Hydrochlorides
Medchemexpress LLC Epertinib hydrochloride | 2071195-74-7 | >98.0% | 596.48 g/mol | C30H28Cl2FN5O3 | 1 ML
Epertinib hydrochloride is the hydrochloride salt of epertinib, a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 used in oncology research. The product is supplied as a 10 mM solution in DMSO (1 mL) and as solid powders; consult the datasheet and safety information for handling and purity details.
- Potent, reversible inhibitor of EGFR, HER2, and HER4.
- Suitable for in vitro and in vivo oncology research.
- Available as a 10 mM DMSO solution for ready-to-use assays.
- Also available as solid for formulation or long-term storage.
- Molecular weight 596.48 g/mol and CAS number 2071195-74-7.
Medchemexpress LLC SB 202190 hydrochloride | 350228-36-3 | MFCD28391789 | 99.7% | 367.80 g·mol⁻¹ | C20H15ClF3NO | 1 ML
SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor used in cell signaling and pharmacology research. It is commonly supplied in concentrated stock formats for convenient preparation of working solutions.
- Selective p38 MAPK inhibitor; p38α IC50 ≈ 50 nM, p38β2 IC50 ≈ 100 nM.
- Supplied in a 10 mM solution format (1 mL) for ready stock preparation.
- Molecular weight 367.80 g·mol⁻¹; formula C20H15ClF3NO.
- DMSO-soluble; may require sonication and warming (up to 60°C) for full dissolution.
- Storage in solvent: -80°C (up to 6 months) or -20°C (up to 1 month); keep sealed and dry.
- High purity (manufacturer reported ~99.7%) suitable for research applications.
Medchemexpress LLC 2-(2-benzofuranyl)-2-imidazoline hydrochloride | 89196-95-2 | MFCD00672666 | >=98.0% | 222.67 g/mol | C11H11ClN2O | 1 ML
RX 801077 hydrochloride (2-(2-benzofuranyl)-2-imidazoline hydrochloride) is a selective imidazoline I2 receptor (I2R) agonist supplied for research use. It is available as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL), and is commonly used in in vitro pharmacology and receptor-binding studies focused on inflammation and neuroprotection. Consult the safety data sheet for handling and storage.
- Selective imidazoline I2 receptor agonist.
- Available as solid powder and as a 10 mM solution in DMSO, 1 mL.
- High purity suitable for analytical and pharmacological studies.
- Molecular weight 222.67 g/mol; formula C11H11ClN2O.
- Intended for in vitro pharmacology, receptor binding, and neuroprotection research.
Chem-Impex International, Inc. N-Z-1,5-pentanediamine hydrochloride | 18807-74-4 | MFCD00270152 | 1G
N-Z-1,5-pentanediamine hydrochloride, 18807-74-4, MFCD00270152, 1G
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 | C11H17ClN2O3 | 25 MG
Nifenalol hydrochloride is a β-adrenergic receptor antagonist supplied as a white to off-white solid for research use. It is used in pharmacology and cardiac electrophysiology studies, including investigation of early afterdepolarization (EAD) effects. The compound is provided in milligram-scale packs and has manufacturer guidance for solid and solution storage.
- β-adrenergic receptor antagonist for pharmacological research.
- Useful for studying cardiac electrophysiology and EAD mechanisms.
- High reported purity suitable for laboratory assays (99.9%).
- White to off-white solid, stable under recommended storage.
- Available in milligram-scale pack sizes for small-scale experiments.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 | C14H22Cl2N2 | 10 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with an IC50 of 16 nM. Provided as a solid for research use, the compound has been used in cellular studies to modulate gene expression, induce autophagy markers, and inhibit proliferation in various cancer cell lines. Handle and store according to safety data sheet recommendations.
Medchemexpress LLC (S)-1-(4-bromo-6-pyrimidinyl)-N-(2,4-dichlorobenzyl)-2-(pyrrolidin-1-yl)ethan-1-amine hydrochloride | 885104-09-6 | 99.9% | 438.58 g·mol⁻¹ | C15H16BrCl3N4 | 50 MG
LY2389575 hydrochloride is the hydrochloride salt of a small-molecule negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), intended for preclinical research. It is supplied as a solid powder with high purity and defined storage conditions for long-term stability.
- Negative allosteric modulator of mGlu3 for preclinical research
- High purity (99.9%) suitable for analytical and biological assays
- Solid powder form for convenient handling and formulation
- Defined storage stability: powder -20°C up to 3 years or 4°C up to 2 years
- Molecular weight 438.58 g·mol⁻¹ and formula C15H16BrCl3N4
Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC PD 128907 hydrochloride | 112960-16-4 | MFCD01529976 | 99.5% | 285.77 | C14H20ClNO3 | 25 MG
PD 128907 hydrochloride is a potent and selective dopamine D3 receptor agonist supplied as a solid biochemical reagent for life-science research. It is used in pharmacology and neurobiology to probe D3-mediated signaling and dopaminergic mechanisms, and is provided at high purity in small pack sizes for laboratory experiments.
- Potent D3 receptor agonist with low-nanomolar activity.
- High selectivity over D2 receptors for receptor-specific studies.
- High purity suitable for research applications.
- Solid form with white to light yellow appearance.
- Available in multiple small pack sizes for dosing flexibility.
- Recommended sealed storage away from moisture to preserve stability.
Medchemexpress LLC TAK-960 dihydrochloride | 99.2% | 634.52 | 5 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also demonstrates inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and shows significant efficacy against various tumor xenografts.
- Orally available
- Selective inhibitor of polo-like kinase 1 (PLK1)
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against various tumor xenografts
- Causes accumulation of G2-M cells
- Leads to G2/M cell cycle arrest