Acetylides
Medchemexpress LLC Propargyl-PEG2-NHS ester | 2512228-06-5 | ≥98.0% | 269.25 g/mol | 100 MG
This PEG-based linker is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), which are molecules that utilize the ubiquitin-proteasome system to degrade target proteins. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Functions as a linker in targeted protein degradation research.
- Acts as a click chemistry reagent.
- Contains an alkyne functional group for specific reactions.
- Can undergo copper-catalyzed azide-alkyne cycloaddition.
- Enables conjugation with azide-containing molecules.
- Offers high purity for reliable experimental results.
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 1 G
Propargyl-PEG7-NHS ester is an alkyne-functional PEG7 N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation. It couples to primary amines via NHS chemistry and provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, making it suitable for ADC, PROTAC, and general labeling applications.
- Alkyne-functional terminal enables click chemistry.
- NHS ester reacts with primary amines for covalent coupling.
- PEG7 spacer increases solubility and provides flexibility.
- Molecular weight about 489.51 g/mol and formula C22H35NO11.
- Typical applications include ADC linkers, PROTAC synthesis, and peptide or protein labeling.
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 100 MG
Propargyl-PEG7-NHS ester is an alkyne-containing PEG7 NHS ester linker used for bioconjugation and chemical conjugation workflows. It is used as a cleavable ADC linker, a PROTAC linker, and as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne-functional NHS ester for CuAAC click chemistry.
- PEG7 spacer provides hydrophilicity and flexibility.
- Suitable for synthesis of PROTACs and antibody-drug conjugates.
- Amine-reactive NHS ester enables conjugation to lysine residues.
- Available in small research pack sizes (100 mg, 250 mg, 1 g).
Medchemexpress LLC VQW-765 | 669770-29-0 | MFCD28502153 | 99.6% | 294.39 g/mol | C19H22N2O | 10 MG
VQW-765 is an orally active, selective partial agonist of the α7 nicotinic acetylcholine receptor (α7-nAChR) developed for preclinical research into anxiety and related CNS disorders. Supplied as a pre-weighed 10 mg research reagent, it is intended for use in in vitro and in vivo studies and is not for human consumption.
- Selective α7 nicotinic acetylcholine receptor partial agonist.
- Orally active compound suitable for in vivo dosing.
- High chemical purity (approximately 99.6%).
- Supplied as a pre-weighed 10 mg quantity for dosing convenience.
- Appropriate for both in vitro and in vivo pharmacology studies.
- Research use only; not for human or clinical use.
Medchemexpress LLC (S)-VQW-765 ((S)-AQW-051) | 98.0% | 294.39 | 5 MG
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective, and effective α7 nicotinic ACh receptor (nAChR) partial agonist. It has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia.
- Orally active, selective, and effective α7 nAChR partial agonist
- Potential applications in cognitive disorders
- Suitable for neurological diseases like Alzheimer's or schizophrenia
Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 98.9% | 143.18 g/mol | C7H13NO2 | 500 MG
Propargyl-PEG2-amine is a PEG-based linker used as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PEG-based PROTAC linker. It is supplied as a liquid reagent for bioconjugation and medicinal chemistry applications.
- Non-cleavable ADC and PROTAC linker for bioconjugation.
- PEG2 spacer with propargyl and amine functional groups.
- High purity (98.9%) suitable for synthesis.
- Liquid appearance, colorless to light yellow.
- Molecular weight 143.18 g/mol; formula C7H13NO2.
- Storage: refrigerate at 4°C, protect from light; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
eMolecules 3-Ethoxy-5-(trifluoromethoxy)phenylboronic acid | 1256345-87-5 | MFCD16295059 | 1g
Combi-Blocks | 3-Ethoxy-5-(trifluoromethoxy)phenylboronic acid | 1g | 117524556 | BB-6330 | 97.000 | 1256345-87-5 | MFCD16295059 | 249.980 | C9H10BF3O4
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Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 500 MG
Propargyl-PEG3-bromide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Bis-propargyl-PEG4 | 159428-42-9 | 95.6% | 5 G
Bis-propargyl-PEG4 is a PEG-based bifunctional linker featuring terminal propargyl (alkyne) groups, designed for conjugation chemistry and PROTAC construction. It provides a short, flexible spacer for joining two ligands via click chemistry.
- Bifunctional PEG4 linker with terminal alkyne groups.
- Enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Useful for PROTAC synthesis and dimer formation.
- Low molecular weight (270.32 g/mol) for compact linker design.
- Stable under recommended storage conditions when kept dry and refrigerated.
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 100 MG
Propargyl-PEG8-acid is a propargyl-functionalized polyethylene glycol (PEG8) carboxylic acid linker designed for bioconjugation and linker chemistry. It provides a PEG8 spacer with a terminal alkyne for click chemistry and a carboxylic acid for coupling reactions; it is supplied as a high-purity solid with defined stability and storage requirements.
- Propargyl terminal alkyne suitable for copper-catalyzed click chemistry.
- Peg8 spacer improves solubility and flexibility in conjugates.
- Carboxylic acid functionality enables amide coupling and derivatization.
- High purity (approximately 98.0%) for reliable synthetic performance.
- Molecular weight 436.49 g/mol, formula C20H36O10.
- Available in small-scale packs (100 mg) and larger sizes for scale-up.
- Store at -20°C under inert atmosphere; in solvent, follow recommended cold storage times.
eMolecules 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1218790-49-8 | MFCD11113041 | 1g
Combi-Blocks | 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1g | 117546930 | PN-9139 | 96.000 | 1218790-49-8 | MFCD11113041 | 285.150 | C16H20BNO3
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Sigma Aldrich Fine Chemicals Biosciences Cyclopropylacetylene Neat, 97% | 6746-94-7 | MFCD02181090 | 25G
Cyclopropylacetylene Neat, 97% | Purity: 97% | Mol Wt: 66.1 | 6746-94-7 | MFCD02181090 | 25G
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 60 mL Glass (Septum)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 38.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C