Sphingolipids
Medchemexpress LLC C16 PEG2000 Ceramide | 212116-78-4 | 99.37% | (C2H4O)nC39H73NO6 | 25 MG
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide that functions as a lipid carrier for delivery and induces autophagy. This compound is also utilized in cancer research, exhibiting cytotoxicity and promoting autophagy in N2a cells in vitro.
- Functions as a lipid carrier for delivery
- Induces autophagy
- Used in cancer research
- Exhibits cytotoxicity in N2a cells
- Promotes autophagy in N2a cells
- Increases LC3-II/LC3-I ratios in N2a cells
- Reduces WT-Tau and P301L-Tau proteins in N2a cells
Avanti Polar Lipids C18:0-d7 GD1b Ceramide (d18:1/18:0-d7), synthetic, 100ug
Gd1b plays various important roles in cell plasma membranes, but their current role is poorly understood. By deuterating GD1b, it should help researches understand their role by enabling of the easier study of structure, dynamics, and function of cell membranes.
Medchemexpress LLC Ceramide 3 | 34354-88-6 | >98.0% | C36H73NO4 | 1 MG
Ceramide 3 (also known as N-Stearoyl phytosphingosine or C18 Phytoceramide) is a bioactive sphingolipid naturally occurring in the stratum corneum of organisms like Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. It is structurally composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain.
- Regulates apoptosis, cell differentiation, and proliferation of smooth muscle cells
- Inhibits the mitochondrial respiratory chain
- Suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue
- Formulations are used as skin protectants in cosmetics
- Helps reduce water loss and prevent epidermal dehydration and irritation
Medchemexpress LLC C18:1-Ceramide-13C18 | 5966-28-9 | 97.0% | C1813C18H69NO3 | 1 MG
C18:1-Ceramide-13C18 is a 13C-labeled C18:1-Ceramide, which is a ceramide subspecies. It can be utilized in the study of type 2 diabetes and can serve as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Utilized in the study of type 2 diabetes
- Serves as a tracer or an internal standard for quantitative analysis
- Applicable for NMR, GC-MS, or LC-MS quantitative analysis
- Stable heavy isotopes incorporated for drug development quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Lyso-PAF C-16 | 52691-62-0 | 99.8% | C24H52NO6P | 1 MG
Lyso-PAF C-16 is a substrate for lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). It selectively acetylates with arachidonic acid and is intended for research use only. It has demonstrated cytotoxicity against various human cancer cell lines, including A549, HCT15, SK-MEL-3, SKOV3, and XF498.
- Substrate for lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD)
- Selectively acetylates with arachidonic acid
- Intended for research use only
- Exhibits cytotoxicity against human A549 cells (ED50 5.5 μg/mL)
- Exhibits cytotoxicity against human HCT15 cells (ED50 5.4 μg/mL)
- Exhibits cytotoxicity against human SK-MEL-3 cells (ED50 5.4 μg/mL)
- Exhibits cytotoxicity against human SKOV3 cells (ED50 4.9 μg/mL)
- Exhibits cytotoxicity against human XF498 cells (ED50 4.9 μg/mL)
Medchemexpress LLC C18:1-Ceramide | 5966-28-9 | 99.93% | C36H69NO3 | 100 MG
C18:1-Ceramide is a ceramide subspecies that can be used in the study of type 2 diabetes.
- High purity: 99.93%
- White to off-white solid appearance
- Shipping at room temperature in continental US
- Storage at 4°C, protected from light
![Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222171.png-250.jpg)
Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG
24:0 Lyso PC is a lysophospholipid supplied as a purified white to off-white solid for research use. It is used in studies of lipid metabolism and to formulate lipid nanoparticles for nucleic acid (mRNA) delivery, and is provided with documented chemical identity and stability data.
- Lysophospholipid useful for lipid nanoparticle formulation and mRNA delivery studies.
- High purity suitable for analytical and formulation research.
- White to off-white solid form, convenient for handling and storage.
- Stable under recommended storage conditions (powder at -20°C up to 3 years).
- Defined chemical identity and molecular weight for reproducible results.
Cayman Chemical C16 Ceramide d18 1 16 0
A sphingolipid; levels are increased by PPMP or MAPP in isolated human neutrophils and are correlated with an increase in apoptosis; accumulates in the lungs of patients with cystic fibrosis compared with the lungs of patients with pulmonary hypertension; plasma levels are increased in patients with acute coronary syndrome, and an increased plasma ratio of C16 to C24:0 ceramide is associated with major adverse cardiac events; levels are increased in tumor tissue from patients with breast cancer and is associated with metastatic cancer
TARGETMOL CHEMICALS INC C22 Ceramide d18 1 22 0 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. C22 Ceramide (d181/220) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes. Purity 97.97%
Medchemexpress LLC C6-NBD Sphinganine | 114301-97-2 | 99.0% | C30H51N5O6 | 1 MG
C6-NBD Sphinganine is a sphinganine analog utilized as a fluorescent dye for labeling fatty acids. This compound is intended for research use only and is not sold to patients. It has a molecular weight of 577.76 and appears as a yellow to orange solid. It exhibits an emission at 538 nm and an excitation at 460 nm.
- Functions as a fluorescent dye for labeling fatty acids, with specific excitation and emission wavelengths.
- Presents as a solid with a yellow to orange color.
- Soluble in DMSO at 20 mg/mL (34.62 mM); requires ultrasonic and warming for dissolution.
- Store at -20°C sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month.
- Strictly for research purposes; not for human use.
Abcam 3-Ketodihydrosphingosine hydrochloride, Ceramide biosynthesis intermediate, 10MG
MW 335.96 g/mol, Purity >98%. Necessary intermediate in ceramide (ab141745, ab141743) biosynthesis.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 9-Octadecenamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (9Z)- | 5966-28-9 | 99.9% | C36H69NO3 | 25 MG
C18:1-Ceramide is a ceramide subspecies that can be used in the study of type 2 diabetes. This product has a molecular weight of 563.94 and appears as a white to off-white solid.
- High purity, 99.9%
- Suitable for type 2 diabetes research
- Available in solid form
- Stable storage conditions
Medchemexpress LLC C16 ceramide-1-phosphate (d18:1/16:0) ammonium | 1246303-22-9 | 98.0% | 634.91 | C34H71N2O6P | 5 MG
C16 ceramide-1-phosphate (d18:1/16:0) (ammonium) is the ammonium salt of a bioactive sphingolipid, supplied as a purified research reagent for biochemical and cell biology studies of sphingolipid signaling and metabolism. It is provided as a characterized dry material for laboratory research use only and requires protected cold storage.
- High purity (98.0%).
- Molecular weight 634.91.
- Chemical formula C34H71N2O6P.
- Available in small pack sizes such as 5 MG.
- Storage: in solvent, -80°C (6 months) or -20°C (1 month); protect from light and store under nitrogen.
- Intended for biochemical assays and cell biology research; not for human use.
Medchemexpress LLC C24:1-ceramide (d18:1/24:1) | 54164-50-0 | MFCD02259277 | 99.9% | 648.10 g·mol⁻¹ | C42H81NO3 | 5 MG
C24:1-Ceramide (d18:1/24:1) is a long-chain sphingolipid commonly used in membrane biology, lipidomics, and formulation research. It functions as a reference standard and a structural lipid in liposome and lipid nanoparticle preparations for in vitro and analytical studies.
- High chemical purity reported by distributors (approximately 99.9%).
- Molecular formula C42H81NO3 and molecular weight ~648.10 g·mol-1.
- Solid form provided in small research pack sizes (mg scale) for analytical use.
- Suitable for membrane and lipidomics studies, and lipid nanoparticle formulation.
- Recommended storage at -20 °C to preserve stability.
- Supplied with CAS identifier 54164-50-0 for unambiguous reference.
Medchemexpress LLC N-hexanoylsphingosine | 124753-97-5 | 99.8% | 397.63 | C24H47NO3 | 10 MG
C6 ceramide is a short-chain, cell-permeable ceramide pathway activator used in cell-based research to induce apoptosis and modulate signaling pathways relevant to cancer progression and chemosensitivity.
- Induces apoptosis and cell cycle arrest in cancer cells.
- Enhances chemosensitivity in drug-resistant models.
- Soluble in DMSO at high concentrations for in vitro use.
- High purity for reproducible experimental results.
- Stable when stored as a powder at recommended temperatures.
- Available in multiple pack sizes for experimental flexibility.