Hydrochlorides
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 1804978-82-2 | 99.8% | 688.66 | 100 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. It ameliorates narcolepsy-cataplexy symptoms in mouse models and increases wakefulness in mice.
- Selective OX2R agonist
- Ameliorates narcolepsy-cataplexy symptoms
- Increases wakefulness
Chemscene ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
Medchemexpress LLC HBED dihydrochloride | 35369-53-0 | MFCD04113603 | ≥95.0% | 461.34 g·mol⁻¹ | C20H26Cl2N2O6 | 250 MG
HBED dihydrochloride (CAS 35369-53-0) is an orally active, hexadentate phenolic aminocarboxylate iron chelator used in biochemical and pharmacological research to model iron binding and to study iron-overload in preclinical systems. Supplied as a white to off-white solid dihydrochloride salt, it is characterized by formula C20H26Cl2N2O6 and molecular weight 461.34 g·mol⁻¹.
- Orally active hexadentate iron chelator.
- Useful for in vitro and in vivo iron chelation studies.
- White to off-white solid form, easy to handle and weigh.
- Molecular formula C20H26Cl2N2O6; molecular weight 461.34 g·mol⁻¹.
- High purity suitable for research applications (product documentation shows ≥95.0% with a reported 91.66% data-sheet variant).
Medchemexpress LLC Roxindole hydrochloride | 108050-82-4 | 99.5% | 382.93 g·mol⁻1 | C23H27ClN2O | 50 MG
Roxindole hydrochloride is a research-grade small molecule used as a pharmacological tool to study serotonin and dopamine receptor activity. It functions as a 5-HT1A agonist and dopaminergic modulator and is provided as a hydrochloride salt for use in in vitro and biochemical assays.
- Used to probe 5-HT1A and dopamine receptor pharmacology
- High purity suitable for research assays (HPLC)
- Molecular weight 382.93 g·mol⁻1
- Chemical formula C23H27ClN2O; CAS 108050-82-4
- Available in small solid quantities for laboratory experiments
- Store solid at -20°C and protect from light
Medchemexpress LLC Phenibut hydrochloride | 3060-41-1 | MFCD00075860 | >98.0% | 215.68 g/mol | C10H14ClNO2 | 100 G
Phenibut hydrochloride is a GABAB receptor agonist supplied as a white to off-white powder for research use. It is used in pharmacology and neuroscience studies investigating GABAergic signaling, anxiolytic effects, and cognition-related research.
- Purity ≥98.0%.
- CAS number 3060-41-1.
- Molecular formula C10H14ClNO2.
- Molecular weight 215.68 g/mol.
- Physical form: white to off-white powder.
- Available in laboratory package sizes up to 100 g.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 100 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation at concentrations of 0.1 and 1.0 μM.
- Neuroprotective in a mouse model of Huntington's disease.
- For research use only, not for sale to patients.
Medchemexpress LLC Sb-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g·mol⁻¹ | C18H23ClIN3O3S | 5 MG
SB-258585 hydrochloride is the hydrochloride salt of a selective, high-affinity antagonist for the serotonin 5-HT6 receptor. Supplied as a research-grade powder, it is intended for in vitro receptor binding and pharmacology studies and is characterized by high purity and defined storage conditions.
- Selective 5-HT6 receptor antagonist with high affinity.
- Suitable for in vitro receptor binding and pharmacological assays.
- Provided as a hydrochloride salt in powder form for accurate dosing.
- High purity (>99.7%) for reproducible results.
- Stable when stored under recommended conditions (powder: -20°C).
Medchemexpress LLC Ipn60090 dihydrochloride | 2102101-72-2 | 99.7% | 605.44 g/mol | C24H29Cl2F3N8O3 | 1 ML
IPN60090 dihydrochloride is a potent, selective small-molecule inhibitor of glutaminase 1 (GLS1), provided as a dihydrochloride salt for preclinical research. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid samples, with reported high purity and documented in vitro and in vivo activity supporting use in solid tumor studies.
- Highly selective GLS1 inhibitor with reported IC50 = 31 nM.
- Inhibits A549 cell proliferation (IC50 = 26 nM).
- Available as 10 mM solution in DMSO (1 mL) or multiple solid sizes for experimental flexibility.
- High purity suitable for biochemical and cell-based assays.
- Documented pharmacokinetic and efficacy data in preclinical models.
![Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437403-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 50 MG
1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] is a lipid/lipidoid chemical compound primarily used in the preparation of lipid-based or lipidoid nanoparticles. This product is for research use only.
- Solid appearance, light yellow to orange in color.
- Suitable for lipid-based or lipidoid nanoparticle preparation.
- High purity of 98.0%.
- Soluble in DMSO.
- Specific storage conditions for powder and solutions to maintain stability.
Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 10 MG
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor with a Ki of 0.5 nM. It exhibits slight selectivity over p38β (Ki=36 nM) and a greater than 1000-fold selectivity against p38γ and p38δ. This compound is highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM) and also inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor (Ki=0.5 nM).
- Slightly selective over p38β (Ki=36 nM).
- Greater than 1000-fold selective against p38γ and p38δ.
- Potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 500 UG
XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. It has an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
- Potent Kv7 (KCNQ) channels blocker.
- Inhibits Kv7.1, Kv7.2, Kv7.2 + Kv7.3 channels, and M-current.
- IC50s: 0.75 μM (Kv7.1), 0.71 μM (Kv7.2), 0.6 μM (Kv7.2 + Kv7.3), 0.98 μM (M-current).
- EC50 of 490 nM for enhancing [3H]ACh release from rat brain slices.
- Good in vivo potency and duration of action.
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MG
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist. It demonstrates an IC50 of 32±3 nM in LLC-PK1 cells and a dissociation constant (Kb) of 19±6 nM. This compound does not induce intracellular calcium mobilization on its own.
- Antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a)
- IC50 of 32±3 nM in LLC-PK1 cells
- Dissociation constant (Kb) of 19±6 nM
- Does not induce intracellular calcium mobilization
- Attenuates phencyclidine (PCP)-induced deficits in prepulse inhibition in vivo
Medchemexpress LLC Dazoxiben (hydrochloride) | 74226-22-5 | MFCD00866791 | 99.9% | 268.70 | C12H13ClN2O3 | 10 MM 1 ML
Dazoxiben (hydrochloride) is the hydrochloride salt of dazoxiben, a potent and orally active thromboxane (TX) synthase inhibitor used in research to probe thromboxane-mediated pathways. Supplied as a concentrated solution for laboratory use, it includes accompanying safety and handling documentation.
- Potent thromboxane synthase inhibitor for research applications.
- Provided as a 10 mM solution in DMSO, ready for dilution.
- High purity (99.9%) suitable for biochemical assays.
- Storage guidance for sealed samples: -80°C (6 months) or -20°C (1 month) in solvent.
- SDS and data sheet available for handling and safety information.
Medchemexpress LLC PIM-447 dihydrochloride | 1820565-69-2 | MFCD30489747 | 99.3% | 513.38 | C24H25Cl2F3N4O | 10 MG
PIM-447 dihydrochloride is the dihydrochloride salt of a potent, orally available pan-PIM kinase inhibitor used in preclinical research. It modulates apoptosis and JAK/STAT signaling and has been investigated for antimyeloma and bone-protective effects. This reagent is supplied for laboratory research use only.
- Potent pan-PIM kinase inhibition with low picomolar Ki values.
- Demonstrated antimyeloma and bone-protective activity in preclinical studies.
- High solubility in water and DMSO (H2O: 50 mg/mL; DMSO: ≥46.7 mg/mL).
- High purity (≈99.3%).
- Provided as a 10 mg solid suitable for preparing concentrated stock solutions.
- Stability supported by recommended storage conditions in solvent (-80°C 1 year; -20°C 6 months).
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC Cyclohexylpiperazine derivative | 172907-03-8 | 99.6% | 443.49 | 100 MG
Cyclohexylpiperazine derivative | 172907-03-8 | 99.6% | 443.49 | 100 MG