Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Estradiol | 50-28-2 | MFCD00003693 | 1 g
Estradiol | Mol Wt: 272.38 | 50-28-2 | MFCD00003693 | 1 g
AdipoGen Decitabine
Chemical. CAS 2353-33-5. Formula C8H12N4O4. MW 228.21. Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation hypomethylation and gene activation by remodeling "opening" chromatin. This cytosine analog incorporates into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a potent antileukaemic agent with activity in the treatment of haematological malignancies such as acute myeloid leukaemia AML, chronic myeloid leukaemia CML and myelodysplastic syndrome preleukaemia and has been suggested to reverse chemotherapy resistance in several cancer types. It is used as a chemotherapeutic agent, suppresses growth of human tumor cell lines, shown to reverse embryonic stem cell differentiation and prevent atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages.
AdipoGen Decitabine
Chemical. CAS 2353-33-5. Formula C8H12N4O4. MW 228.21. Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation hypomethylation and gene activation by remodeling "opening" chromatin. This cytosine analog incorporates into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a potent antileukaemic agent with activity in the treatment of haematological malignancies such as acute myeloid leukaemia AML, chronic myeloid leukaemia CML and myelodysplastic syndrome preleukaemia and has been suggested to reverse chemotherapy resistance in several cancer types. It is used as a chemotherapeutic agent, suppresses growth of human tumor cell lines, shown to reverse embryonic stem cell differentiation and prevent atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages.
Apexbio Technology LLC Itraconazole(Synonyms: Sporanox, Orungal, R51211, Lozanoc, Triasporin, Fungitraxx, Onmel, Itranox, Sporal, Itrizole, Candistat), 1g, CAS: 84625-61-6.
Itraconazole (CAS 84625-61-6) is a triazole-based antifungal compound that functions primarily by inhibiting cytochrome P450 enzymes particularly CYP3A4 As both a substrate and inhibitor of CYP3A4 itraconazole undergoes oxidative metabolism into hydroxylated keto- and N-dealkylated derivatives all with demonstrated inhibitory activities comparable or superior to the parent compound In addition to antifungal effects itraconazole inhibits the hedgehog signaling pathway and angiogenesis Due to its affinity for mammalian CYP-P450 enzymes itraconazole is frequently employed in drug interaction studies assessing CYP3A-mediated metabolism
Medchemexpress LLC Palbociclib impurity 20 | 1774898-55-3 | 99.9% | 308.34 | 5 MG
Palbociclib impurity 20 is an impurity of Palbociclib (HY-50767). It has a CAS No. of 1774898-55-3 and a Molecular Weight of 308.34. The chemical formula is C14H20N4O4 and it appears as a solid.
- High purity for reliable research
- Shipped at room temperature in continental US
- Powder can be stored at -20°C for 3 years or 4°C for 2 years
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Fostamatinib (disodium hexahydrate) | 914295-16-2 | 99.5% | 100 MG
Fostamatinib (disodium hexahydrate) is a chemical compound commonly used as a laboratory chemical and for the manufacture of substances. It appears as a white to gray solid with a high purity of 99.5%. It is recommended for sealed storage away from moisture at 4°C, or at -80°C for 6 months (-20°C for 1 month) when in solvent.
- Used in laboratory research
- Suitable for substance manufacturing
- High purity (99.5%)
- Recommended sealed storage at 4°C, away from moisture
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Shipping at room temperature if less than 2 weeks
- White to gray solid appearance
Medchemexpress LLC Ganoderic acid C1 | 95311-97-0 | 95.0% | 1 MG
Ganoderic acid C1 is a natural compound isolated from *G. lucidum*. It suppresses TNF-α production by murine macrophages (RAW 264.7 cells).
- Isolated from *G. lucidum*
- Suppresses TNF-α production
- Targets TNF receptor
- Inhibits apoptosis pathway
Apexbio Technology LLC Isoprenaline HCl(Synonyms: Isoproterenol hydrochloride, Isoprenaline hydrochloride, Isadrine), 1g, CAS: 51-30-9.
Isoprenaline hydrochloride (CAS 51-30-9) is a synthetic sympathomimetic amine functioning as a non-selective -adrenoceptor agonist structurally analogous to epinephrine Its mechanism involves the stimulation of both 1- and 2-adrenergic receptors resulting in increased cardiac output through enhanced chronotropic and inotropic effects alongside bronchial smooth muscle relaxation Due to these pharmacological properties isoprenaline hydrochloride is utilized in research exploring cardiac arrhythmias conduction disorders bradycardia and bronchospasm
Medchemexpress LLC Carbidopa | 28860-95-9 | 99.8% | 100 MG
Carbidopa is a peripheral decarboxylase inhibitor used in Parkinson's disease research. It acts as a selective aryl hydrocarbon receptor (AhR) modulator and has shown to inhibit pancreatic cancer cell and tumor growth.
- Peripheral decarboxylase inhibitor
- Used in Parkinson's disease research
- Selective aryl hydrocarbon receptor (AhR) modulator
- Inhibits pancreatic cancer cell and tumor growth
Sigma Aldrich Fine Chemicals Biosciences Glyburide Related Compound A United States Pharmacopeia (USP) Reference Standard | 16673-34-0 | MFCD00193756 | 25MG
Glyburide Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 368.84 | 16673-34-0 | MFCD00193756 | 25MG
Cayman Chemical HarpagosIde 50mg
An iridoid glycoside with diverse biological activities; inhibits LPS-induced increases in COX-2 and NO levels, as well as TNF mRNA expression in HepG2 cells from 50-200 µM; reduces synovial inflammation, joint destruction, and bone erosion in a mouse model of collagen-induced arthritis at 10 mg/kg; decreases substantia nigra pars compacta neuronal cell death and increases time spent on the rod in a rotarod test in a mouse model of MPTP-induced Parkinson’s disease
Sigma Aldrich Fine Chemicals Biosciences Colchicine 95 HPLC powder1G
Colchicine is a secondary metabolite which has anti-inflammatory properties. It is used to treat gout crystal-induced joint inflammation familial Mediterranean fever BehA§et disease vasculitides andnbsppericarditis. Colchicine inhibits cell division intracellular vesicle motility secretion of cytokines andnbspchemokines. It is implicated innbspleukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.
Apexbio Technology LLC Alverine Citrate 5560-59-8 10mM (in 1mL DMSO)
Alverine citrate (CAS 5560-59-8) is a synthetic small-molecule compound employed primarily in studies of functional gastrointestinal disorders It exerts antispasmodic effects predominantly via calcium channel blockade reducing smooth muscle contraction and alleviating gastrointestinal symptoms Biomedical researchers utilize alverine citrate to examine gut motility mechanisms visceral hypersensitivity pathways and potential therapeutic approaches for gastrointestinal dysfunction
Medchemexpress LLC Clevudine (L-FMAU) | 163252-36-6 | 99.8% | 260.22 | 50 MG
Clevudine (L-FMAU) is a nucleoside analog of the unnatural L-configuration with potent anti-HBV activity, long half-life, and low toxicity. It acts as a non-competitive inhibitor that binds to the polymerase rather than being incorporated into the viral DNA. Clevudine is also active against cowpox virus respiratory infection in mice.
- Potent anti-HBV activity
- Long half-life
- Low toxicity
- Acts as a non-competitive inhibitor
- Active against cowpox virus respiratory infection in mice
Sigma Aldrich Fine Chemicals Biosciences Emetine dihydrochloride50MG
hydrochloride Emetine dihydrochloride50MG