Drug Standards
Medchemexpress LLC Bupropion morpholinol | 357399-43-0 | 99.7% | 10 MG
Bupropion morpholinol, also known as Hydroxy Bupropion, is a major metabolite of Bupropion. It functions by inhibiting Dopamine and Norepinephrine transporters, as well as the α4β2 nicotinic receptor in vitro. This compound plays a role in antidepressant and smoking cessation activities. It is produced from Bupropion in vivo by the genetically polymorphic enzyme CYP2B6. It inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM. This product is intended for research use only and is not sold to patients.
- Major metabolite of bupropion
- Inhibits dopamine and norepinephrine transporters
- Inhibits the α4β2 nicotinic receptor in vitro
- Contributes to antidepressant and smoking cessation activities
- Produced from bupropion by the genetically polymorphic enzyme CYP2B6 in vivo
- Inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM
- Intended for research use only
Apexbio Technology LLC Ivermectin 70288-86-7 10mM (in 1mL DMSO)
Ivermectin is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors ( 7 nAChR) and purinergic receptors (P2X4) Additionally ivermectin influences chloride ion channels regulated by glutamate and GABA and also enhances glycine receptor-mediated currents at low concentrations It is commonly employed in neuropharmacological research examining receptor function ion channel activity and neurotransmitter signaling pathways As an anthelmintic ivermectin is widely used in parasitology research for its inhibition of parasite neuromuscular transmission Reported IC50 values vary among receptor types generally ranging from nanomolar to micromolar levels depending on assay conditions and biological context
Apexbio Technology LLC Carmustine 154-93-8 10mg
Carmustine (CAS 154-93-8) is a -chloro-nitrosourea nitrogen mustard compound utilized as an antitumor chemotherapeutic agent It exerts its effects primarily through alkylation of DNA and proteins leading to cross-linking and inhibition of cellular replication and function In research studies carmustine has been shown to attenuate N-acetyltransferase activities for substrates such as 2-aminofluorene and p-aminobenzoic acid in rat glial tumor models and to decrease the formation of DNA-2-aminofluorene adducts In vivo carmustine administration in rats impacts hepatic parameters including increased liver-to-weight ratio reduced bile flow and altered glutathione redox status accompanied by histological changes Carmustine is widely employed in oncology research to investigate mechanisms of cytotoxicity and drug-induced liver injury
![Medchemexpress LLC Ethyl 3-(1,2-dimethyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate | 1456889-80-7 | MFCD28400019 | 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000267599.png-250.jpg)
Medchemexpress LLC Ethyl 3-(1,2-dimethyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate | 1456889-80-7 | MFCD28400019 | 5mg
Dabigatran impurity 45 is an impurity of Dabigatran (HY-10163)
Medchemexpress LLC Ganoderic acid T-Q | 112430-66-7 | 5 MG
Ganoderic acid T-Q is a natural product found in Ganoderma lucidum that stimulates tubulin polymerization. This product is a white to off-white solid with high purity, intended for research applications only.
- Stimulates tubulin polymerization
- Natural product from Ganoderma lucidum
- White to off-white solid appearance
- Purity of 99.41%
- Intended for research use only
Selleck Chemical LLC Ganciclovir S1878-1g
Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5 2 M in a cell-free assay
Selleck Chemical LLC Gibberellic acid S4766-25mg
Gibberellic acid (Gibberellin Gibberellin A3 GA3 GA) a plant hormone stimulating plant growth and development is a tetracyclic di-terpenoid compound
Selleck Chemical LLC Cabozantinib malate S4001-200mg
Cabozantinib malate (XL184) is the malate of Cabozantinib a potent VEGFR2 inhibitor with IC50 of 0 035 nM and also inhibits c-Met Ret (c-Ret) Kit (c-Kit) Flt-1/3/4 Tie2 and AXL with IC50 of 1 3 nM 4 nM 4 6 nM 12 nM/11 3 nM/6 nM 14 3 nM and 7 nM in cell-free assays respectively Cabozantinib malate (XL184) induces apoptosis
Medchemexpress LLC Afatinib impurity 9 | 2170273-17-1 | 5mg
Afatinib impurity 9 is an impurity of Afatinib (HY-10261)
Apexbio Technology LLC Fluconazole hydrate 155347-36-7 100mg
Fluconazole hydrate (CAS 155347-36-7) is a small-molecule inhibitor targeting the fungal enzyme lanosterol 14 -demethylase It is designed to inhibit ergosterol biosynthesis thereby disrupting fungal cell membrane integrity and arresting fungal growth Fluconazole hydrate exerts its biological activity primarily through inhibition of lanosterol 14 -demethylase In in vitro studies fluconazole hydrate demonstrates inhibitory activity with documented IC50 values typically ranging from 0 1 to 10 g/mL depending on fungal strain and experimental conditions Based on these pharmacological properties fluconazole hydrate holds research potential in antifungal pharmacology assays fungal infection model studies and evaluation of combinational antifungal therapies
Medchemexpress LLC Clarithromycin (Standard) | 81103-11-9 | 99.9% | 747.95 | 100 MG
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. It has a broad spectrum of antimicrobial activity and inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation. Clarithromycin also significantly inhibits the HERG potassium current and affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K.
- The compound is an analytical standard, which is the reference standard supplied assay.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Appearance: Solid.
- Color: White to off-white.
TARGETMOL CHEMICALS INC Ciclopirox olamine 500MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Purity 98.97%
TARGETMOL CHEMICALS INC Zileuton 200MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Purity 99.56%
Cayman Chemical Mifepristone Neurochemicals
An antagonist of glucocorticoid, progesterone, and androgen receptors (Kis = 0.1, 0.64, and 0.65 nM, respectively); selective for these receptors over MR, ERα, and ERβ (Kis = 640, >200, and >750 nM, respectively); inhibits R5020-stimulated alkaline phosphatase activity as well as reporter transcription stimulated by either dexamethasone or R5020 in cell-based assays (IC50s = 7, 5.9, and 1.3 nM, respectively); inhibits R1881-stimulated reporter transcription in a concentration-dependent manner; inhibits growth of 4-OHT-resistant MCF-7 breast cancer cells in vitro at 10 µM; inhibits tumor growth in an SKOV3 ovarian cancer nude mouse xenograft model at 0.5 or 1 mg per day