Hydrochlorides
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 100 MG
RS-127445 hydrochloride is a selective, high-affinity, and orally bioavailable 5-HT2B receptor antagonist. It exhibits 1000-fold selectivity for the 5-HT2B receptor compared to numerous other receptor and ion channel binding sites, making it a valuable tool for research into serotonin receptor activity and related biological pathways.
- Selective and high-affinity 5-HT2B receptor antagonist
- Orally bioavailable
- Exhibits 1000-fold selectivity over many other receptors
- Potently blocks 5-HT evoked increases in intracellular calcium concentrations
- Reduces faecal output in rats dose-dependently
Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
Medchemexpress LLC DAPI dihydrochloride (4',6-Diamidino-2-phenylindole) | 28718-90-3 | 99.9% | 50 MG
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a fluorescent dye that strongly binds to double-stranded DNA at AT base pairs, causing a significant increase in fluorescence intensity. This property makes it widely used in fluorescence microscopy for DNA quantification and cell staining, capable of penetrating intact cell membranes. It also functions as an ASIC3 inhibitor and is explored in chronic pain treatment research.
- Binds strongly and specifically to DNA.
- Increases fluorescence intensity upon DNA binding.
- Used in fluorescence microscopy for DNA quantification.
- Stains both live and fixed cells by penetrating cell membranes.
- Acts as an acid-sensing ion channel 3 (ASIC3) inhibitor.
- Applicable in chronic pain treatment research.
- For research use only.
Medchemexpress LLC Zt 52656a hydrochloride | 115730-24-0 | MFCD00673899 | 100.0% | 390.87 g·mol⁻¹ | C19H26ClF3N2O | 100 MG
ZT 52656A hydrochloride is the hydrochloride salt of a selective kappa opioid receptor agonist used in research to investigate kappa-mediated analgesia and the prevention or alleviation of ocular pain. Supplied as a white to off-white solid for laboratory applications, it is intended for research use only and not for clinical or human use.
- Selective kappa opioid receptor agonist.
- High reported purity (99.98%).
- Molecular weight 390.87 g·mol⁻¹.
- White to off-white solid suitable for analytical and in vivo studies.
- Recommended storage: 4°C sealed; in solvent: -80°C up to 6 months, -20°C up to 1 month.
- Available in multiple package sizes, including 100 mg.
Medchemexpress LLC 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride | 1123491-15-5 | 99.1% | 339.22 | 10 MG
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM. It is for research use only and not sold to patients.
- Potent and selective inhibitor of human PDGFRβ.
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | MFCD00079224 | 99.7% | 269.77 g/mol | C14H20ClNO2 | 50 MG
Piperoxan hydrochloride is a small-molecule research reagent that functions as an α2 adrenoceptor antagonist and an early-generation antihistamine. Supplied as the hydrochloride salt in high purity, it is used in receptor pharmacology, GPCR studies, and biochemical assays, and is commonly provided as small solid quantities or prepared DMSO stock solutions.
- α2 adrenoceptor antagonist activity suitable for receptor pharmacology studies.
- First-generation antihistamine properties for comparative pharmacology.
- High purity (manufacturer-reported ~99.7%) appropriate for biochemical assays.
- Available as small solid quantities and as prepared DMSO solutions for convenience.
- Molecular formula C14H20ClNO2 and molecular weight 269.77 g/mol.
- Safety and quality documents available, including SDS and COA.