Hydrochlorides
Medchemexpress LLC Danp dihydrochloride | 99.3% | 10 MG
DANP dihydrochloride is a bulge base recognition probe that strongly and specifically binds to the single cytosine and thymine bulges. It can stabilize both single cytosine and thymine bulges in duplex DNA.
- Strongly and specifically binds to single cytosine and thymine bulges.
- Stabilizes both single cytosine and thymine bulges in duplex DNA.
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 | C13H17ClN2 | 10 MG
PNU-22394 hydrochloride is a research-grade small molecule agonist of serotonin (5-HT) receptors, reported as a 5-HT2C agonist and partial 5-HT2A/2B agonist. Supplied as the hydrochloride salt and provided at high purity for pharmacology and receptor biology studies in vitro and in vivo.
- Potent 5-HT2C agonist with reported Ki ≈ 6.1 nM and 5-HT2A activity ≈ 10 nM.
- Hydrochloride salt, suitable for dissolution in common assay solvents.
- Molecular formula C13H17ClN2 and molecular weight 236.74 g/mol.
- High purity (>98.7%), appropriate for research applications.
- Intended for pharmacological research and receptor characterization studies.
Medchemexpress LLC SKF-96365 hydrochlor 10mg
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC Dopamine (hydrochloride) | 62-31-7 | MFCD00012898 | 99.8% | 100 MG
Dopamine hydrochloride is a catecholamine neurotransmitter produced in the brain's substantia nigra, ventral tegmental area, and hypothalamus. It plays important roles in the brain and body. This compound acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
- Catecholamine neurotransmitter
- Produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain
- Plays several important roles in the brain and body
- Acts through D2 dopamine receptors
- Induces endocytosis of VEGFR2
- Critical for promoting angiogenesis
Medchemexpress LLC Amiloride hydrochloride dihydrate | 17440-83-4 | MFCD00211292 | 99.9% | 1 ML
Amiloride hydrochloride dihydrate is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). It also acts as a blocker of polycystin-2 (PC2; TRPP2) channel.
- Inhibits epithelial sodium channel (ENaC)
- Inhibits urokinase-type plasminogen activator receptor (uTPA)
- Blocks polycystin-2 (PC2; TRPP2) channel
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 g/mol | C13H17ClN2 | 5 MG
PNU-22394 hydrochloride is a research-grade small-molecule agonist of serotonin (5-HT) receptors, showing selectivity for 5-HT2C and activity at 5-HT2A. Supplied as a hydrochloride salt, it is intended for in vitro pharmacology and receptor signaling studies.
- Selective agonist at 5-HT2C with Ki = 6.1 nM.
- Also active at 5-HT2A (Ki = 10 nM).
- Assay-dependent EC50: 5-HT2C 7.7 nM (Fluo-4/Ca2+) and 0.12 μM (IP-One); 5-HT2A 23 nM (Fluo-4/Ca2+) and 0.21 μM (IP-One).
- Molecular formula C13H17ClN2; molecular weight 236.74 g/mol.
- High chemical purity (98.8%).
- Available in small milligram quantities for laboratory research.
eMolecules 21987-29-1 | 4,4-Difluoropiperidine | Apollo Scientific | MFCD03094281 | 121.131 | C5H9F2N | 97.000 | FC1(F)CCNCC1 | 1g | 600856207
4,4-Difluoropiperidine | Apollo Scientific | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 97.000 | FC1(F)CCNCC1 | 1g | 600856207
Medchemexpress LLC Asciminib hydrochlor 10mM 1mL | 2119669-71-3 | 10MM 1ML
Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor which inhibits Ba/F3 cells grown with an IC50 of 0 25 nM[1
eMolecules 80222-96-4 | 2-Aminopropanamide hydrochloride | MFCD00066144 | 1g
Ambeed | 2-Aminopropanamide hydrochloride | 1g | 588342319 | A291539 | 80222-96-4 | MFCD00066144 | 124.570 | C3H9ClN2O
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Medchemexpress LLC DMPQ dihydrochloride | 1123491-15-5 | 99.1% | 339.22 | 10 MG
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM. It is intended for research use only.
- Potent and selective inhibitor of human PDGFRβ.
Medchemexpress LLC Tas-103 dihydrochloride (BMS-247615 dihydrochloride) | 174634-09-4 | 98.5% | 406.31 | 1 ML
Tas-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, utilized for cancer research. It demonstrates activity on CCRF-CEM cells with an IC50 value of 5 nM and is highly cytotoxic to Lewis lung carcinoma (LLC) cells. It also inhibits the viability of HeLa cells.
- Dual inhibitor of DNA topoisomerase I/II.
- Demonstrates activity on CCRF-CEM cells with an IC50 value of 5 nM.
- Elevates levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits viability of HeLa cells, exhibiting an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation.
- Suppresses tumor growth in mice bearing Lewis lung carcinoma (LLC) cells in vivo.
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 50 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits various LOX isoforms and reduces the deposition and crosslinking of collagen I secreted by human fibroblasts. This compound, intended for research use only, appears as a white to off-white solid with 99.71% purity and can be dissolved in DMSO at 100 mg/mL.
- Specific and effective pan-LOX (lysyl oxidase) inhibitor
- Abolishes lysyl oxidase activity
- Inhibits various LOX isoforms (Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, rh LOXL4)
- Reduces deposition and crosslinking of collagen I
- White to off-white solid with 99.71% purity
- Soluble in DMSO at 100 mg/mL
![Medchemexpress LLC 3(2H)-pyridazinone, 4,5-dihydro-6-[4-(4-pyridinylamino)phenyl]-, hydrochloride | 98326-33-1 | 99.8% | 302.76 g/mol | C15H15ClN4O | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247664.png-250.jpg)
Medchemexpress LLC 3(2H)-pyridazinone, 4,5-dihydro-6-[4-(4-pyridinylamino)phenyl]-, hydrochloride | 98326-33-1 | 99.8% | 302.76 g/mol | C15H15ClN4O | 1 ML
Senazodan hydrochloride is the monohydrochloride salt of Senazodan (MCI 154), a Ca2+ sensitiser that also exhibits inhibitory activity against phosphodiesterase III (PDE III). It is provided for research use in biochemical and pharmacological studies and is supplied in solid and solution formats for assay applications.
- High purity (99.84%) as verified by certificate of analysis.
- Exact chemical identity: C15H15ClN4O, MW 302.76 g/mol, CAS 98326-33-1.
- Suitable for biochemical and pharmacological assays involving Ca2+ sensitization and PDE III modulation.
- Available as solid powder and as concentrated solution formats for convenient dosing.
- COA available for batch-specific quality and analytical data.
Medchemexpress LLC MLN120B dihydrochloride | 1782573-78-7 | C19H17Cl3N4O2 | 25 MG
MLN120B dihydrochloride is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. This compound has demonstrated effectiveness in inhibiting multiple myeloma cell growth both in vitro and in vivo, and is also applicable for research related to rheumatoid arthritis.
- Potent, ATP competitive, and orally active IKKβ inhibitor
- Inhibits multiple myeloma cell growth in vitro and in vivo
- Can be used for research of rheumatoid arthritis