Purine nucleotides
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 100mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC Guanosine 5'-diphosphate-15N5 dilithium | 146-91-8 | 98.2% | 460.03 | 1 MG
Guanosine 5'-diphosphate-15N5 dilithium | 146-91-8 | 98.2% | 460.03 | 1 MG
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 559.32 | C15H23N5O14P2 | 50 MG
Adenosine 5'-diphosphoribose (ADP ribose) is a nucleotide metabolite supplied as a research reagent for biochemical and analytical studies. It is used to investigate NAD+ metabolism, TRPM2 channel activation, and ADP-ribosylation pathways. Intended for research use only.
- Nucleotide metabolite for biochemical and analytical assays.
- Molecular formula C15H23N5O14P2; molecular weight 559.32.
- Used in studies of NAD+ metabolism, TRPM2 activation, and ADP-ribosylation.
- Manufacturer datasheet lists pack sizes 1 mg, 5 mg, and 10 mg.
Apexbio Technology LLC 2'-O-Methyl-N6-Methyl-ATP 10ul (100 mM)
2p-O-Methyl-N6-Methyl-ATP is a chemically modified ATP analog bearing methyl substitutions at the N6 position of adenine and the 2 -hydroxyl group of the ribose sugar 2p-O-Methyl-N6-Methyl-ATP is designed to facilitate the study of RNA methylation processes and RNA protein interactions supporting the mechanistic exploration of RNA-modifying enzymes and epigenetic regulatory pathways Based on these properties 2p-O-Methyl-N6-Methyl-ATP holds research potential in investigations of ligand RNA interactions and drug discovery applications targeting RNA-related biological processes
Medchemexpress LLC Adenosine, 1-oxide | 146-92-9 | MFCD00037993 | 99.5% | 283.24 g/mol | C10H13N5O5 | 25 MG
Adenosine N1-oxide is a nucleoside derivative used in research as an orally active anti-inflammatory agent. It has been reported to promote osteogenic and adipocyte differentiation and is supplied as a purified research-grade solid with supporting documentation (COA, SDS).
- CAS 146-92-9
- Molecular formula C10H13N5O5
- Molecular weight 283.24 g/mol
- Purity 99.50%
- Available in small vial sizes for research use (e.g., 1-25 mg)
- Documentation: certificate of analysis and safety data sheet available
![Medchemexpress LLC 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(5-chloro-2-thienyl)sulfonyl]-1-phenyl- | 1023043-30-2 | 99.6% | 411.93 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439112-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(5-chloro-2-thienyl)sulfonyl]-1-phenyl- | 1023043-30-2 | 99.6% | 411.93 | 25 MG
ATP synthase inhibitor 1 is a potent inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening but does not affect ATP levels.
- Potent inhibitor of c subunit of the F1/FO-ATP synthase complex
- Inhibits mitochondrial permeability transition pore (mPTP) opening
- Does not affect ATP levels
Medchemexpress LLC Adenosine monophosphate (standard) | 61-19-8 | MFCD00655082 | 99.7% | C10H14N5O7P | 50 MG
Adenosine monophosphate (standard) is an analytical standard intended for research and analytical applications. It acts as an adenosine A1 receptor agonist, demonstrates significant antiviral activity against HSV-1 and HSV-2, and is a crucial cellular metabolite regulating energy homeostasis and signal transduction. This compound is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Acts as an adenosine A1 receptor agonist
- Demonstrates significant antiviral activity against HSV-1 and HSV-2
- Key cellular metabolite regulating energy homeostasis and signal transduction
- Used as an analytical standard in qualitative research
- Used as an analytical standard in quantitative research
- Used as an analytical standard in methodological research experiments including HPLC, GC, and MS
Medchemexpress LLC Guanosine, 6-O-methyl- | 7803-88-5 | 99.7% | 297.27 | 25 MG
6-O-Methyl Guanosine is identified as a modified nucleoside. Research indicates its capacity to inhibit the colony-forming ability in a malignant xeroderma pigmentosum cell line, suggesting potential applications in cell biology studies related to cell proliferation and specific genetic disorders. This modified nucleoside provides a tool for investigating cellular mechanisms and could contribute to understanding pathways involved in malignancy.
- Modified nucleoside.
- Inhibits colony-forming ability in a malignant xeroderma pigmentosum cell line.
Apexbio Technology LLC 2'-O-Methyl-2-Amino-ATP 100ul (100 mM)
2p-O-Methyl-2-Amino-ATP is a modified nucleoside triphosphate incorporating methylation at the ribose 2 -hydroxyl group and an amino substitution at the 2 position of the adenine base It is designed to alter nucleotide biochemical properties impacting RNA stability and structure upon enzymatic incorporation In in vitro transcription assays 2p-O-Methyl-2-Amino-ATP demonstrates an ability to increase RNA resistance to exonuclease-mediated degradation and induce altered RNA secondary structures Based on these properties 2p-O-Methyl-2-Amino-ATP holds research potential in studies of RNA folding dynamics stability assays RNA-protein interactions and analyses involving chemically modified RNA in biomedical research
Medchemexpress LLC Adenosine monophosphate | 61-19-8 | MFCD00655082 | 97% | C10H14N5O7P | 10 G
Adenosine monophosphate is identified as an adenosine A1 receptor agonist. This compound exhibits significant antiviral activity against both HSV-1 and HSV-2. It is also recognized as a key cellular metabolite, playing a vital role in the regulation of energy homeostasis and signal transduction within biological systems.
- Functions as an adenosine A1 receptor agonist.
- Demonstrates significant antiviral activity against HSV-1 and HSV-2.
- Acts as a key cellular metabolite.
- Involved in regulating energy homeostasis.
- Participates in signal transduction.
Apexbio Technology LLC Adenosine 58-61-7 1g
Adenosine (CAS 58-61-7) is a purine nucleoside consisting of adenine covalently linked to a ribose sugar via a -N9-glycosidic bond Endogenously adenosine modulates cellular signaling through activation of specific G protein-coupled adenosine receptors (A1 A2A A2B and A3) influencing diverse physiological processes such as neurotransmission vasodilation and immune responses In biomedical research adenosine is widely utilized to investigate purinergic signaling pathways cardiac function and the regulation of inflammatory and neuroprotective mechanisms as well as serving as a pharmacological tool in receptor binding and functional assays
Medchemexpress LLC Mtb ATP synthase-IN-1 | 2642394-38-3 | 98.6% | 323.30 | 100 MG
Mtb ATP synthase-IN-1 (compound 6ab) is identified as a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, demonstrating a MIC of 0.452-0.499 μg/mL against Mtb. This compound exhibits favorable metabolic stability, low cytotoxicity (with a Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. It is suitable for research applications focused on anti-mycobacterium studies.
- Potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor
- MIC of 0.452-0.499 μg/mL against Mtb
- Good metabolic stability
- Low cytotoxicity (Vero IC50 > 64 μg/mL)
- Acceptable oral bioavailability
- Intended for researching anti-mycobacterium
TARGETMOL CHEMICALS INC Research Chemical 500mg
Also available in and bulk. Please contact Fisher for quotes. Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), Cytidine-5'-triphosphate disodium reacts with phosphocholine, via CTP,phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate. purity: 97%