Drug Standards
FUJIFILM BIOSCIENCES INC Valproic Acid | 99-66-1 | MFCD00002672 | 5g
Valproic Acid | Purity: % | Mol Wt: 144.21 | 99-66-1 | MFCD00002672 | 5g
Selleck Chemical LLC Flumazenil 100mg 78755-81-4 RO 15-1788
Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Colchicine | 64-86-8 | 99.9% | 399.44 | 100 MG
Colchicine is an orally active alkaloid that acts as a potent tubulin inhibitor and a microtubule disrupting agent. It is intended for research and analytical applications.
- Inhibits microtubule polymerization with an IC50 of 3 nM.
- Acts as a competitive antagonist of the α3 glycine receptors (GlyRs).
- Prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome.
- Possesses extensive anti-inflammatory, immunosuppressive, and strong anti-fibrosis effects.
- Has potential for gouty arthritis research.
- Commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Can be used to induce Alzheimer's disease models.
Medchemexpress LLC Lidocaine | 137-58-6 | 99.96% | 234.34 | 5 G
Lidocaine inhibits sodium channels involving complex voltage and dependence. It decreases growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and further inactivating MEK/ERK and NF-κB signaling pathways. As an amide derivative, it has potential for ventricular arrhythmia research.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Up-regulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Causes reversible tail nerve block in rats
- Inhibits human TREK-1 in HEK293 cells
- Inhibits cell viability in human gastric cancer cell lines
- Increases apoptotic cell rate
- Down-regulates Cyclin D1 and up-regulates p21 expression
Medchemexpress LLC Dodecyl gallate | 1166-52-5 | MFCD00002195 | 99.8% | 338.44 g/mol | C19H30O5 | 100MG
Dodecyl gallate (CAS 1166-52-5) is the analytical reference standard of lauryl gallate supplied for research and analytical use. The material is provided with high purity and characterized for formula and molecular weight, making it suitable for antioxidant studies and analytical assays.
- Analytical reference standard for dodecyl (lauryl) gallate.
- High purity, 99.8%.
- Chemical formula C19H30O5.
- Molecular weight 338.44 g/mol.
- Available in small pack sizes, including 100 mg.
- Intended for research and analytical applications.
Selleck Chemical LLC Triamcinolone Acetonide S1628-1g
Triamcinolone acetonide is a synthetic glucocorticoid used in the symptomatic treatment of inflammation
Medchemexpress LLC Ibiglustat (succinate) | 1629063-80-4 | 99.7% | 507.57 | 25 MG
Ibiglustat succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
- Orally active
- Brain-penetrant glucosylceramide synthase (GCS) inhibitor
- Can prevent additional GL-3 accumulation in Fabry disease cells
Selleck Chemical LLC Econazole nitrate 50mg 24169-02-6 NSC 243115
Econazole Nitrate (NSC 243115) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Binimetinib | 606143-89-9 | C17H15BrF2N4O3 | 5 MG
Binimetinib is an oral and selective MEK1/2 inhibitor that inhibits MEK with an IC50 of 12 nM. This laboratory chemical is primarily used for the manufacture of substances.
- Oral and selective MEK1/2 inhibitor
- Inhibits MEK with an IC50 of 12 nM
- Suitable for use as a laboratory chemical
- Utilized in the manufacture of substances
Selleck Chemical LLC Decitabine 10mM/1mL 2353-33-5 Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR
Decitabine (Deoxycytidine, Dacogen, 5-aza-2-deoxycytidine, 5-AZA-dC, 5-aza-CdR) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Plerixafor (AMD3100), 50mg. Cas: 110078-46-1 MFCD: MFCD05662218. CXCR4 chemokine receptor antagonist
Plerixafor (AMD3100) is a small-molecule antagonist of CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. CXCR4 and SDF-1 are key factors in regulating cancer cell invasion and metastasis, and plerixafor can prevent the binding of SDF-1 to CXCR4 for inhibiting cancer metastasis. Plerixafor interfered with CXCL12/CXCR4 mediated retention of hematopoietic stem cells in the bone marrow, and resulted in their mobilization to the blood. Plerixafor amplified the release of circulating neutrophils from the oriented area in the lung, while simultaneously preventing neutrophil returned to the bone marrow. Three adults with WHIM syndrome were subcutaneously injected 0.01 to 0.02 mg/kg plerixafor twice daily for 6 months, circulating leukocytes were constantly increased, and associated with fewer infections. Other sizes are available. Please inqury us for quote.
Cayman Chemical RosuvastatIncalcIum salt 100mg
An HMG-CoA reductase inhibitor (IC50 = 5 nM); inhibits cholesterol synthesis in isolated rat hepatocytes (IC50 = 0.16 nM); reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet at 10 mg/kg; decreases the area of aortic atherosclerotic lesions in the same model
Medchemexpress LLC Itacitinib (INCB039110) | 1334298-90-6 | 99.97% | 553.51 | 1 MG
Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1, exhibiting an IC50 of 2 nM for human JAK1. It demonstrates over 20-fold selectivity for JAK1 compared to JAK2, and over 100-fold selectivity over JAK3 and TYK2. Itacitinib is currently utilized in research concerning myelofibrosis.
- Orally active and selective JAK1 inhibitor.
- IC50 of 2 nM for human JAK1.
- High selectivity: >20-fold over JAK2, and >100-fold over JAK3 and TYK2.
- Used in myelofibrosis research.
Selleck Chemical LLC Cisplatin S1166-1g
Cisplatin is an inorganic platinum complex which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells Cisplatin activates ferroptosis and induces autophagy Solutions are unstable and should be fresh-prepared DMSO is not recommended to dissolve platinum-based drugs which can easily lead to drug inactivation