Acetylides
Medchemexpress LLC Propargyl-PEG12-OH 50mg | 1036204-61-1 | 584.69 | C27H52O13 | 50 MG
Propargyl-PEG12-OH is a PEG12-based linker bearing a terminal propargyl (alkyne) group and a hydroxyl terminus, intended for use as a click-chemistry-compatible spacer in PROTAC synthesis and bioconjugation. It has a molecular weight of 584.69 and CAS 1036204-61-1, and is supplied as a small laboratory vial.
- Terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- PEG12 spacer increases flexibility and aqueous solubility.
- Hydroxyl terminus enables further functionalization or conjugation.
- Analytical purity ≥98.0% (NMR) suitable for synthetic applications.
- Recommended storage: pure form -20°C (3 years) or 4°C (2 years).
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | >98.0% | 407.50 g/mol | C19H37NO8 | 50 MG
Propargyl-PEG8-NH2 is a heterobifunctional PEG8 linker featuring a terminal propargyl (alkyne) group and a primary amine; it is used for click chemistry (CuAAC) and amine derivatization in bioconjugation workflows such as PROTAC and ADC synthesis.
- Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
- Contains a primary amine for further derivatization and amide or carbamate coupling.
- Formula C19H37NO8 and molecular weight 407.50 g/mol.
- High purity, specified as ≥98.0%.
- Common applications include ADC linkers, PROTAC linkers, and general bioconjugation building blocks.
- CAS number 1196732-52-1 for chemical identification.
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) hex-5-ynoate | 906564-59-8 | MFCD28898858 | 97.0% | 209.20 g/mol | C10H11NO4 | 50 MG
Propargyl-C2-NHS ester is an alkyne-containing N-hydroxysuccinimide (NHS) ester used for bioconjugation. It serves as a non-cleavable linker and a click-chemistry reagent enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-bearing molecules.
- Contains a propargyl (alkyne) group for CuAAC reactions.
- Designed for antibody conjugation and general bioconjugation.
- Molecular formula C10H11NO4; molecular weight 209.20 g/mol.
- High purity: 97.0%.
- Stored at -20°C in pure form; available in small pack sizes for research use.
![Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | ≥95.0% | 264.36 g/mol | C10H16O4S2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203722.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | ≥95.0% | 264.36 g/mol | C10H16O4S2 | 50 MG
Cleavable two-unit polyethylene glycol (PEG) linker with a terminal propargyl (alkyne) group for click chemistry and antibody-drug conjugate (ADC) synthesis. It contains a reducible disulfide linkage and is suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC). Supplied with ≥95.0% purity; molecular weight 264.36 g/mol; CAS 1807503-85-0.
- Cleavable disulfide linker enabling cytosolic release
- Terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
- Two-unit PEG spacer improves solubility and linker flexibility
- High purity suitable for conjugation reactions
- Available in multiple package sizes for research use
TARGETMOL CHEMICALS INC O-Propargyl-Puromycin 1MG
Also available in 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog. Purity 99.7%
TARGETMOL CHEMICALS INC AZ 628 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AZ628 is a new pan-Raf inhibitor for BRAF BRAFV600E and c-Raf-1 with IC50 of 105 nM 34 nM and 29 nM also inhibits VEGFR2 DDR2 Lyn Flt1 FMS etc. purity: 98%
Medchemexpress LLC Propargyl-C2-NHS ester | 906564-59-8 | 97.0% | 209.20 | C10H11NO4 | 250 MG
Propargyl-C2-NHS ester is a noncleavable linker and click-chemistry reagent containing a terminal alkyne (propargyl) group used to introduce an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC) bioconjugation and in antibody-drug conjugate (ADC) linker synthesis.
- Purity 97.0%.
- Molecular weight 209.20 g/mol.
- Chemical formula C10H11NO4.
- Appearance colorless to off-white solid-liquid mixture.
- Storage pure form: -20°C (3 years); in solvent or stock solution: -80°C (6 months) or -20°C (1 month).
- Available sizes 50 mg to 50 g, including a 250 mg quantity.
Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | 98.7% | 224.28 g/mol | C11H12O3S | 10 G
An alkyne-bearing p-toluenesulfonate ester used as a click-chemistry reagent and cleavable linker for antibody-drug conjugate synthesis; it undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Reacts in copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Molecular formula C11H12O3S; molecular weight 224.28 g/mol.
- CAS number 23418-85-1.
- Purity typically 98.7%.
- Appearance colorless to light yellow liquid.
- Available in 1 g, 5 g, 10 g, and 50 g package sizes.
Medchemexpress LLC Bis-propargyl-PEG8 50mg | 1092554-87-4 | 50 MG
Bis-propargyl-PEG8 is a polyethylene glycol-based bifunctional linker bearing terminal propargyl (alkyne) groups. It functions as a flexible PEG8 spacer for click-chemistry conjugations, PROTAC construction, and other bioconjugation applications.
- Contains two terminal propargyl (alkyne) groups for CuAAC click reactions.
- PEG8 spacer provides flexibility and increased hydrophilicity.
- Applicable to PROTAC and ADC linker synthesis and general bioconjugation workflows.
- Supplied as a solid, commonly offered in milligram quantities such as 50 mg.
- Characterized by chemical formula C22H38O9 and molecular weight 446.53 g·mol-1.
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | MFCD01346226 | 100.0% | 1083.12 | C54H63FN8O15 | 100 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugates (ADCs) that links an ADC linker to the DNA topoisomerase I inhibitor DXd and provides a propargyl handle for bioorthogonal conjugation.
- Molecular formula: C54H63FN8O15
- Molecular weight: 1083.12
- Cas number: 2762518-94-3
- Purity: 99.99%
- Appearance: solid, off-white to light yellow
- Storage: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- Package size: available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg; larger sizes available by quote
Medchemexpress LLC 4,7,10,13-Tetraoxahexadec-15-ynoic acid | 1415800-32-6 | 97.0% | 5 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs. It also serves as a click chemistry reagent, featuring an Alkyne group capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Supports synthesis of BTK-IAP PROTACs
- PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells
- Functions as a click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Appearance: Colorless to light yellow viscous liquid
- Molecular weight: 260.28
- Molecular formula: C12H20O6
- Solubility in DMSO: 50 mg/mL (192.10 mM)
Medchemexpress LLC HY-43721 10mg Medchemexpress, N-Boc-4-pentyne-1-amine CAS:151978-50-6 Purity:>98%
Medchemexpress, HY-43721 10mg N-Boc-4-pentyne-1-amine CAS:151978-50-6 N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.