Acetylides
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 5 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
eMolecules Broadpharm / Bis-propargyl-PEG10 / 250mg / 296213608 / BP-22828 / 98.000 / 1351373-47-1 / MFCD28976686 / 490.590 / C24H42O10
Broadpharm / Bis-propargyl-PEG10 / 250mg / 296213608 / BP-22828 / 98.000 / 1351373-47-1 / MFCD28976686 / 490.590 / C24H42O10
Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 98.9% | 143.18 g/mol | C7H13NO2 | 500 MG
Propargyl-PEG2-amine is a PEG-based linker used as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PEG-based PROTAC linker. It is supplied as a liquid reagent for bioconjugation and medicinal chemistry applications.
- Non-cleavable ADC and PROTAC linker for bioconjugation.
- PEG2 spacer with propargyl and amine functional groups.
- High purity (98.9%) suitable for synthesis.
- Liquid appearance, colorless to light yellow.
- Molecular weight 143.18 g/mol; formula C7H13NO2.
- Storage: refrigerate at 4°C, protect from light; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
eMolecules 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1218790-49-8 | MFCD11113041 | 1g
Combi-Blocks | 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1g | 117546930 | PN-9139 | 96.000 | 1218790-49-8 | MFCD11113041 | 285.150 | C16H20BNO3
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Medchemexpress LLC O-Propargyl-Puromycin | 1416561-90-4 | 98.4% | 495.53 | 50 MG
O-Propargyl-Puromycin is a potent protein synthesis inhibitor and an alkyne analog of puromycin. It functions as a click chemistry reagent, featuring an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Protein synthesis inhibition: It effectively inhibits protein synthesis in both reticulocyte lysates and cultured cells.
- Covalent conjugates: This compound forms covalent conjugates with nascent polypeptide chains.
- Rapid turnover: These conjugates are rapidly turned over by the proteasome.
- Visualization and capture: The covalent conjugates can be visualized or captured through copper(I)-catalyzed azide-alkyne cycloaddition.
- Imaging and affinity purification: It can be utilized to image and affinity-purify nascent proteins within cells and animals.
eMolecules 4-Chloro-3-(trifluoromethoxy)phenol | 886500-85-2 | MFCD06660247 | 1g
Apollo Scientific | 4-Chloro-3-(trifluoromethoxy)phenol | 1g | 562453315 | PC302060 | 98.000 | 886500-85-2 | MFCD06660247 | 212.550 | C7H4ClF3O2
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Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 1 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 1 G
Propargyl-PEG8-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This compound is instrumental in developing PROTACs, which are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Interacts with Azide groups
- Facilitates selective degradation of target proteins
Medchemexpress LLC Propargyl-PEG7-Boc | 1818294-29-9 | >95% | 1 G
Propargyl-PEG7-Boc is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of a series of PROTACs.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTACs
- Purity >95%
- Soluble in DCM, DMF, DMSO
- Appearance: Pale yellow or colorless oily liquid
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 1 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of proteolysis targeting chimeras (PROTACs)
- Contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Propargyl-peg2-oh | 7218-43-1 | 99.66% | 5 G
Propargyl-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of Thalidomide-O-PEG2-propargyl. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. It has a molecular weight of 144.17 and a formula of C7H12O3. It appears as a colorless to light yellow liquid with a density of 1.06 g/cm3 and a purity of 99.66%.
- Peg-based protac linker
- Utilized in the synthesis of thalidomide-o-peg2-propargyl
- Click chemistry reagent
- Contains an alkyne group for cuaac reactions
- Intended for research use only
- Soluble in ethanol (≥ 100 mg/ml)
Medchemexpress LLC Propargyl-peg1-acid | 55683-37-9 | 97.0% | 250 MG
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs and functions as a click chemistry reagent. This product incorporates an Alkyne group which can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Utilized in the synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Incorporates an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)