Drug Standards
Apexbio Technology LLC Cabozantinib (XL184, BMS-907351) 849217-68-1 10mM (in 1mL DMSO)
Cabozantinib (XL184 BMS-907351 CAS 849217-68-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) notably VEGFR2 MET and RET with reported IC50 values of 0 035 nmol/L 1 3 nmol/L and 5 2 nmol/L respectively Acting by blocking downstream phosphorylation events cabozantinib disrupts RTK-mediated cell signaling pathways fundamental to cellular proliferation and differentiation In vitro studies utilizing RET-mutant TT cells showed dose-dependent inhibition of RET autophosphorylation (IC50 85 nmol/L) and reduced cellular proliferation In vivo experiments using TT-cell xenograft mouse models demonstrated tumor growth suppression and decreased serum calcitonin levels Cabozantinib serves as a valuable tool in oncology and RTK-related signaling research
Selleck Chemical LLC Cefditoren Pivoxil 10mg 117467-28-4 ME-1207
Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | 42017-89-0 | MFCD00792461 | 25MG
Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 318.75 | 42017-89-0 | MFCD00792461 | 25MG
Apexbio Technology LLC Glycopyrrolate 596-51-0 25mg
Glycopyrrolate (CAS 596-51-0) is a small molecule that acts as a competitive antagonist of muscarinic acetylcholine receptors By blocking muscarinic receptor-mediated cholinergic signaling it inhibits smooth muscle contractions and reduces secretory gland activity This pharmacological profile makes glycopyrrolate a valuable tool in studies investigating muscarinic receptor function neurotransmission and cholinergic pathways It is frequently used in research focused on gastrointestinal motility airway regulation and autonomic nervous system modulation
Medchemexpress LLC (R)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid | 1270093-99-6 | ≥97.0% | 243.28 | 1 G
Lifitegrast impurity 6 is identified as an impurity of Lifitegrast and serves as a drug intermediate. It is supplied as a solid, white to off-white in appearance.
- Impurity of Lifitegrast
- Functions as a drug intermediate
- Solid, white to off-white appearance
- Recommended storage at room temperature for 3 years, or in solvent at -80°C for 2 years or -20°C for 1 year
- For research use only, not fully validated for medical applications
Apexbio Technology LLC Ketoconazole 65277-42-1 500mg
Ketoconazole (65277-42-1) is a small-molecule inhibitor targeting cytochrome P450-dependent enzymes including cyclosporine oxidase and testosterone 6 -hydroxylase It is designed to inhibit these catalytic activities thereby modulating the oxidative metabolism of clinically relevant substrates Ketoconazole exerts its biological activity primarily through inhibition of cytochrome P450-mediated pathways In in vitro studies ketoconazole demonstrates inhibitory activity with an IC50 of approximately 0 19 mM for cyclosporine oxidase and about 0 22 mM for testosterone 6 -hydroxylase Based on these pharmacological properties ketoconazole holds research potential in studies of drug-drug interactions hepatic enzyme induction and metabolic profiling assays
Sigma Aldrich Fine Chemicals Biosciences Allyl cyclohexane valerate United States Pharmacopeia (USP) Reference Standard | 7493-68-7 | 3X0.5ML
Allyl cyclohexane valerate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 224.34 | 7493-68-7 | 3X0.5ML
![Medchemexpress LLC 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)- | 343-55-5 | 98.0% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000413355-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)- | 343-55-5 | 98.0% | 5 MG
Dicloxacillin sodium is a β-lactam antibiotic belonging to the penicillin family. It is effective against Gram-positive bacteria, including β-lactamase-producing organisms such as *Staphylococcus aureus*.
- β-lactam antibiotic.
- Active against Gram-positive bacteria.
- Effective against β-lactamase-producing organisms like *Staphylococcus aureus*.
Medchemexpress LLC Citalopram hydrobromide | 59729-32-7 | 99.87% | 5 MG
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that exhibits blood-brain barrier permeability. It inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM and in rabbit blood platelets with an IC50 of 14 nM, demonstrating an antidepressant effect.
- Selective serotonin reuptake inhibitor
- Permeates the blood-brain barrier
- Inhibits 5-HT uptake into synaptosomes
- Inhibits 5-HT uptake in rabbit blood platelets
- Exhibits antidepressant effects
- For research use only
Medchemexpress LLC Neratinib | 698387-09-6 | MFCD09752958 | 99.9% | 557.0 g/mol | 1 ML
Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Less active in cell lines not expressing HER-2 or EGFR.
- Arrests cell cycle at G1-S phase.
- Causes inhibition of MAPK and Akt phosphorylation, down-regulation of cyclin D1 levels, and induction of p27.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR in vivo.
- Reduces tumor growth in a dose-dependent manner in xenografts.
- Inhibits phosphorylation of HER-2 in xenografts.
Selleck Chemical LLC Oxfendazole S1830-50mg
Oxfendazole (RS-8858 Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 200 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits little to no activity at other steroid receptors and also possesses anti-viral activity. Its applications span immunology, anti-infection, and metabolic research.
- Potent topical anti-inflammatory corticosteroid
- Selective glucocorticoid receptor agonist (KD of 0.5 nM)
- Exhibits minimal activity at other steroid receptors
- Possesses anti-viral activity
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM
- Targets glucocorticoid receptor, endogenous metabolite, enterovirus, and ADC payload
- Relevant to immunology/inflammation, vitamin D related/nuclear receptor, metabolic enzyme/protease, anti-infection, and antibody-drug conjugate/ADC related pathways
Medchemexpress LLC Triamcinolone (Standard) | 124-94-7 | MFCD00010477 | 98.02% | 100 MG
Triamcinolone (Standard) is an analytical reference standard used for research and analytical applications. This product is suitable for qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Intended for research and analytical applications
- Used as an analytical standard
- Suitable for qualitative research experiments
- Suitable for quantitative research experiments
- Suitable for methodological research experiments
- Compatible with HPLC
- Compatible with GC
- Compatible with MS
Medchemexpress LLC Ciclopirox | 29342-05-0 | 98.3% | 1 ML
Ciclopirox is a synthetic, orally active antifungal agent used in research for superficial mycoses. It demonstrates broad-spectrum activity against dermatophytes, yeasts, molds, and various pathogenic bacteria, and also exhibits anticancer and anti-inflammatory effects.
- Synthetic, orally active antifungal agent
- Used for superficial mycoses research
- Exhibits broad-spectrum activity against dermatophytes, yeasts, molds, and pathogenic bacteria
- Demonstrates anticancer and anti-inflammatory effects
- Available as a 10 mM x 1 mL solution in DMSO
- Shipped at room temperature
- Powder storage: -20°C for 3 years or 4°C for 2 years
- In-solvent storage: -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC Bromfenac sodium hydrate | 120638-55-3 | 99.9% | 200 MG
Bromfenac sodium hydrate is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. It can be used in ocular inflammation research.
- Potent and orally active inhibitor of COX.
- Can be used in ocular inflammation research.
- Available in solid and solution forms.