Tetrahydrofuran
Medchemexpress LLC Phosphatidylinositols, soya, sodium salts | 383907-36-6 | MFCD00145109 | 99.3% | 857.0352 | C43H78NaO13P | 5 MG
Phosphatidylinositols, soya, sodium salts is a soy-derived mixture of phosphatidylinositol lipids provided as the sodium salt for research use. Phosphoinositides participate in membrane trafficking and lipid signaling by recruiting or activating effector proteins; this material is supplied as a solid for biochemical and lipid biology applications.
- High reported purity (99.3%).
- Supplied as a solid, white to off-white.
- Available in small vial sizes suitable for assay work.
- Suitable for studies of vesicular transport, membrane fusion, and cytoskeleton dynamics.
- Store sealed at -20°C; in solvent, -80°C recommended for long-term storage.
Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.11% | 534.61 | 50 MG
Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for research on brain ischemic injury.
- MMP inhibitor
- Blocks NMDA receptor-mediated excitotoxicity competitively
- Exhibits anti-oxidant activity
- Potential for research of brain ischemic injury
- Protects neuronal cells against NMDA-induced cell death
- Inhibits Ca2+ influx following activation of NMDA receptors in primary cultured neurons
- Suppresses H2O2-induced cell death and reactive oxygen species production
- Prevents ischemic neuronal death in the occlusion model of MCA in rats
- Attenuates impairment of stroke-induced motor function in rats
Medchemexpress LLC Tenuifoliside B | 139726-36-6 | 5 MG
Tenuifoliside B is a component isolated from Polygalae Radix. It inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. This compound demonstrates potential cognitive improvement and cerebral protective effects, and it has the potential to be an anti-AD lead compound.
- Demonstrates potential cognitive improvement
- Demonstrates cerebral protective effects
- Has the potential to be an anti-AD lead compound
Medchemexpress LLC XL-784 | 1224964-36-6 | 98.25% | 548.92 | 50 MG
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor. It is a highly potent, low-molecular-weight inhibitor with limited aqueous solubility. This compound potently inhibits MMP-2, MMP-13, and ADAM10 (TNF-α-converting enzyme (TACE)) activity, with IC50 values typically in the 1-2 nM range. It also demonstrates inhibitory effects on MMP-9 and ADAM17, while exhibiting lower potency for MMP-1. Animal studies have shown that treatment with XL-784 effectively inhibits aortic dilatation.
- Selective matrix metalloproteinases (MMP) inhibitor.
- Potently inhibits MMP-2, MMP-13, and ADAM10 activity.
- Inhibitory effects on MMP-9 and ADAM17.
- Low-molecular-weight compound.
- Limited aqueous solubility.
- Effective in inhibiting aortic dilatation in animal models.
- Available in various solid forms and as a DMSO solution.
Medchemexpress LLC VPC-70619 | 2361742-30-3 | 99.93% | C16H8ClF3N4O | 100 MG
VPC-70619 is a potent N-Myc inhibitor that blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box and shows strong inhibitory activity against N-Myc-dependent cell lines. It can partially reverse paclitaxel resistance in cells by reducing MYCN expression and can be used for cancer research, including neuroblastoma and thyroid cancer.
- Potent N-Myc inhibitor
- Blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box
- Shows strong inhibitory activity against N-Myc-dependent cell lines
- Partially reverses paclitaxel resistance by reducing MYCN expression
- Can be used for cancer research, including neuroblastoma and thyroid cancer
- Demonstrates high inhibition rates in certain cell types
- Highly stable in liver microsomes
- Regulates MYCN signaling pathway
- Inhibits proliferation, migration, and aggressiveness of cancer cells
Medchemexpress LLC 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide | 2871872-79-4 | 99.9% | C18H26N4O3S | 50 MG
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.
- Potent bone anabolic agent
- Orally active
- Inhibits CDK8
- For research use only
Medchemexpress LLC Zectivimod | 1623066-63-6 | 99.4% | 528.5 g/mol | C28H31Cl2N3O3 | 5 MG
Zectivimod is a small-molecule sphingosine-1-phosphate receptor (S1P1) agonist used in research on immune modulation. It has been investigated as an orally available S1P1 modulator and is employed in preclinical and clinical research focused on autoimmune and chronic inflammatory diseases. The compound is supplied for laboratory research use only.
- Selective S1P1 receptor agonist for immune modulation studies.
- Investigated as an orally available S1P1 modulator.
- Useful for research into autoimmune and chronic inflammatory diseases.
- High chemical purity (>99%).
- Supplied in small laboratory quantities for experimental use.
- Not for human or veterinary use; for research only.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran contains 2200L
Tetrahydrofuran (THf) is a widely used organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. The effect of THf on the biological systems has been studied.
Medchemexpress LLC Sodium citrate dihydrate | 6132-04-3 | 98.0% | 500 MG
Sodium citrate dihydrate is a natural product with oral activity found in citrus fruits. It can inhibit the proliferation of tumor cells and induce apoptosis. It also exhibits antibacterial, anti-tumor, and antioxidant activities, and can be used as a cosolvent or buffer. This compound meets USP testing specifications and acts as an anticoagulant.
- Inhibits proliferation of tumor cells and induces apoptosis.
- Exhibits antibacterial, anti-tumor, and antioxidant activities.
- Can be used as a cosolvent or buffer.
- Acts as an anticoagulant by chelating calcium ions.
- Utilized for preparing buffers (e.g., DNA extraction, protein crystallization) and pH adjustment.
- Serves as a chelating agent to remove metal ion interference.
eMolecules Ambeed / 4-(Dimethylamino)picolinic acid / 100mg / 569096432 / A543061 / / 890092-04-3 / MFCD04971955 / 166.180 / C8H10N2O2
Ambeed / 4-(Dimethylamino)picolinic acid / 100mg / 569096432 / A543061 / / 890092-04-3 / MFCD04971955 / 166.180 / C8H10N2O2
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran anhydrous1L
Tetrahydrofuran (THf) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THf forms double hydrate with hydrogen sulfide crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.
Medchemexpress LLC CSF1R-IN-1 | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 100 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with subnanomolar enzymatic potency (IC50 = 0.5 nM). It has demonstrated good intestinal permeability and favorable oral pharmacokinetics in mice, supporting its use in preclinical in vivo pharmacology studies related to tumor-associated macrophage biology, cancer, and inflammation research.
- Potent CSF1R inhibition (IC50 = 0.5 nM).
- Suitable for preclinical in vivo pharmacology studies.
- Demonstrates good intestinal permeability in Caco-2 assays.
- Favorable oral pharmacokinetic profile in mice.
- Available in solid and DMSO solution formats for dosing flexibility.
- High reported purity for research use.
eMolecules Tetrahydrofuran ACS | Oakwood Chemicals | 109-99-9 | MFCD00005356 | 72.107 | C4H8O | 99.000 | C1CCOC1 | 1l | 480133467
Tetrahydrofuran ACS | Oakwood Chemicals | 109-99-9 | MFCD00005356 | 72.107 | C4H8O | 99.000 | C1CCOC1 | 1l | 480133467
Medchemexpress LLC Ambroxide | 6790-58-5 | 236.39 | 50 MG
Ambroxide is a naturally occurring terpenoid and a key constituent of ambergris. It is used in the manufacture of high-end perfumes to improve aroma quality and fragrance lasting time.
- Molecular weight: 236.39
- Formula: C16H28O
- CAS No.: 6790-58-5
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, other terpenoids
- Initial source: Plants (other families), animals (Physeter catodon L.)
- Purity: 98.0%
- Solubility in vitro: Soluble in DMSO (25 mg/mL)
Medchemexpress LLC SU5214 | 186611-04-1 | 98.0% | 251.28 | 5 MG
SU5214 is a potent VEGFR2 inhibitor. It has been extracted from patent US5834504A and exhibits IC50s of 14.8 μM for FLK-1 and 36.7 μM for EGFR.
- Potent VEGFR2 inhibitor.
- Targets VEGFR.
- Acts on the Protein Tyrosine Kinase/RTK pathway.
- Soluble in DMSO at 100 mg/mL.
- Suitable for research purposes.