Drug Standards
Apexbio Technology LLC Bromhexine HCl 611-75-6 10mM (in 1mL DMSO)
Bromhexine Hydrochloride is an expectorant compound utilized frequently in respiratory research to examine mucolytic mechanisms It functions primarily by disrupting acidic polysaccharide fibers within bronchial mucus reducing mucus viscosity and facilitating mucociliary clearance The compound is routinely employed in in vitro studies involving respiratory epithelial cells and ex vivo respiratory tract tissues to investigate its pharmacological influence on mucus production and secretion Reported IC50 values for Bromhexine Hydrochloride in mucolytic assays typically range between 30-50 M under standard experimental conditions Its applications extend to the study of respiratory disorders associated with abnormal mucus secretion enabling researchers to better characterize molecular pathways involved in mucus regulation and investigate potential therapeutic targets
Medchemexpress LLC Citalopram (hydrobromide) | 59729-32-7 | 1 ML
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) with blood-brain barrier permeability. It inhibits 5-HT uptake into synaptosomes and rabbit blood platelets, demonstrating an antidepressant effect. It also exhibits concentration-dependent cytotoxicity on various neuroblastoma cell lines and human primary Schwann cells in vitro.
- Selective serotonin reuptake inhibitor (SSRI)
- Blood-brain barrier permeability
- Inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM
- Inhibits 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM
- Exhibits concentration-dependent cytotoxicity on various neuroblastoma cell lines and human primary Schwann cells in vitro
Medchemexpress LLC Meclizine dihydrochloride | 1104-22-9 | 99.95% | 1 ML
Meclizine dihydrochloride is an antihistamine that reversibly inhibits the interaction of histamine at the H1 receptors. As a member of the piperazine class of H1 antagonists, it serves as an effective anti-motion sickness agent. This compound can cross the blood-brain barrier, making it suitable for research into polyQ toxicity disorders such as Huntington's disease. It acts as an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. When stored as a solution, it should be kept at -80°C for up to 6 months or -20°C for up to 1 month, under sealed conditions and away from moisture.
- Reversibly inhibits histamine at H1 receptors
- Effective anti-motion sickness agent
- Crosses the blood-brain barrier
- Used for research of polyQ toxicity disorders
- Agonist for mouse CAR and inverse agonist for human CAR
Medchemexpress LLC Triamcinolone | 124-94-7 | 99.8% | 5 G
Triamcinolone is a long-acting corticosteroid that exhibits anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory, and neuroprotective effects by binding to glucocorticoid receptors. It is used to alleviate several dermatitis, immune diseases, and ocular diseases.
- Long-acting corticosteroid.
- Exhibits anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory, and neuroprotective effects.
- Binds to glucocorticoid receptors.
- Used to alleviate dermatitis, immune diseases, and ocular diseases.
- Demonstrates dose-dependent inhibition of bovine retinal endothelial cell proliferation.
- Lowers neovascular cell count in retinopathy of prematurity animal models.
- Investigated in numerous clinical trials.
Medchemexpress LLC S-diclofenac | 912758-00-0 | 99.2% | 504.47 g/mol | C23H15Cl2NO2S3 | 10 MG
S-diclofenac is a hybrid molecule that combines an H2S donor with the nonsteroidal anti-inflammatory scaffold of diclofenac. It shows multifaceted biological activity including activation of the p53 signaling pathway, inhibition of JNK, antioxidant effects, and anti-inflammatory activity, and has been used in both in vitro and in vivo research models to study inflammation, oxidative stress, and cardiac injury.
- Activates the p53 signaling pathway and upregulates downstream effectors.
- Inhibits JNK activation, modulating stress-related signaling.
- Exhibits antioxidant and anti-inflammatory properties.
- Demonstrates efficacy in animal models of edema and myocardial injury.
- Provided at high listed purity to support research reproducibility.
- Available as small solid packages and as a solution in DMSO for convenience.
- Solid appearance described as reddish brown to red.
Medchemexpress LLC Voriconazole (racemic) | 188416-29-7 | MFCD00905717 | 99.1% | 349.31 g/mol | C16H14F3N5O | 10 MG
(±)-Voriconazole (racemic) is a research-grade antifungal triazole supplied as a high-purity solid for laboratory use. The compound is intended for in vitro and preclinical studies exploring fungal inhibition and ergosterol biosynthesis, and is provided in small, accurately measured quantities for analytical assays and mechanistic research.
- High purity suitable for research applications.
- Racemic mixture for comparative stereochemistry studies.
- Solid form convenient for weighing and formulation.
- Suitable for in vitro antifungal assays and mechanism studies.
- Measured quantities for analytical and preclinical workflows.
Medchemexpress LLC (±)11(12)-EET-d11 | 2699607-19-5 | 98.0% | 10 UG
(±)11(12)-EET-d11 is a deuterium labeled form of (±)11(12)-EET, functioning as an NLRP3 inflammasome inhibitor. It is used in research for anti-inflammatory, angiogenic, and cardioprotective effects. This compound can serve as a tracer and an internal standard for quantitative analysis by techniques like NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Inhibits NLRP3 inflammasome
- Used in anti-inflammatory, angiogenic, and cardioprotective research
- Functions as a tracer
- Serves as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
Cayman Chemical MogrosIde IIIE 1mg
A cucurbitane glycoside with anti-inflammatory activity; inhibits LPS-induced secretion of IL-1β, IL-6, and TNF-α from, as well as LPS-induced increases in TLR4 levels in, RAW 264.7 macrophages at 50 µM; reduces increases in BALF levels of IL-1β, IL-6, and TNF-α, and increases in lung tissue Mpo activity in a mouse model of LPS-induced acute lung injury at 20 mg/kg; decreases lung fibrosis and inflammation, as well as increases animal survival and reduced lung levels of MMP-9, in a mouse model of bleomycin-induced pulmonary fibrosis at 20 mg/kg per day
Apexbio Technology LLC Bumetanide 10mM (in 1mL DMSO)
A1855 is a small molecule compound developed for biomedical research applications As a research reagent it is primarily utilized to investigate biological pathways at the molecular level and elucidate potential therapeutic mechanisms Its precise molecular target and mechanism of action have not yet been publicly characterized Researchers employ A1855 as a chemical probe in various experimental systems to explore cellular signaling pathways and identify modulators of biological processes aiding in drug discovery and basic biomedical research
Apexbio Technology LLC Losartan Potassium (DuP 753) 124750-99-8 10mM (in 1mL DMSO)
Losartan Potassium (DuP 753 CAS 124750-99-8) is a small molecule antagonist selective toward angiotensin AT receptors By competitively blocking AT receptors it inhibits angiotensin II-mediated vasoconstriction demonstrated by antagonism of contractile responses in isolated rabbit aortic and jugular vein tissues (pA 8 27) As an orally bioavailable agent losartan potassium is frequently utilized in cardiovascular research notably in studies investigating hypertension and associated mechanisms of angiotensin II signaling
Sigma Aldrich Fine Chemicals Biosciences Sodium cholate hydrate suitable for cell culture, BioReagent | 206986-87-0 | MFCD00150749 | 100G
Sodium cholate hydrate suitable for cell culture, BioReagent | Purity: >=99.0% (HPLC) | 206986-87-0 | MFCD00150749 | 100G
Medchemexpress LLC Tavarborol impurity 16 | 1839665-96-1 | MFCD32689443 | 247.06 | 5 G
Tavarborol impurity 16 is an impurity of Tavaborol. It is used as a drug intermediate.
- Impurity of Tavaborol
- Suitable for drug intermediate research
Medchemexpress LLC Mifepristone (Standard) | 84371-65-3 | 99.4% | 429.59 | 50 MG
Mifepristone (Standard) is an analytical standard intended for research and analytical applications. It acts as a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist. This standard is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist
- Suitable for HPLC, GC, and MS experiments
Medchemexpress LLC Raloxifene (hydrochloride) | 82640-04-8 | 99.8% | 510.04 | 100 MG
Raloxifene hydrochloride is a second generation selective and orally active estrogen receptor modulator. It produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue. It is for research use only and not sold to patients.
- Second generation selective and orally active estrogen receptor modulator
- Estrogen-agonistic effects on bone and lipid metabolism
- Estrogen-antagonistic effects on uterine endometrium and breast tissue
- For research use only