Dimethyl Sulfoxide
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC (+)-MK 801(Synonyms: Dizocilpine, Dizocilpine maleate, MK-801, (+)-MK-801, (+)-Dizocilpine), 10mM (in 1mL DMSO), CAS: 70449-94-4.
( )-MK 801 (CAS 70449-94-4) is a potent selective and non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor displaying a Ki of approximately 30 5 nM This small molecule readily crosses the blood-brain barrier and interacts reversibly with specific binding sites on cortical membranes predominantly localized within the hippocampus In vitro assays utilizing rat cortical slice preparations indicate that ( )-MK 801 robustly inhibits NMDA-induced depolarization events and suppresses epileptiform activity mediated by neurotoxic agents Due to these pharmacological properties ( )-MK 801 is utilized experimentally in neuroscience research to study NMDA receptor-mediated events neurotoxicity convulsions and excitatory neurotransmission pathways
Apexbio Technology LLC GYY 4137 morpholine salt(Synonyms: GYY4137, Morpholin-4-ium 4-methoxyphenyl(morpholino)phosphinodithioate, GYY-4137), 10mM (in 1mL DMSO), CAS: 106740-09-4.
GYY 4137 morpholine salt (CAS 106740-09-4) is a slow-releasing hydrogen sulfide (H S) donor that exerts biological activity by modulating signaling pathways involved in vasodilation and blood pressure regulation In experimental studies this compound demonstrates the capacity to suppress cellular proliferation induce apoptosis and arrest cell cycle progression Due to these properties GYY 4137 morpholine salt is widely utilized in research investigating hypertension inflammation and cancer biology
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 4 x 2 mL
Dimethyl sulfoxide | Purity: ≥99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4 x 2 mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitable for HPLC, >=99.7% | 67-68-5 | MFCD00002089 | 4X2L
Dimethyl sulfoxide suitable for HPLC, >=99.7% | Purity: >=99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4X2L
Medchemexpress LLC IDASANUTLIN MM 1 ML IN DMSO
Idasanutlin mM * 1 mL in DMSO ready for reconstitution
Electron Microscopy Sciences (DMSO), Dimethyl Sulfoxide, Reagent A.C.S. 450 ML
(2-Hydroxyethyl methacrylate monomer, inhibited;HEMA)
CAS #67-68-5 (CH₃)₂SO F.W. 78.13
Apexbio Technology LLC Avasimibe 166518-60-1 10mM (in 1mL DMSO)
Avasimibe (CAS 166518-60-1) is an orally bioavailable inhibitor of acyl-coenzyme A cholesterol acyltransferase (ACAT) an enzyme involved in cholesterol esterification It exhibits potent inhibition with an IC50 of approximately 60 nM In cell-based studies avasimibe reduces intracellular cholesterol esters in a dose-dependent manner without elevating free cholesterol levels suggesting an advantageous safety profile Additionally avasimibe reduces synthesis and secretion of Apo B 100 a constituent of very low-density lipoprotein (VLDL) in HepG2 cells and increases bile acid synthesis in rat hepatocytes Beyond dyslipidemic modulation and anti-atherogenic activities it influences amyloid precursor protein (APP) trafficking reducing its maturation and subsequent amyloid-beta (A ) peptide generation providing avenues for Alzheimer s disease research
Apexbio Technology LLC NU7441 (KU-57788) 503468-95-9 10mM (in 1mL DMSO)
NU7441 (KU-57788 CAS 503468-95-9) is a selective inhibitor targeting DNA-dependent protein kinase (DNA-PK) via competition with ATP exhibiting an IC50 of approximately 13 nM and a Ki of 0 65 nM It demonstrates high specificity showing minimal inhibition of related kinases ATM and ATR at concentrations up to 100 M and substantially weaker activity towards mTOR and PI3K (IC50 values of 1 7 and 5 M respectively) NU7441 sensitizes HeLa cells to etoposide enhancing cytotoxicity and augments tumor growth delay when co-administered in SW620 xenograft mouse models The molecule serves as a tool compound in DNA repair and oncology research
Apexbio Technology LLC Gefitinib (ZD1839) 184475-35-2 10mM (in 1mL DMSO)
Gefitinib (ZD1839 CAS 184475-35-2) is an orally bioavailable small-molecule inhibitor that specifically targets epidermal growth factor receptor (EGFR) tyrosine kinase Acting competitively by occupying the ATP-binding domain of EGFR gefitinib blocks ATP interaction and thereby inhibits EGFR autophosphorylation and downstream signaling In biochemical assays gefitinib demonstrates IC50 values of 0 033 M and 0 027 M against EGFR tyrosine kinase activity in A431 membrane preparations and baculovirus lysates respectively Consequently gefitinib suppresses tumor proliferation induces apoptosis and exhibits activity in models of various solid tumors including lung colorectal breast head and neck prostate and ovarian cancers
Apexbio Technology LLC CFTRinh-172 307510-92-5 10mM (in 1mL DMSO)
CFTRinh-172 (CAS 307510-92-5) is a small molecule inhibitor selectively targeting the cystic fibrosis transmembrane conductance regulator (CFTR) a cAMP-activated chloride channel involved in epithelial fluid transport in organs such as lung intestine and pancreas It acts by reversibly and voltage-independently inhibiting CFTR currents with a Ki in the range of 0 3 5 M Experimental studies demonstrate CFTRinh-172 rapidly blocks CFTR-mediated short-circuit currents while exhibiting minimal cross-reactivity towards other channels or transporters In animal models CFTRinh-172 reduces cholera toxin-induced intestinal fluid secretion suggesting potential applications in developing cystic fibrosis models and investigating secretory diarrheal diseases
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Apexbio Technology LLC CP-724714 537705-08-1 10mM (in 1mL DMSO)
CP-724714 (CAS 537705-08-1) is a small molecule inhibitor selectively targeting erbB2 (Her2) and EGFR kinases with notable potency against erbB2 kinase (IC50 10 3 nM) and considerably lower activity toward EGFR kinase (IC50 6 400 2 100 nM) In cellular assays CP-724714 induces G1 cell-cycle arrest and decreases erbB2 phosphorylation in Her2-overexpressing BT-474 breast cancer cells In animal xenograft models (BT-474 MDA-MB-453) it reduces erbB2 receptor phosphorylation and downstream signaling resulting in tumor growth inhibition and apoptosis induction CP-724714 advanced into phase I clinical trials for Her2-driven breast cancer research