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Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | MFCD00933882 | 99.5% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, a selective, orally active 5-HT2B receptor antagonist. It blocks 5-HT or BW723C86-induced ERK2 phosphorylation and has demonstrated antihypertensive activity in DOCA-salt hypertensive rat models. Supplied as a high-purity off-white to light-yellow solid for research use.
- Selective 5-HT2B receptor antagonist.
- Orally active compound suitable for in vivo studies.
- Inhibits 5-HT or BW723C86-induced ERK2 phosphorylation.
- Demonstrated antihypertensive effects in DOCA-salt hypertensive rats.
- High reported purity (99.5%).
- Soluble in DMSO at 5 mg/mL with ultrasonic assistance.
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![Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244527.png-250.jpg)
Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.
- Selective positive allosteric modulation of mAChR M5.
- EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
- Enhances acetylcholine-stimulated insulin secretion in human β-cells.
- Available as solid or as a 10 mM solution in DMSO for flexible application.
- High purity suitable for biochemical and cellular assays.