Hydrochlorides
Medchemexpress LLC Y13g dihydrochloride | 2766380-73-6 | 308.37 | 25 MG
Y13g is a potent inhibitor of both acetylcholinesterase (AChE) and interleukin-6 (IL-6). These are important targets implicated in the progression of Alzheimer's Disease (AD). Y13g has been shown to reverse STZ-induced memory deficit and exhibits histopathology similar to that of normal animals.
- Potent inhibitor of AChE.
- Potent inhibitor of IL-6.
- Reverses memory deficits induced by STZ.
- Exhibits histopathology similar to normal animals.
- Aids in Alzheimer's Disease research.
Medchemexpress LLC Iso-H7 (dihydrochloride) | 140663-38-3 | 99.1% | 364.29 | 10 MG
Iso-H7 dihydrochloride is a protein kinase inhibitor that exhibits IC50 values of 22 and 34 μM for PKC and PKA, respectively. It also acts as a negative control for PKA in satellite cell myogenesis. This product is intended for research use only and is not sold to patients.
- Inhibitor of protein kinase.
- Specifically inhibits PKC with an IC50 of 22 μM and PKA with an IC50 of 34 μM.
- Demonstrates negative control of PKA on satellite cell myogenesis.
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 | C21H30Cl2N2O3 | 50 MG
ZK756326 dihydrochloride is a nonpeptide agonist of the CC chemokine receptor CCR8 used as a research tool to study CCR8 signaling. It inhibits binding of the CCR8 ligand I-309 (CCL1) with an IC50 of 1.8 μM, functions as a full agonist that increases intracellular calcium, and stimulates extracellular acidification in CCR8-expressing cells.
- Nonpeptide CCR8 agonist for receptor activation studies.
- IC50 for CCR8 binding inhibition: 1.8 μM.
- Full agonist - induces dose-dependent intracellular calcium increase.
- Shows >28-fold specificity versus a 26-GPCR panel at 50 μM.
- Reduced selectivity observed versus certain serotonergic and α2A-adrenergic receptors.
- Purity 99.87%, white to off-white solid.
- Available as multiple solid sizes and 10 mM solution in DMSO.
- Storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month).
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 g/mol | C21H30Cl2N2O3 | 25 MG
ZK756326 dihydrochloride is a small-molecule, nonpeptide agonist of the CC chemokine receptor CCR8 supplied as the dihydrochloride salt for research use only. It is intended for in vitro pharmacology and preclinical studies where modulation of CCR8 signaling is required, and is provided with a defined formula, molecular weight, and high purity.
- Selective CCR8 agonist for receptor pharmacology studies.
- High purity suitable for analytical and biological assays (99.87%).
- Well-defined chemical identity with molecular formula and weight.
- Available in small pack sizes for laboratory research.
- For research use only; not for human or veterinary applications.
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Apexbio Technology LLC RS 127445 HCl 199864-87-4 5mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 500 MG
Azaphen dihydrochloride monohydrate, also known as Pipofezine or Azafen, is a potent inhibitor of serotonin reuptake. It functions as a tricyclic antidepressant (TCA) and is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Acts as a tricyclic antidepressant
- Used for the treatment of depression
eMolecules Medchem Express / Nisoxetine (hydrochloride) / 5mg / 533802639 / HY-B1704A / / 57754-86-6 / MFCD00153850 / 307.820 / C17H22ClNO2
Medchem Express / Nisoxetine (hydrochloride) / 5mg / 533802639 / HY-B1704A / / 57754-86-6 / MFCD00153850 / 307.820 / C17H22ClNO2
Medchemexpress LLC DRP1i27 dihydrochloride | 1453028-33-5 | C20H28Cl2N6O | 1 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Potent inhibitor of human Drp1
- Binds to the GTPase site of Drp1
- Targets mitochondrial fission in cell line models
- Offers protection against simulated ischemia-reperfusion injury
Apexbio Technology LLC RS 127445 199864-87-4 10mM (in 1mL DMSO)
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity