Hydrochlorides
eMolecules 912999-79-2 | 5-Chloroisoindoline hydrochloride | Ambeed | MFCD11223562 | 190.07 | C8H9Cl2N | 98 | Cl.Clc1ccc2CNCc2c1 | 5g | 552537975
5-Chloroisoindoline hydrochloride | Ambeed | 912999-79-2 | MFCD11223562 | 190.070 | C8H9Cl2N | 98.000 | Cl.Clc1ccc2CNCc2c1 | 5g | 552537975
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 100 MG
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). It is also a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
- Na+/Ca2+ exchanger (NCX) inhibitor
- Non-selective Deg/epithelial sodium channels (ENaC) blocker
- Can potentiate myogenic vasoconstriction
- Inhibits TRPP3-mediated Ca2+-activated currents
eMolecules 89990-54-5 | Pyrazolidine dihydrochloride | A1 Biochem Labs | MFCD16620353 | 145.030 | C3H10Cl2N2 | 95.000 | Cl.Cl.C1CNNC1 | 1g | 283328635
Pyrazolidine dihydrochloride | A1 Biochem Labs | 89990-54-5 | MFCD16620353 | 145.030 | C3H10Cl2N2 | 95.000 | Cl.Cl.C1CNNC1 | 1g | 283328635
Medchemexpress LLC Lobeline hydrochloride | 134-63-4 | 99.97% | 10 MM * 1 ML
Lobeline hydrochloride, a brain-penetrant nicotinic receptor agonist, increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles and altering presynaptic DA storage. It is effective in smoking cessation and has potential in methamphetamine-related disorder research.
- Acts as a brain-penetrant nicotinic receptor agonist.
- Increases dopamine release by inhibiting its uptake into synaptic vesicles.
- Alters presynaptic dopamine storage.
- Effective for smoking cessation.
- Evokes dopamine overflow calcium-independently (0.1-100 μM).
- Inhibits dopamine uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM).
- Decreases d-methamphetamine self-administration in rats.
- Decreases d-methamphetamine responding and increases tolerance development.
- Supplied as a 10 mM solution in 1 mL of water.
TARGETMOL CHEMICALS INC Nisoxetine hydrochloride 25MG
Also available in 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor Purity 98.52%
Apexbio Technology LLC RS 127445 HCl 199864-87-4 5mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | MFCD00079224 | 99.7% | 269.77 | C14H20ClNO2 | 5 MG
Piperoxan hydrochloride is a small-molecule research reagent described as an α2 adrenoceptor antagonist and a first-generation antihistamine. Supplied as the hydrochloride salt (CAS 135-87-5), it is used in pharmacology and receptor-binding studies to probe adrenergic and histaminergic mechanisms.
- High purity research-grade small molecule (molecular weight 269.77).
- Acts as an α2 adrenoceptor antagonist for receptor pharmacology studies.
- Exhibits first-generation antihistamine properties relevant to histamine assays.
- Available in milligram-scale quantities suitable for in vitro research.
- Provided with SDS and COA documentation for handling and quality assurance.
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 1 ML
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
Medchemexpress LLC VU0360172 hydrochloride | 1309976-62-2 | 98.9% | 330.78 g/mol | C18H16ClFN2O | 100 MG
VU0360172 hydrochloride is a potent and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5), used in pharmacology and neuroscience research to probe mGlu5 signaling. Reported values include EC50 16 nM and Ki 195 nM. The compound is supplied as a white to off-white solid with high purity and recommended cold storage for stability.
- Potent mGlu5 activity (EC50 16 nM).
- Selective binding profile (Ki 195 nM for mGlu5).
- High purity suitable for research use (approximately 98.9%).
- Solid, white to off-white physical form for easy handling.
- Stable when stored cold (recommended -20°C; in solvent: -80°C for extended storage).
- Available in multiple small pack sizes for research workflows.
Selleck Chemical LLC RS-127445 S2698-50mg
RS-127445 (MT500) is a selective 5-HT2B receptor antagonist with pKi of 9 5 and pIC50 of 10 4 exhibits 1000-fold selectivity against other 5-HT receptors
Medchemexpress LLC 2,4-dichloro-5-(((2-((dimethylamino)methyl)phenyl)methoxy)methyl)pyrimidine hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 50 MG
DCPT1061 hydrochloride is a potent inhibitor of histone methyltransferases, specifically targeting PRMT1, PRMT6, and PRMT8 in vitro. It exhibits weak inhibitory effects on other epigenetic enzymes like PRMT3, PRMT4, and PRMT5. This compound has demonstrated antitumor effects, making it a promising agent for cancer research.
- Strong inhibitory effect on PRMT1, PRMT6, and PRMT8.
- Minimal inhibition of PRMT3, PRMT4, and PRMT5.
- Exhibits antitumor properties.
- Suitable for research applications.
eMolecules 1080640-91-0 | 8-(TRIFLUOROMETHYL)QUINOLIN-6-AMINE | AstaTech | MFCD11052592 | 212.175 | C10H7F3N2 | 95.000 | Nc1cc(c2ncccc2c1)C(F)(F)F | 1g | 410713139
8-(TRIFLUOROMETHYL)QUINOLIN-6-AMINE | AstaTech | 1080640-91-0 | MFCD11052592 | 212.175 | C10H7F3N2 | 95.000 | Nc1cc(c2ncccc2c1)C(F)(F)F | 1g | 410713139
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 | C13H17ClN2 | 10 MG
PNU-22394 hydrochloride is a research-grade small molecule agonist of serotonin (5-HT) receptors, reported as a 5-HT2C agonist and partial 5-HT2A/2B agonist. Supplied as the hydrochloride salt and provided at high purity for pharmacology and receptor biology studies in vitro and in vivo.
- Potent 5-HT2C agonist with reported Ki ≈ 6.1 nM and 5-HT2A activity ≈ 10 nM.
- Hydrochloride salt, suitable for dissolution in common assay solvents.
- Molecular formula C13H17ClN2 and molecular weight 236.74 g/mol.
- High purity (>98.7%), appropriate for research applications.
- Intended for pharmacological research and receptor characterization studies.