy and subsequent apoptotic cell death In mouse xenograft models bearing VHL-deficient SN12C tumors STF-62247 significantly reduced tumor growth This compound is useful for studying therapeutic strategies targeting VHL-deficient tumors
Apexbio Technology LLC LDC1267 1361030-48-9 10mM (in 1mL DMSO)
LDC1267 (CAS 1361030-48-9) is a selective inhibitor of the TAM receptor tyrosine kinases Mer Tyro3 and Axl demonstrating IC50 values of less than 5 nM 8 nM and 29 nM respectively By inhibiting TAM signaling LDC1267 abolishes Gas6-mediated suppression in NKG2D-activated natural killer (NK) cells thus enhancing NK-mediated cytotoxicity Preclinical studies show reduced metastasis of melanoma and 4T1 breast tumor cells upon LDC1267 administration in mouse models an effect reliant on NK cell function LDC1267 provides a research tool for investigating TAM-regulated immune modulation in cancer models
Apexbio Technology LLC Salubrinal 405060-95-9 10mM (in 1mL DMSO)
Salubrinal is a cell-permeable inhibitor of eukaryotic translation initiation factor 2 alpha (eIF2 ) dephosphorylation exhibiting an IC50 of approximately 15 M It prevents phosphatase complexes from removing phosphate groups from eIF2 thus maintaining its phosphorylated state and modulating protein synthesis during cellular stress responses Salubrinal is utilized experimentally in vitro to investigate apoptotic mechanisms related to endoplasmic reticulum (ER) stress For instance it provides cytoprotection against ER stress-induced apoptosis triggered by protein glycosylation inhibitors or ER-Golgi trafficking inhibitors In vivo murine models employ salubrinal to explore cellular processes underlying oxidative stress and nephrotoxicity induced by chemotherapeutic treatments through modulation of ER stress-associated apoptosis signaling pathways Currently no clinical trials involving salubrinal have been reported
Cayman Chemical Enobosarm-d4 1mg
An internal standard for the quantification of enobosarm by GC- or LC-MS
Cayman Chemical CapsaIcIn-d3 1mg
An internal standard for the quantification of capsaicin by GC- or LC-MS
Apexbio Technology LLC Pepstatin A 26305-03-3 10mM (in 1mL DMSO)
Pepstatin A is a pentapeptide functioning as an inhibitor targeting aspartic proteases including pepsin renin HIV protease and cathepsin D It inhibits human renin and HIV protease with IC50 values of approximately 15 M and 2 M respectively and shows inhibitory activity toward pepsin and cathepsin D at IC50 values below 5 M and 40 M Mechanistically Pepstatin A acts through binding to the catalytic site of aspartic proteases restricting proteolytic activity In biomedical research it is utilized to study viral protein processing osteoclast differentiation mediated by cathepsins and as a standard tool in enzyme inhibition assays examining aspartic protease function
Medchemexpress LLC Nortriptyline hydrochloride | 894-71-3 | 99.98% | 1 G
Nortriptyline (Desmethylamitriptyline) hydrochloride is the main active metabolite of Amitriptyline and acts as a tricyclic antidepressant. It is also a potent autophagy inhibitor and has anticancer effects.
- Main active metabolite of Amitriptyline
- Tricyclic antidepressant
- Potent autophagy inhibitor
- Has anticancer effects