Dimethyl Sulfoxide
Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mM (in 1mL DMSO), CAS: 755038-02-9.
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
Apexbio Technology LLC Nitrendipine 39562-70-4 10mM (in 1mL DMSO)
Nitrendipine (CAS number 39562-70-4) is a dihydropyridine derivative acting as a calcium channel antagonist that selectively inhibits L-type calcium channels By blocking calcium ion influx into vascular smooth muscle cells nitrendipine induces vasodilation and reduces peripheral vascular resistance thereby lowering arterial blood pressure Due to its vascular-selective calcium antagonism it serves as a pharmacological tool in cardiovascular research particularly for studying mechanisms of hypertension and calcium-dependent signaling pathways
Apexbio Technology LLC WP1066 857064-38-1 10mM (in 1mL DMSO)
WP1066 (CAS 857064-38-1) is a small molecule analog of AG490 and functions primarily as an inhibitor of Janus kinase 2 (JAK2) It disrupts JAK2 signaling by reducing phosphorylation and promoting degradation of the JAK2 protein thereby inhibiting downstream STAT3/STAT5 transcription factors and the phosphoinositide-3 kinase pathway WP1066 has demonstrated antiproliferative and pro-apoptotic activity in models of acute myeloid leukemia (AML) including patient-derived AML cells and AML cell lines (OCIM2 K562) Additionally WP1066 shows inhibitory effects against tumor growth and angiogenesis in renal cell carcinoma (RCC) model systems highlighting its potential for hematologic cancers and RCC therapeutic research
Medchemexpress LLC Cwi1-2 10 Mm - 1 Ml In Dmso | HY-153274-10MM-1ML DMSO
Cwi1-2 10 Mm - 1 Ml In Dmso
Apexbio Technology LLC c-Myc tag Peptide 2918768-02-0 10mM (in 1mL DMSO)
c-Myc tag peptide is a synthetic peptide with the amino acid sequence EQKLISEEDL corresponding to residues 410-419 at the C-terminal region of human c-Myc protein It serves as an epitope tag for recombinant protein expression enabling specific recognition and purification of fusion proteins using anti-c-Myc antibodies In immunoassays the peptide competitively binds to anti-c-Myc antibodies confirming antibody-antigen binding specificity and facilitating analysis of fusion proteins in Western blotting immunoprecipitation and immunofluorescence experiments c-Myc itself encodes a transcription factor regulating cellular processes such as proliferation growth apoptosis differentiation and stem-cell renewal pathways and is frequently overexpressed in cancers
Apexbio Technology LLC Rifapentine 61379-65-5 10mM (in 1mL DMSO)
Rifapentine is an antibiotic compound employed in the treatment of pulmonary tuberculosis an infectious disease primarily caused by Mycobacterium tuberculosis Rifapentine inhibits bacterial RNA polymerase thereby preventing RNA synthesis essential for bacterial replication and survival In vitro studies demonstrate that rifapentine possesses potent activity against intracellular M tuberculosis residing within human macrophages with reported MIC values ranging from 0 015 to 0 06 mg/ml Preclinical research indicates rifapentine accumulates extensively in host cells achieving higher intracellular concentrations than structurally related rifampin Clinically rifapentine administration schedules involve twice-weekly doses during the intensive phase of tuberculosis therapy followed by weekly dosing in the continuation phase Rifapentine is commonly investigated in pharmacological studies to assess efficacy and optimize dosing regimens in pulmonary tuberculosis treatment
Apexbio Technology LLC Org 27569 868273-06-7 10mM (in 1mL DMSO)
Org 27569 (CAS 868273-06-7) is an allosteric modulator targeting the cannabinoid CB1 receptor It enhances the binding of the agonist CP55940 to purified CB1 receptors while simultaneously inhibiting receptor functionality In electrically-stimulated mouse vas deferens assays Org 27569 reduced WIN55212-induced contractions exhibiting a pEC50 of 8 24 0 12 and a maximal response (Emax) of approximately 45 4% Binding studies suggest its interaction at a putative allosteric site on CB1 receptors reflected by parameters such as a pKB of 5 67 0 23 and a Log of 1 14 0 17 Org 27569 serves as a tool compound for studying CB1 receptor allosteric modulation
Apexbio Technology LLC GMX1778 (CHS828) 200484-11-3 10mM (in 1mL DMSO)
GMX1778 (CHS828 CAS 200484-11-3) is a small-molecule inhibitor targeting nicotinamide phosphoribosyltransferase (NAMPT) an enzyme crucial for NAD biosynthesis with a reported Kd value of 120 nM NAD functions as a cofactor essential for enzymatic oxidation-reduction processes and diverse cellular events including metabolism genomic integrity calcium signaling aging and apoptosis In cultured IM-9 cells exposure to GMX1778 substantially decreases NAD and NM levels in a time-dependent manner GMX1778 displays anti-tumor activity preferentially in NAPRT1-deficient cancer models highlighting its potential utility for investigating metabolic vulnerabilities and targeted cancer therapies
Apexbio Technology LLC Dronedarone 141626-36-0 10mM (in 1mL DMSO)
Dronedarone (CAS 141626-36-0) is a benzofuran derivative structurally related to amiodarone designed to manage cardiac arrhythmias It exerts its pharmacological effects primarily through multichannel blockade inhibiting sodium potassium and calcium ion currents and demonstrating anti-adrenergic properties By prolonging action potential duration and refractory periods dronedarone contributes to the stabilization and restoration of regular cardiac rhythm In biomedical research contexts dronedarone serves as a valuable tool for exploring arrhythmogenesis mechanisms and developing therapeutic approaches for atrial fibrillation and atrial flutter
Apexbio Technology LLC TG003 300801-52-9 10mM (in 1mL DMSO)
TG003 (CAS 300801-52-9) is a selective inhibitor targeting the Cdc2-like kinase (Clk) family and casein kinase 1 (CK1) Specifically it demonstrates notable potency against mClk1 mClk2 and mClk4 with IC50 values of approximately 20 nM 200 nM and 15 nM respectively TG003 competitively binds with ATP at Clk1 modulating Clk-mediated phosphorylation of serine/arginine-rich (SR) proteins involved in alternative mRNA splicing Studies using HeLa cellular extracts and animal models have shown that TG003 alters splice site selection and pre-mRNA processing suggesting potential utility for investigating RNA splicing regulatory mechanisms
Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders
Apexbio Technology LLC LY2835219 1231930-82-7 10mM (in 1mL DMSO)
LY2835219 (CAS 1231930-82-7) is a selective orally bioavailable inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) It targets CDK4 and CDK6 with reported IC50 values of 2 nM and 10 nM respectively thereby reducing phosphorylation of the retinoblastoma protein (Rb) This mechanism leads to cell-cycle arrest during the G1 phase and subsequent inhibition of tumor cell proliferation LY2835219 demonstrates the capacity to cross the blood-brain barrier indicating its potential utility in research involving primary or metastatic intracranial tumors
Apexbio Technology LLC RG 108 48208-26-0 10mM (in 1mL DMSO)
RG 108 (CAS 48208-26-0) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) It acts by directly blocking DNMT activity without forming covalent enzyme-adducts leading to DNA demethylation and consequent reactivation of epigenetically silenced tumor suppressor genes However RG 108 treatment does not affect methylation status of centromeric satellite DNA sequences In cellular models RG 108 promotes reprogramming efficiency especially enhancing induction of pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs) It is useful for studying epigenetic gene regulation tumor suppression pathways and cellular reprogramming mechanisms
Medchemexpress LLC Dm4 Solution 10Mm1Ml In Dmso | HY-12454-10MM1ML/DMSO SOL
Dm4 Solution 10Mm1Ml In Dmso
