Dimethyl Sulfoxide
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 | C5H9NO5S | 25 MG
Carbocysteine sulfoxide is a small-molecule drug intermediate and a reported impurity of carbocisteine supplied for research and analytical use. It is intended for impurity profiling, method development, and related analytical applications. The compound is identified by CAS number 5439-87-2 and has formula C5H9NO5S and a molecular weight of 195.19 g/mol. Storage and handling recommendations are provided in the product certificate of analysis.
Medchemexpress LLC Ro4929097 10 Mm / 1 Ml In Dmso | HY-11102-10MM/1ML IN DMSO
Ro4929097 10 Mm / 1 Ml In Dmso
Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 10mM (in 1mL DMSO)
Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
Apexbio Technology LLC Meropenem 96036-03-2 10mM (in 1mL DMSO)
Meropenem is a broad-spectrum -lactam antibiotic within the carbapenem subclass characterized by bactericidal activity against both gram-positive and gram-negative organisms It primarily acts by binding to penicillin-binding proteins (PBPs) mainly PBP2 of Escherichia coli and Pseudomonas aeruginosa and PBP1 of Staphylococcus aureus thus disrupting cell wall synthesis and bacterial growth In vitro studies indicate Meropenem inhibition is effective at MIC 4 mg/L (susceptible strains) intermediate at 8 mg/L and resistant at 16 mg/L Meropenem demonstrates greater potency against gram-negative bacteria compared to Imipenem with typical IC50 values around 0 25 mg/L for anaerobic strains It is typically used in microbiological research to investigate antibiotic susceptibility bacterial resistance mechanisms and interactions with drug metabolism
Apexbio Technology LLC Etodolac 41340-25-4 10mM (in 1mL DMSO)
Etodolac (CAS 41340-25-4) is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs) It exhibits inhibitory activity against COX-2 with an IC50 of 53 5 nM Etodolac is commonly utilized for research involving inflammatory conditions such as osteoarthritis and rheumatoid arthritis In isolated rabbit articular chondrocytes stimulated with TNF Etodolac prevented apoptotic cell shrinkage and suppressed caspase-3/7 activation Conversely in human malignant rhabdoid tumor cells (FRTK-1) Etodolac induced apoptosis in a dose-dependent manner increasing activities of caspase-3 -8 and -9
Apexbio Technology LLC Busulfan 55-98-1 10mM (in 1mL DMSO)
Busulfan is a DNA alkylating agent widely used in biomedical research as an anticancer compound It functions by forming cross-links on guanine bases within DNA leading to DNA damage and subsequent inhibition of cell growth and proliferation In vitro studies reveal that exposure to busulfan (IC50 range approximately 7 5 120 M) promotes cellular senescence in normal human fibroblast cell lines mediated through increased reactive oxygen species (ROS) and sustained activation of MAPK signaling pathways Additionally busulfan is utilized in fertility and reproductive biology research due to its ability to induce apoptosis in male germ cells reducing germ cell populations in experimental mouse models
Apexbio Technology LLC SLx-2119 911417-87-3 10mM (in 1mL DMSO)
SLx-2119 (CAS 911417-87-3) also known as KD-025 is a selective inhibitor targeting Rho-associated protein kinase 2 (ROCK2) exhibiting an IC50 of approximately 105 nM ROCK2 is a serine/threonine kinase central to cytoskeletal modulation and cellular signaling particularly expressed within neuronal and vascular cells SLx-2119 reduces connective tissue growth factor (CTGF) mRNA expression selectively in human intestinal smooth muscle cells isolated from radiation-induced fibrosis tissue (RE-SMC) whereas normal smooth muscle cells remain unaffected Additionally in a murine model of focal cerebral ischemia SLx-2119 treatment yields a dose-dependent decrease in infarct size across aged and diabetic models highlighting its research applicability in ischemic stroke and fibrotic disorders
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 10mM (in 1mL DMSO)
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Apexbio Technology LLC PLX-4720 918505-84-7 10mM (in 1mL DMSO)
PLX-4720 (CAS 918505-84-7) is a selective inhibitor of the oncogenic kinase B-RafV600E a frequently observed activating mutation in cancer Structurally derived from a 7-azaindole scaffold PLX-4720 inhibits B-RafV600E with an IC50 of 13 nM exhibiting marked selectivity in comparison to wild-type B-Raf (IC50 160 nM) and other kinases such as FRK CSK SRC FAK FGFR and Aurora A (IC50 1000 nM) PLX-4720 decreases ERK phosphorylation in B-RafV600E-containing cells induces growth arrest and apoptosis in B-RafV600E melanoma lines and delays tumor progression in xenograft models harboring this mutation It represents a valuable tool in cancer research targeting B-Raf signaling pathways
Apexbio Technology LLC Epoxomicin 134381-21-8 10mM (in 1mL DMSO)
Epoxomicin (CAS 134381-21-8) is a naturally occurring proteasome inhibitor initially isolated from actinomycete cultures It acts primarily by forming covalent bonds through its -epoxyketone moiety with catalytic residues of the proteasome resulting in potent inhibition of the chymotrypsin-like (CTRL) activity of the 20S proteasome subunit Epoxomicin also inhibits proteasomal trypsin-like and peptidyl-glutamyl peptide hydrolysis activities albeit at significantly lower rates It exhibits anti-inflammatory and antitumor activities and is employed experimentally to study ubiquitin-proteasome-mediated cellular pathways bone formation regulation and Parkinson s disease model generation
Apexbio Technology LLC Linifanib (ABT-869) 796967-16-3 10mM (in 1mL DMSO)
Linifanib (ABT-869 CAS 796967-16-3) is an ATP-competitive inhibitor of receptor tyrosine kinases targeting platelet-derived growth factor (PDGF) and vascular endothelial growth factor receptors (VEGFRs) as well as FMS-like tyrosine kinase 3 (FLT3) including its activating internal tandem duplication (ITD) mutations Linifanib selectively reduces cell growth in FLT3 ITD-expressing cell lines such as Ba/F3 FLT3 ITD cells inhibits phosphorylation of FLT3 and Akt and induces apoptosis preferentially in ITD mutant cells In vivo experiments with ITD-expressing leukemia xenografts show reduced leukemia progression and prolonged survival in mice treated orally with linifanib This compound is widely used in preclinical research for acute myeloid leukemia studies
Apexbio Technology LLC AVL-292 1202757-89-8 10mM (in 1mL DMSO)
AVL-292 (CAS 1202757-89-8) also known as CC-292 is an orally bioavailable irreversible small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a member of the Tec kinase family crucial for B-cell receptor (BCR) signaling pathways AVL-292 covalently binds the cysteine residue (Cys481) within BTK suppressing its autophosphorylation and downstream signaling Reported IC50 and EC50 values in biochemical and cellular assays are 0 5 nM and 8 nM respectively AVL-292 has shown efficacy in preclinical models such as collagen-induced arthritis (CIA) mice and demonstrates therapeutic potential in clinical studies involving B-cell malignancies including CLL B-NHL and WM
Apexbio Technology LLC Calpain Inhibitor II, ALLM 136632-32-1 10mM (in 1mL DMSO)
Calpain inhibitor II (also termed ALLM or CPI-2) is a membrane-permeable inhibitor targeting calpain I calpain II as well as cathepsin L and B Calpain inhibition by this compound can activate apoptosis via caspase-mediated pathways Studies conducted in acute lymphoblastic leukemia (ALL) cell lines (such as ALL-1 RS4 11 JURKAT) and non-Hodgkin s lymphoma (NHL) cells (including RAMOS DAUDI) revealed apoptosis induction at concentrations of 50 100 M Additionally apoptosis triggered by calpain inhibitor II appears independent of tyrosine kinases BTK and LYN Unlike calpain inhibitor I calpain inhibitor II does not influence NF- B signaling nor sensitize tumor cells to TRAIL-induced apoptosis This inhibitor is widely employed in apoptosis-related research and studies exploring calpain-associated cellular pathways
Apexbio Technology LLC Mupirocin 12650-69-0 10mM (in 1mL DMSO)
Mupirocin is an antibiotic targeting bacterial protein synthesis by inhibition of isoleucyl-tRNA synthetase Structurally analogous to isoleucine it binds the enzyme s active site blocking formation of isoleucyl-tRNA thus arresting bacterial protein production with reported MIC values around 0 05 g/ml for Staphylococcus aureus Primarily active against Gram-positive strains notably methicillin-resistant Staphylococcus aureus (MRSA) it is widely applied in biomedical research focused on antimicrobial resistance soft tissue infections biofilm studies and nasal colonization control strategies