Dimethyl Sulfoxide
Medchemexpress LLC 10 MM 1 ML IN DMSO READY 1MM
10 mM * 1 mL in DMSO ready for reconstitution, 1Mm, 2883540-92-7
Medchemexpress LLC Afatinib 10Mm 1Ml/Dmso Reconst | HY-10261-10MM 1ML RECONS
Afatinib 10Mm 1Ml/Dmso Reconst
Apexbio Technology LLC Celastrol 34157-83-0 10mM (in 1mL DMSO)
Celastrol (CAS 34157-83-0) is a triterpene compound isolated from the Chinese medicinal herb Thunder of God Vine It functions as a proteasome inhibitor targeting the proteolytic activities within the 20S and 26S proteasome complexes leading to intracellular accumulation of ubiquitinated substrates including I B- Bax and p27 thereby inducing apoptosis in cancer cell lines such as human prostate cancer (PC-3 and LNCaP) Celastrol also inhibits NF- B signaling decreasing LPS-induced production of inflammatory cytokines (TNF- and IL-1 ) in human PBMCs and augmenting TNF-mediated apoptosis in KBM-5 cells Its anti-inflammatory and pro-apoptotic properties make celastrol relevant in cancer and inflammation research
Apexbio Technology LLC Macitentan 441798-33-0 10mM (in 1mL DMSO)
Macitentan (CAS 441798-33-0) is a small molecule endothelin receptor antagonist acting as a dual inhibitor of ETA and ETB receptors Experimental data using recombinant ETA-expressing CHO cells show that macitentan exhibits potent inhibition of ET-1 ligand binding with an IC50 of approximately 0 5 nM whereas its inhibitory effect on ETB receptors in similar CHO cell systems is weaker (IC50 391 nM) In vivo rodent studies indicate macitentan rapidly converts into ACT-132577 a circulating metabolite with extended half-life and retained dual receptor antagonism This pharmacological profile makes macitentan relevant for biomedical research on endothelin-associated vascular pathologies
Medchemexpress LLC Jq1 1Mm Dmso Reconstitution | HY-13030-10MM DMSO RECONS
Jq1 1Mm Dmso Reconstitution
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ReagentPlus(R), >=99.5% | 67-68-5 | MFCD00002089 | 10L
Dimethyl sulfoxide ReagentPlus(R), >=99.5% | Purity: >=99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 10L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 1L
Molecular Formula: (CH3)2SO, Molecular Weight: 78.13, Beilstein Registry Number: 506008, Assay: ≥99.5% (GC)
Apexbio Technology LLC 4μ8C 14003-96-4 10mM (in 1mL DMSO)
4 8C (CAS 14003-96-4) is a small molecule inhibitor targeting the RNase activity of inositol-requiring enzyme 1 alpha (IRE1 ) an important transmembrane serine/threonine kinase involved in the unfolded protein response (UPR) By selectively blocking IRE1-mediated RNase function 4 8C inhibits downstream UPR gene activation in cell lines exposed to hypoxia or endoplasmic reticulum (ER) stressors including HCT116 colon carcinoma and KP4 pancreatic cancer cells without affecting proliferation or clonogenic survival under these conditions Due to its selective action 4 8C serves as a valuable tool in research investigating ER stress pathways and their roles in cellular adaptation and disease pathology
Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 10mM (in 1mL DMSO)
Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research