Drug Standards
Medchemexpress LLC Enoxaparin sodium | 679809-58-6 | 10 MG
Enoxaparin (PK 10169) is a low-molecular-weight heparin (LMWH) derivative that acts as an anticoagulant by inhibiting factor Xa and thrombin IIa through antithrombin III. It also possesses antioxidant and anti-inflammatory properties, protecting the rat hippocampus against traumatic brain injury (TBI). Enoxaparin is used in research for conditions such as deep vein thrombosis (DVT), pulmonary embolism, TBI, and COVID-19.
- Low-molecular-weight heparin (LMWH) derivative.
- Exerts anticoagulant activity.
- Inhibits factor Xa and thrombin IIa.
- Protects against TBI via antioxidant and anti-inflammatory properties.
- Potential research applications include deep vein thrombosis (DVT), pulmonary embolism, TBI, and COVID-19.
Medchemexpress LLC Talazoparib tosylate | 1373431-65-2 | 507274 | 99.9% | 552.55 | 50 MG
Talazoparib tosylate (BMN 673ts) is a novel, potent, and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. It is for research use only and has not been fully validated for medical applications.
- Potent PARP1/2 inhibitor
- Orally available
- Suitable for research applications
Medchemexpress LLC Gemcitabine monophosphate | 116371-67-6 | 99.98% | 343.18 | 25 MG
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is an active intermediate of Gemcitabine. It exhibits a synergistic anti-cancer effect and can be delivered through formulation into nanoparticles. It is intended for research use only. The product appears as a solid, white to off-white in color.
- Functions as an active intermediate.
- Demonstrates a synergistic anti-cancer effect.
- Can be effectively delivered by formulating it into nanoparticles.
- An in vivo study showed that combined treatment exhibited anti-small cell lung cancer activity and induced apoptosis.
- Soluble in DMSO (200 mg/mL) and H2O (100 mg/mL).
Medchemexpress LLC Folic acid | 59-30-3 | 99.02% | 441.40 | 25 MG
Folic acid, also known as Vitamin B9, is an orally active essential nutrient from the B complex group of vitamins. It is utilized in research for its antidepressant-like effects and its role in reducing the risk of neonatal neural tube defects. Additionally, it is studied for its involvement in megaloblastic and macrocytic anemias, prevention of chromosome breakage, and DNA hypomethylation. This compound can also be used to induce acute kidney injury models.
- Essential nutrient from the B complex group of vitamins
- Demonstrates antidepressant-like effects
- Helps reduce the risk of neonatal neural tube defects (as its sodium form)
- Utilized in research concerning megaloblastic and macrocytic anemias
- Plays a critical role in preventing chromosome breakage
- Involved in DNA hypomethylation research
- Can be used to induce acute kidney injury models
Medchemexpress LLC Itacitinib adipate | 1334302-63-4 | 99.2% | 699.66 | 5 MG
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor that has been tested for efficacy and safety in a phase II trial in myelofibrosis. It is suitable for research use only.
- Orally bioavailable
- Selective JAK1 inhibitor
- Tested in phase II trial for myelofibrosis
- Suitable for research use
Medchemexpress LLC Folic acid-13C5 | 1207282-75-4 | 95.0% | 446.36 | 500 UG
Folic acid-13C5 is the 13C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; it is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis. This product is for research use only and not sold to patients.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC ARQ 621 | 1095253-39-6 | 98.1% | 552.43 | 100 MG
ARQ 621 is an allosteric, potent, and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. It exhibits anti-tumor activity and acts as a kinesin inhibitor. Additionally, ARQ 621 is a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Allosteric, potent, and selective Eg5 inhibitor
- Exhibits anti-tumor activity
- Acts as a kinesin inhibitor
- Click chemistry reagent with an alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Methylprednisolone (Standard) | 83-43-2 | 99.8% | 25 MG
Methylprednisolone is a synthetic corticosteroid possessing anti-inflammatory and immunomodulating properties. It has been shown to improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Methylprednisolone is commonly utilized for anti-inflammatory purposes, including in the study of bronchial inflammation or acute bronchitis associated with arthritis and various respiratory diseases. It can also enhance neurological recovery in cases of acute spinal cord injury.
- Synthetic corticosteroid.
- Exhibits anti-inflammatory properties.
- Has immunomodulating properties.
- Can improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
- Used in the study of bronchial inflammation or acute bronchitis.
- May aid in neurological recovery for acute spinal cord injury.
Medchemexpress LLC Hydrochlorothiazide (Standard) | 58-93-5 | 99.55% | 25 MG
Hydrochlorothiazide (Standard) is an analytical standard of Hydrochlorothiazide, intended for research and analytical applications. It is an orally active diuretic agent of the thiazide class, known for inhibiting the transforming TGF-β/Smad signaling pathway and exhibiting direct vascular relaxant effects by opening the calcium-activated potassium (KCA) channel. This compound improves cardiac function, reduces fibrosis, and possesses an antihypertensive effect. With a molecular weight of 297.74 and a formula of C₇H₈ClN₃O₄S₂, it appears as a white to off-white solid.
- Used as a reference standard for assays
- Commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
- Improves cardiac function
- Reduces fibrosis
- Antihypertensive effect
Medchemexpress LLC Lidocaine (Standard) | 137-58-6 | 99.9% | 25 MG
Lidocaine (Standard) is the analytical standard of Lidocaine, intended for research and analytical applications. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. It decreases growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and further inactivating MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.
- The compound is the grade of analytical standard, which is the reference standard supplied assay.
- It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Latanoprost | 130209-82-4 | MFCD00864319 | >98% | 25 MG
Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor. It is primarily used in glaucoma research to effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through the uvea. It can effectively pass through the cornea and is hydrolyzed by esterase to latanoprost acid.
- Prostaglandin F2α analogue
- Agonist for the FP prostanoid receptor
- Lowers intraocular pressure (IOP)
- Inhibits VEGF-induced proliferation and migration in human umbilical vein endothelial cells (HUVECs)
- Suppresses retinal neovascularization in vitro
- Increases cell viability in HUVECs and human retinal microvascular endothelial cells (HRMECs)
- Decreases levels of Akt, Erk1/2, NF-κB, and VEGF expression
- Reduces blood flow in the optic nerve head, iris, and choroid
- Inhibits the development of choroidal neovascularization in mice
Medchemexpress LLC Norfloxacin | 70458-96-7 | 99.8% | 50 MG
Norfloxacin (Standard) is the analytical standard of Norfloxacin, intended for research and analytical applications. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Analytical standard for research and analytical applications
- Broad-spectrum antibiotic
- Active against Gram-positive and Gram-negative bacteria
- Inhibits DNA gyrase
- Used in HPLC, GC, and MS experiments
- White to off-white solid appearance
Medchemexpress LLC Norfloxacin | 70458-96-7 | 99.8% | 100 MG
Norfloxacin (Standard) is an analytical standard intended for research and analytical applications. This broad-spectrum antibiotic is active against both Gram-positive and Gram-negative bacteria, functioning by inhibiting DNA gyrase. It is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Active against Gram-positive and Gram-negative bacteria
- Inhibits DNA gyrase
- Suitable for HPLC, GC, and MS research experiments
Medchemexpress LLC Norfloxacin-d5 | 1015856-57-1 | 99.9% | 1 MG
Norfloxacin-d5 is a deuterium labeled Norfloxacin, functioning as a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria by inhibiting DNA gyrase. Deuterium substitution can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ketorolac (tromethamine salt) | 74103-07-4 | MFCD00887595 | 99.5% | 1 G
Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent that acts as a nonselective COX inhibitor. With IC50s of 20 nM for COX-1 and 120 nM for COX-2, this compound is intended for laboratory chemical use and substance manufacturing, and is for research use only.
- Non-steroidal anti-inflammatory agent
- Nonselective COX inhibitor
- Solid appearance
- Purity of 99.5%
- IC50 of 20 nM for COX-1
- IC50 of 120 nM for COX-2