Tetrahydrofuran
Medchemexpress LLC Linzagolix | 935283-04-8 | 99.7% | 508.42 | 50 MG
Linzagolix is a potent, non-peptide, and orally active GnRH antagonist. It can be used for uterine fibroids, endometriosis, and adenomyosis research. For research use only.
- Potent, non-peptide, and orally active GnRH antagonist
- Used for uterine fibroids, endometriosis, and adenomyosis research
Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.11% | 534.61 | 50 MG
Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for research on brain ischemic injury.
- MMP inhibitor
- Blocks NMDA receptor-mediated excitotoxicity competitively
- Exhibits anti-oxidant activity
- Potential for research of brain ischemic injury
- Protects neuronal cells against NMDA-induced cell death
- Inhibits Ca2+ influx following activation of NMDA receptors in primary cultured neurons
- Suppresses H2O2-induced cell death and reactive oxygen species production
- Prevents ischemic neuronal death in the occlusion model of MCA in rats
- Attenuates impairment of stroke-induced motor function in rats
Medchemexpress LLC Tabersonine | 4429-63-4 | MFCD28140545 | 336.43 | 50 MG
Tabersonine | 4429-63-4 | MFCD28140545 | 336.43 | 50 MG
Medchemexpress LLC Rhamnocitrin | 569-92-6 | 300.26 | 5 MG
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3, and MAPK pathways. It selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons by regulating miR-185, STIM-1, NFATc3, and ERK/p38 MAPK pathways. It can be used in the study of endothelial-related inflammatory diseases and neuroprotection.
- Functions as an anti-inflammatory and antioxidant agent.
- Targets STIM-1, NFATc3, and MAPK pathways.
- Inhibits oxidative stress and inflammatory responses.
- Useful for studying endothelial-related inflammatory diseases.
- Useful for neuroprotection research.
Medchemexpress LLC CIL62 | 117593-36-9 | 97.0% | 382.45 | 100 MG
CIL62 is a caspase-3/7-independent cell death inducer. Its mechanism of action is Necrostatin-1 dependent cell death.
- COLO 205: IC50 28 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- IMR-32: IC50 41 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- K562: IC50 36 μM (Compound: 3f) for antiproliferative activity after 24 hrs by MTT assay.
- Necrostatin-1 suppresses CIL62 at 19 μM (5 μg/mL).
Medchemexpress LLC Deacylmetaplexigenin | 3513-04-0 | 1 MG
Deacylmetaplexigenin is a natural product and steroid, specifically a pregnane glycoside. This compound has been isolated from plants such as Asclepias incarnata, Cynanchum viminale, and Cynanchum rostellatum.
- Molecular weight: 380.5 g/mol
- XLogP3-AA: -0.4
- Hydrogen bond donors: 5
- Hydrogen bond acceptors: 6
- Rotatable bond: 1
- Topological polar surface area: 118 Ų
Medchemexpress LLC Sodium citrate dihydrate | 6132-04-3 | 98.0% | 500 MG
Sodium citrate dihydrate is a natural product with oral activity found in citrus fruits. It can inhibit the proliferation of tumor cells and induce apoptosis. It also exhibits antibacterial, anti-tumor, and antioxidant activities, and can be used as a cosolvent or buffer. This compound meets USP testing specifications and acts as an anticoagulant.
- Inhibits proliferation of tumor cells and induces apoptosis.
- Exhibits antibacterial, anti-tumor, and antioxidant activities.
- Can be used as a cosolvent or buffer.
- Acts as an anticoagulant by chelating calcium ions.
- Utilized for preparing buffers (e.g., DNA extraction, protein crystallization) and pH adjustment.
- Serves as a chelating agent to remove metal ion interference.
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 50 MG
AVJ16 is an inhibitor of insulin-like growth factor 2 mRNA binding protein (IGF2BP1), which shows a strong affinity with a Kd of 1.4 μM. It acts as a cancer cell migration inhibitor by interfering with IGF2BP1's ability to bind target mRNA, thereby regulating gene expression and translation.
- Specifically targets IGF2BP1 with a Kd of 1.4 μM.
- Interferes with IGF2BP1 binding to target mRNA, regulating gene expression and translation.
- Inhibits proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth, and induces apoptosis in H1299 and LKR-M-FI cells.
- Exhibits antitumor activity in xenograft mouse models.
Medchemexpress LLC Ecliptasaponin D | 206756-04-9 | MFCD30724971 | 99.3% | 634.84 | C36H58O9 | 10 MG
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba and supplied for research and analytical applications. It is reported to have anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory activities. Identifiers include CAS 206756-04-9 and molecular formula C36H58O9.
- High purity suitable for analytical and screening assays.
- Characterized molecular weight and formula for reproducibility.
- Supplied in small milligram quantities for compound screening and method development.
- Stable when stored at -20°C and protected from light; in solvent store at -80°C for long-term storage.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC PD-1/PD-L1-IN-23 | 2597056-04-5 | 99.9% | C32H30BrCl2N3O6 | 50 MG
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. It is an ester proagent of L7, a benzo[c]oxadiazole derivative biologically evaluated as an inhibitor of PD-L1. It has shown significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice.
- Potent and orally active inhibitor of PD-1/PD-L1
- Ester proagent of L7, a benzo[c]oxadiazole derivative
- Displays significant antitumor effects in tumor models
- For research use only
Medchemexpress LLC L-Alanine, N-phosphono-, P→6-ester with 2-C-(4-aminopyrrolo[2,1-f]triazin-7-yl)... | 1911579-04-8 | 97.86% | 442.32 | 1 MG
GS-704277 is an alanine metabolite of Remdesivir. It is further hydrolyzed to GA-441524, a compound with antiviral activity. Remdesivir, a nucleoside analogue, is effective against SARS-CoV-2 (COVID-19) infection.
- Alanine metabolite of Remdesivir
- Further metabolized to GA-441524, which exhibits antiviral activity
- Related to Remdesivir, a nucleoside analogue effective against SARS-CoV-2 (COVID-19) infection
- Functions as a drug metabolite
- Involves the metabolic enzyme/protease pathway
Medchemexpress LLC L-745870 hydrochloride | 1173023-36-3 | 99.91% | C18H20Cl2N4 | 50 MG
L-745870 hydrochloride is a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. It demonstrates weaker affinity for D2 and D3 receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound is valuable for research into dopamine receptor functions and potential therapeutic applications.
- Potent, selective, and orally active dopamine D4 receptor antagonist.
- Exhibits weaker affinity for D2 and D3 receptors.
- Good brain penetration and oral bioavailability in animal models.
- Antagonizes D4 receptor inhibition of agonist-induced [35S]-GTPγS binding.
- Blocks dopamine-induced inhibition of Ca2+ currents in GH4C1 cells.
- Inhibits D4 activation of G protein-coupled inwardly rectifying K+ channels.
Medchemexpress LLC Phosphatidylinositols, soya, sodium salts | 383907-36-6 | 99.2% | 1 MG
Phosphatidylinositols, soya, sodium salts, is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They function by recruiting and/or activating effector proteins.
- Involved in regulating various cellular functions
- Regulates vesicular budding
- Regulates membrane fusion
- Regulates cytoskeleton dynamics
Medchemexpress LLC Rhamnocitrin | 569-92-6 | MFCD00006839 | 300.26 | 1 MG
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3, and MAPK pathways. It selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons, and is applicable for studying endothelial-related inflammatory diseases and neuroprotection.
- Scavenges DPPH (IC50=28.38 mM).
- Up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE).
- Blocks NFATc3 nuclear translocation and downstream inflammatory factor expression.
- Induces heme oxygenase HO-1 expression and regulates the ERK/p38 MAPK pathway.
- Inhibits antioxidant and pro-inflammatory cytokines (e.g., IL-6, IL-8) and adhesion molecules (e.g., ICAM-1, VCAM-1).
Medchemexpress LLC Ganodermanontriol | 106518-63-2 | 472.70 | 5 MG
Ganodermanontriol is a sterol isolated from Ganoderma lucidum that induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells by expressing HO-1. It also exhibits hepatoprotective activity. It has been shown to inhibit breast cancer cell lines MCF-7 and MDA-MB-231 with IC50 values of 5.8 and 9.7 μM, respectively.
- Induces anti-inflammatory activity in damaged hepatic cells.
- Exhibits hepatoprotective activity.
- Inhibits breast cancer cell lines MCF-7 and MDA-MB-231.