Fatty alcohol esters
Medchemexpress LLC DT-2 acetate | 98.6% | 3761.25 | 1 MG
DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG), which inhibits PKG catalyzed phosphorylation with a Ki of 12.5 nM.
- Potent and selective inhibitor of cGMP-dependent protein kinase (PKG).
- Inhibits PKG catalyzed phosphorylation.
- For research use only.
Medchemexpress LLC RVG-Cys acetate | 99.7% | 3369.77 (free acid) | 10 MG
RVG-Cys (RVG29-Cys) acetate is a peptide derived from rabies virus glycoprotein (RVG29) with Cys attached to facilitate subsequent conjugation. It enhances the specific targeted delivery of proteins in brain tissue and neurons.
- Peptide derived from rabies virus glycoprotein (RVG29)
- Includes Cys for subsequent conjugation
- Enhances specific targeted delivery of proteins
- Delivers to brain tissue and neurons
Medchemexpress LLC DT-2 acetate | 98.6% | 3761.25 | 10 MG
DT-2 acetate is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). It inhibits PKG catalyzed phosphorylation with a Ki of 12.5 nM. This product has a molecular weight of 3761.25 and a purity of 98.6%.
- Potent and selective inhibitor of cGMP-dependent protein kinase (PKG)
- Inhibits PKG catalyzed phosphorylation with a Ki of 12.5 nM
- Molecular weight: 3761.25
- Purity: 98.6%
Medchemexpress LLC Cigb-300 (acetate) | 98.0% | 3060.60 | 1 MG
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research.
- Exhibits anticancer properties
- Interferes with phosphorylation of protein kinase CK2
- Induces apoptosis in multiple tumor cell lines
- Useful in cancer research
Medchemexpress LLC 1-O-n-Octyl-B-D-gluc 1mg | 129522-81-2 | 309.47 g·mol^-1 | C14H11D17O6 | 1 MG
Deuterated n-octyl β-D-glucopyranoside (d17) is a deuterium-labeled non-ionic detergent used to solubilize membrane proteins and as an analytical standard in quantitative methods. It is supplied in small, research-scale quantities for biochemical and analytical workflows.
- Deuterium-labeled non-ionic detergent for membrane protein solubilization.
- Serves as a tracer and internal standard for quantitative NMR, GC-MS, and LC-MS.
- Supplied in small, research-grade quantities suitable for analytical use.
- Deuteration provides a mass shift for clear distinction from unlabeled analogs in mass spectrometry.
- Batch-specific certificate of analysis available for purity and isotopic enrichment verification.
Medchemexpress LLC Anrikefon acetate | 2584931-05-3 | 99.7% | 763.97 | 1 MG
Anrikefon acetate is a kappa opioid receptor agonist that exhibits an analgesic effect.
- Kappa opioid receptor agonist
- Exhibits analgesic effect
- Targets opioid receptor
- Involves GPCR/G protein and neuronal signaling pathways
Medchemexpress LLC BMP-4 acetate | 99.30% | 1308.52 (free base) | 50 MG
BMP-4 acetate is a penetrating heparin-binding peptide known for its anti-inflammatory and anti-chondrogenic properties. It operates by modulating the iNOS-IFN-IL6 signaling pathway, which leads to the suppression of inflammatory proteins such as iNOS, COX2, IFN, and IL6. This mechanism helps effectively reduce inflammation and alleviate various arthritis symptoms in both murine chondrocytes and macrophages.
- Penetrating heparin-binding peptide
- Exhibits anti-inflammatory functions
- Exhibits anti-chondrogenic functions
- Regulates the iNOS-IFN-IL6 signaling pathway
- Inhibits expression of inflammatory proteins (iNOS, COX2, IFN, IL6)
- Suppresses inflammation
- Alleviates arthritis symptoms in murine chondrocytes and macrophages
Medchemexpress LLC Lefamulin acetate | 1350636-82-6 | 99.7% | 567.78 | 1 ML
Lefamulin acetate is an orally active antibiotic that inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. It also demonstrates anti-inflammatory activity and is utilized in research pertaining to bacterial infections, such as bacterial pneumonia.
- Inhibits protein synthesis by binding to 50S bacterial ribosome.
- Exhibits anti-inflammatory activity.
- Effective against C. trachomatis, N. gonorrhoeae, and M. genitalium.
- Potent activity against M. pneumoniae strains.
- Shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice.
- Reduces BALF neutrophil cell counts and levels of pro-inflammatory cytokines and chemokines in LPS-induced lung neutrophilia mouse model.
Medchemexpress LLC BMP-4 acetate | 99.3% | 1308.52 | 10 MG
BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. It regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages.
- Penetrating heparin-binding peptide
- Anti-inflammatory and anti-chondrogenic functions
- Regulates iNOS-IFN-IL6 signaling pathway
- Inhibits expression of inflammatory proteins
- Suppresses inflammation and alleviates arthritis symptoms
- Targets IL-6 and COX-2
- Appearance: White to off-white crystal
- Soluble in H2O and DMSO at 100 mg/mL (requires sonication)
Medchemexpress LLC Farnesyl pyrophosphate (ammonium) | 116057-57-9 | 95.4% | 433.42 | 10 MG
Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway and acts as a TRP channel (TRPM2) agonist, triggering Ca2+ influx and cell death. This compound is a critical branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. It is utilized in research concerning cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
- Metabolic intermediate in the mevalonate (MVA) pathway.
- TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death.
- Key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis.
- Used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
Medchemexpress LLC Bimax2 acetate | 98.7% | 3561.98 (free base) | 10 MG
Bimax2 acetate is a high affinity nuclear localization signal (NLS) peptide. It mimics the activity of the classical nuclear localization signal (cNLS) and competitively binds to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. It can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
- High affinity nuclear localization signal (NLS) peptide
- Mimics classical nuclear localization signal (cNLS) activity
- Competitively binds to importin α
- Inhibits binding of cNLS-cargo proteins to importin α
- Useful for studying the role of RBBP4 in regulating nuclear import efficiency and cell senescence
- White to off-white solid
- Soluble in H2O at ≥ 100 mg/mL
- For research use only
Medchemexpress LLC L57 acetate | 99.0% | 2483.87 (free base) | 1 MG
L57 acetate is a Low-density lipoprotein receptor-related protein 1 (LRP1)-binding peptide. It has high affinity to LRP1 with a Ki of 45 nM. It can cross the blood-brain barrier (BBB) and is stable in plasma.
- High affinity to LRP1 (Ki of 45 nM)
- Crosses the blood-brain barrier (BBB)
- Stable in plasma
- Suitable as a carrier for CNS drug delivery
Medchemexpress LLC Cigb-300 acetate | 98.0% | 3060.60 | 10 MG
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide with anticancer properties. It functions by interfering with the phosphorylation of protein kinase CK2 and induces apoptosis in various tumor cell lines, making it suitable for cancer research.
- Anti-casein kinase 2 (CK2) peptide
- Exhibits anticancer properties
- Induces apoptosis in tumor cell lines
- Suitable for cancer research
Medchemexpress LLC PNC-28 acetate | 392661-17-5 | 98.8% | 3509.13 (free acid) | 10 MG
PNC-28 acetate is a peptide derived from the mdm-2-binding domain (residues 17-26) of the p53 protein, incorporating a membrane-crossing-penetratin sequence. This compound is suitable for use in pancreatic cancer research.
- Can be used for pancreatic cancer research
- Blocks growth of a lethal human pancreatic cancer cell line in vitro
- Inhibits BMRPA1. Tuc3 tumor growth in vivo, particularly when delivered directly to the tumor
Medchemexpress LLC MK2-IN-5 acetate (Hsp25 kinase inhibitor acetate) | 99.64% | 1396.68 | 10 MG
MK2-IN-5 acetate (Hsp25 kinase inhibitor acetate) is a Mk2 pseudosubstrate with a Ki of 8 μM. It targets the protein interaction domain in the MAPK pathway and inhibits HSP25 and HSP27 phosphorylation. In vitro, MK2-IN-5 acetate (5-10 μM, 2 hours) inhibits TGF-β1 induced connective tissue growth factor (CTGF) and collagen type I in primary human keloid fibroblasts. In vivo, a single intraperitoneal injection of 2 mg/kg of MK2-IN-5 acetate decreased HSP25 phosphorylation in a ventilator-associated lung injury model.
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