Hydrochlorides
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 5 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes, enhancing glutamate sensitivity of mGlu5 likely due to interaction at a site on the receptor distinct from the MPEP binding site.
- Positive and highly selective mGlu5R allosteric modulator
- EC50 of 33 nM for mGlu5 receptor
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
Apexbio Technology LLC VU 0364439 1246086-78-1 5mg
VU 0364439 (CAS 1246086-78-1) is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) a member of the class C G protein-coupled receptor (GPCR) family involved in regulating glutamatergic neurotransmission In vitro studies have demonstrated that VU 0364439 enhances mGluR4 activity with an EC50 of 19 8 nM exhibiting greater maximal response and potency compared to the partially selective PAM ()-PHCCC Although its pharmacokinetic properties limit in vivo applications VU 0364439 serves as a valuable tool compound for investigating mGluR4 function and modulation in cellular assays
Selleck Chemical LLC Tirofiban S3085-5mg
Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM
Matrix Scientific 4-(CHLOROMETHYL)PYRIDINEHY-25G
4-(Chloromethyl)pyridinehydrochloride, 98%; 25g,C6H7Cl2N, MFCD00012826, mw 164.04, [1822-51-1]
Matrix Scientific 2-(CHLOROMETHYL)PYRIDINE H-25G
2-(Chloromethyl)pyridine hydrochloride, 98%; 25g,C6H7Cl2N, MFCD00012811, mw 164.04, [6959-47-3]
Apexbio Technology LLC Doxepin (hydrochloride) 1229-29-4 10mM (in 1mL DMSO)
Doxepin (hydrochloride) (CAS 1229-29-4) is a tricyclic antidepressant that functions as a potent antagonist of the histamine H1 receptor a G protein coupled receptor expressed in tissues such as smooth muscle vascular endothelium cardiac tissue and the central nervous system In vitro doxepin acts as a competitive inhibitor of serotonin uptake in human platelets with a reported Ki of approximately 0 2 M and can induce rapid serotonin efflux at higher concentrations In vivo studies in rodents and canines demonstrate efficient oral absorption and metabolic conversion in liver and urine with central nervous system penetration observed in rats Doxepin is widely used in research related to neurotransmitter modulation and histaminergic signaling
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | 99.9% | 495.07 | 5 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. It induces proliferation and migration on endothelial cells by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding to the receptor
- Possesses antithrombotic activity
- Induces proliferation and migration on endothelial cells
- Significantly reduces myocardial no-reflow
- Alleviates myocardial microvascular structural and endothelial dysfunction
Medchemexpress LLC Iso-H7 (dihydrochloride) | 140663-38-3 | 99.1% | 364.29 | 10 MG
Iso-H7 dihydrochloride is a protein kinase inhibitor that exhibits IC50 values of 22 and 34 μM for PKC and PKA, respectively. It also acts as a negative control for PKA in satellite cell myogenesis. This product is intended for research use only and is not sold to patients.
- Inhibitor of protein kinase.
- Specifically inhibits PKC with an IC50 of 22 μM and PKA with an IC50 of 34 μM.
- Demonstrates negative control of PKA on satellite cell myogenesis.
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 10 MM 1 ML
Icotinib Hydrochloride is a potent, CNS-penetrant, and specific Epidermal Growth Factor Receptor (EGFR) inhibitor. It is effective against various mutant forms of EGFR and functions as a click chemistry reagent due to its Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition with Azide groups. This compound inhibits the proliferation of several cancer cell lines and demonstrates dose-dependent antitumor effects in animal models.
- Potent and specific EGFR inhibitor
- Effective against mutant EGFR forms
- Functions as a click chemistry reagent
- Inhibits kinase activity and tumor cell proliferation
- Exhibits dose-dependent antitumor effects in vivo
- Well-tolerated in animal studies
- Investigated in clinical trials for Non-Small Cell Lung Cancer and other conditions