Steroids and derivatives
Medchemexpress LLC Estradiol-d5 | 221093-45-4 | 99.1% | 1 MG
Estradiol-d5 is a deuterium-labeled form of Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during the drug development process.
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 25 MG
Estradiol 3-methyl ether is a synthetic estrogen. It can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibits cell proliferation. Estradiol 3-methyl ether has also been shown to decrease serum cholesterol levels and increase body weight loss, indicating feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks in V79 cells (EC50 of 9 μM)
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss in HFD murine models
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 50 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. The compound is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, demonstrating potent and long-acting STS inhibition.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Increased estrone sulfatase inhibitory activity with specific halogen moieties.
- Readily absorbed and transformed in the gut into its oxidative metabolite, EMATE.
- Both compounds demonstrate potent and long-acting STS inhibition.
Alkali Scientific Digitonin, Water Soluble, 500 Milligrams
Digitonin is a water-soluble compound used primarily in membrane permeabilization for research applications. Available in a 500mg format, Digitonin is widely used in cell biology to permeabilize cell membranes, allowing researchers to study intracellular components or deliver compounds directly into cells. It is particularly useful in protein extraction, cellular signaling studies, and in assays that require the breakdown of membrane integrity without damaging the cells entirely. This high-purity product facilitates effective permeabilization while maintaining cellular viability, making it essential for research on cellular processes, membrane proteins, and intracellular interactions.
Cayman Chemical 2-bromo 17-EstradIol 25mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 25 MG
Estradiol 3-sulfamate, also identified as BLE 00084, E2MATE, or ES-J 995, is characterized as a potent, long-acting, and orally active inhibitor of steroid sulfatase.
- Potent steroid sulfatase inhibitor
- Long-acting steroid sulfatase inhibitor
- Orally active steroid sulfatase inhibitor
- Inhibits estrone sulfatase with an IC50 of 251 nM
- Inhibits estrone sulfatase with a Ki of 133 nM
Selleck Chemical LLC Alpha-Estradiol
Alpha-Estradiol ( -Estradiol 17 alpha-Estradiol Alfatradiol Epiestradiol Epiestrol Alora 17 -E2) a natural non-feminizing stereoisomer a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 -E2) is a weak inhibitor of estrogen
Sigma Aldrich Fine Chemicals Biosciences Cyproterone acetate European Pharmacopoeia (EP) Reference Standard | 427-51-0 | MFCD00864671 |
Cyproterone acetate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 416.94 | 427-51-0 | MFCD00864671 |
Medchemexpress LLC Hydrocortisone acepo 50mg | 74050-20-7 | 460.56 g/mol | C26H36O7 | 50 MG
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) is a topical glucocorticoid supplied as a research/analytical standard for laboratory use. It is provided as a solid reference material (CAS 74050-20-7) for in vitro and analytical studies and is not intended for therapeutic use.
- Topical glucocorticoid for dermatoses research.
- Provided as a research/analytical standard for laboratory applications.
- CAS number 74050-20-7 and chemical formula C26H36O7.
- Molecular weight ~460.56 g/mol.
- Purity reported by vendors; consult the certificate of analysis before use.
- Available in multiple pack sizes, including 50 mg.
Medchemexpress LLC Chlorindanol | 145-94-8 | 98.0% | 50 MG
Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic and sanitizer. It exhibits low systemic toxicity, good skin, eyes, and genital mucosa tolerance, and is nonallergenic. It is rapidly lethal to various microorganisms in vitro, including vegetative bacteria, Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis, and spermatozoa.
- Topical antiseptic or sanitizer.
- Rapidly lethal to various microorganisms in vitro.
- Exhibits low systemic toxicity.
- Good skin, eyes, and genital mucosa tolerance.
- Nonallergenic.
Cayman Chemical HyodeoxycholIc ACD MaxSpec
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
Medchemexpress LLC Glycocholic acid (sodium) | 863-57-0 | 487.60 | 50 MG
Glycocholic acid (sodium) | 863-57-0 | 487.60 | 50 MG
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 500 MG
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. For research use only. Not sold to patients.
- Increases the cytotoxicity of epirubicin.
- Significantly increases intracellular accumulation of epirubicin in Caco-2 cells and absorption in rat small intestine.
- Intensifies epirubicin-induced apoptosis.
- Reduces mRNA expression of human intestinal MDR1, MRP1, and MRP2.
- Downregulates the MDR1 promoter region.
- Suppresses mRNA expression of Bcl-2 and induces mRNA expression of Bax.
- Significantly increases the Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3.
- Can control multidrug resistance (MDR) by modulating P-gp and MRPs, and regulating apoptosis-related pathways.