Tetrahydrofuran
Medchemexpress LLC AST5902 trimesylate | 2929417-90-1 | 98.8% | 842.88 | 50 MG
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. It exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
- Principal metabolite of Alflutinib
- Exerts antineoplastic activity
- EGFR inhibitor
- Yellow to orange solid
- Store at 4°C, sealed, away from moisture and light
- In solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC N-vanillyldecanamide | 31078-36-1 | MFCD01233545 | 99.9% | 307.43 g·mol⁻¹ | C18H29NO3 | 10 MG
N-Vanillyldecanamide is a capsaicinoid research chemical (CAS 31078-36-1) isolated from the fruits of Capsicum annuum. It has been reported to reduce the radical length of Lactuca sativa seedlings in a dose-dependent manner. The compound is supplied for laboratory research use with supporting documentation for handling and analysis.
- High purity (99.86%) suitable for analytical and biological studies.
- Molecular formula C18H29NO3 and molecular weight 307.43 g·mol⁻¹.
- Supplied in small laboratory quantities, including a 10 mg pack size.
- Available as a solid and as 10 mM solutions in DMSO for convenience.
- Storage: keep at 4°C and protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
- Typical applications include capsaicinoid activity studies, plant physiology research, and structure-activity investigations.
- Product documentation includes datasheet, COA, and SDS for quality and safety reference.
Medchemexpress LLC Acrylodan | 86636-92-2 | 95.1% | 225.29 g/mol | C15H15NO | 5 MG
Acrylodan is a thiol-reactive, environment-sensitive fluorescent dye that covalently labels cysteine residues and reports on local dipolarity and conformational dynamics within binding pockets such as Cys34.
- Reacts with thiols to form a covalent fluorescent adduct.
- Sensitive to local dipolarity and protein dynamics.
- Soluble in DMSO at approximately 50 mg/mL; ultrasonic agitation may be required.
- Purity approximately 95.1%; molecular weight 225.29 g/mol.
- Store protected from light; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC CIL62 | 117593-36-9 | 97.0% | 382.45 | 50 MG
CIL62 is a caspase-3/7-independent cell death inducer that operates via Necrostatin-1 dependent mechanisms. It exhibits antiproliferative activity against human COLO205, IMR32, and K562 cells.
- Caspase-3/7-independent cell death inducer
- Necrostatin-1 dependent mechanism of action
- Antiproliferative activity against COLO205, IMR32, and K562 cells
Medchemexpress LLC AZ12601011 | 2748337-86-0 | 99.8% | 100 MG
AZ12601011 is an orally active, selective TGFBR1 (ALK5) kinase inhibitor intended for laboratory research. It inhibits SMAD2 phosphorylation (IC50 = 18 nM; Kd = 2.9 nM), has demonstrated antitumor activity in preclinical models, and is provided with high analytical purity for biochemical assays.
- Selective TGFBR1 inhibition with low-nanomolar potency.
- Inhibits SMAD2 phosphorylation in signaling assays.
- High analytical purity suitable for biochemical studies.
- Supplied as a 100 mg solid for convenient dosing.
- For research use only; not for human or clinical use.
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
Medchemexpress LLC Nelonicline | 1026134-63-3 | 99.8% | 313.42 g/mol | C17H19N3OS | 10 MG
Nelonicline is an orally active, selective agonist of the α7 nicotinic acetylcholine receptor supplied as a research reagent for preclinical and in vitro studies. It has molecular formula C17H19N3OS and molecular weight 313.42 g/mol. For research use only; not for clinical or diagnostic applications.
- Selective α7 nicotinic acetylcholine receptor agonist suitable for receptor pharmacology studies.
- Orally active small molecule compatible with in vivo and in vitro experiments.
- Available as a 10 MG solid and as a 10 mM solution in DMSO for assay use.
- High-purity research compound appropriate for preclinical studies.
- Supplied for research use only, not intended for therapeutic use.
Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.11% | 534.61 | 50 MG
Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for research on brain ischemic injury.
- MMP inhibitor
- Blocks NMDA receptor-mediated excitotoxicity competitively
- Exhibits anti-oxidant activity
- Potential for research of brain ischemic injury
- Protects neuronal cells against NMDA-induced cell death
- Inhibits Ca2+ influx following activation of NMDA receptors in primary cultured neurons
- Suppresses H2O2-induced cell death and reactive oxygen species production
- Prevents ischemic neuronal death in the occlusion model of MCA in rats
- Attenuates impairment of stroke-induced motor function in rats
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.18% | 348.44 | 50 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It inhibits MRCKβ with an IC50 of 64 nM in SCC12 cells and has Ki values of 0.0136 nM for MRCKα and 0.0233 nM for MRCKβ. This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Potent and selective inhibitor of MRCKα and MRCKβ.
- Exhibits antiproliferative effects, particularly in hematologic cancer cells.
- Inhibits MLC phosphorylation and blocks motility and invasion of SCC12 squamous cell carcinoma.
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
Medchemexpress LLC Ro5-3335 | 30195-30-3 | 99.35% | 259.69 | 100 MG
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. It is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
- Exhibits antiproliferative activity against human CBF leukemia cell lines.
- Inhibits definitive hematopoiesis in zebrafish embryos.
- Modifies the conformation or increases the distance between the components of the RUNX1-CBFβ complex.
- Identified as an inhibitor of RUNX1-CBFβ function in zebrafish models.
- Rescues preleukemic phenotype in transgenic zebrafish.
- Reduces leukemia burden in a mouse leukemia model.
Medchemexpress LLC XL-784 | 1224964-36-6 | 98.25% | 548.92 | 50 MG
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor. It is a highly potent, low-molecular-weight inhibitor with limited aqueous solubility. This compound potently inhibits MMP-2, MMP-13, and ADAM10 (TNF-α-converting enzyme (TACE)) activity, with IC50 values typically in the 1-2 nM range. It also demonstrates inhibitory effects on MMP-9 and ADAM17, while exhibiting lower potency for MMP-1. Animal studies have shown that treatment with XL-784 effectively inhibits aortic dilatation.
- Selective matrix metalloproteinases (MMP) inhibitor.
- Potently inhibits MMP-2, MMP-13, and ADAM10 activity.
- Inhibitory effects on MMP-9 and ADAM17.
- Low-molecular-weight compound.
- Limited aqueous solubility.
- Effective in inhibiting aortic dilatation in animal models.
- Available in various solid forms and as a DMSO solution.
![eMolecules 1779133-13-9 | 6-OXASPIRO[2.5]OCTAN-1-AMINE HCL | AstaTech | MFCD26097093 | 163.650 | C7H14ClNO | 95.000 | Cl.NC1CC11CCOCC1 | 1g | 534090821](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502181349.JPG-250.jpg)
eMolecules 1779133-13-9 | 6-OXASPIRO[2.5]OCTAN-1-AMINE HCL | AstaTech | MFCD26097093 | 163.650 | C7H14ClNO | 95.000 | Cl.NC1CC11CCOCC1 | 1g | 534090821
6-OXASPIRO[2.5]OCTAN-1-AMINE HCL | AstaTech | 1779133-13-9 | MFCD26097093 | 163.650 | C7H14ClNO | 95.000 | Cl.NC1CC11CCOCC1 | 1g | 534090821
Ambeed 1-OXASPIRO(4.5)DECAN-2-O,250MG
1-Oxaspiro[4.5]decan-2-one | CAS No. 699-61-6 | MDL No.: MFCD00459846 | Formula: C9H14O2