Organoheterocyclic compounds
2-Chloro-3-hydroxypyridine 98.0+%, TCI America™
CAS: 6636-78-8 Molecular Formula: C5H4ClNO Molecular Weight (g/mol): 129.54 MDL Number: MFCD00006235 InChI Key: RSOPTYAZDFSMTN-UHFFFAOYSA-N Synonym: 2-chloro-3-hydroxypyridine,2-chloro-3-pyridinol,3-pyridinol, 2-chloro,unii-vy212q0s3j,2-chloro-3-hydroxy pyridine,2-chloro-3-hydroxypyridine 2-chloro-3-pyridinol,2-chlorpyridin-3-ol,pubchem2577,2-chloro-pyridin-3-ol,2-chloro-pyridine-3-ol PubChem CID: 81136 IUPAC Name: 2-chloropyridin-3-ol SMILES: OC1=CC=CN=C1Cl
5-Bromo-2-tert-butylpyrimidine 98.0+%, TCI America™
CAS: 85929-94-8 Molecular Formula: C8H11BrN2 Molecular Weight (g/mol): 215.09 MDL Number: MFCD00235040 InChI Key: FAAQGONYZKWBKC-UHFFFAOYSA-N PubChem CID: 13532898 IUPAC Name: 5-bromo-2-tert-butylpyrimidine SMILES: CC(C)(C)C1=NC=C(Br)C=N1
delta-Nonanolactone 98.0+%, TCI America™
CAS: 3301-94-8 Molecular Formula: C9H16O2 Molecular Weight (g/mol): 156.225 MDL Number: MFCD00036500 InChI Key: PXRBWNLUQYZAAX-UHFFFAOYSA-N Synonym: delta-nonalactone,5-nonanolide,6-butyltetrahydro-2h-pyran-2-one,2h-pyran-2-one, 6-butyltetrahydro,5-nonalactone,delta-nonanolactone,hydroxynonanoic acid delta-lactone,5-butyl-delta-valerolactone,delta-butyl-delta-valerolactone,delta-hydroxypelargonic acid lactone PubChem CID: 18698 IUPAC Name: 6-butyloxan-2-one SMILES: CCCCC1CCCC(=O)O1
2-Amino-4-(4-bromophenyl)thiazole 98.0+%, TCI America™
CAS: 2103-94-8 Molecular Formula: C9H7BrN2S Molecular Weight (g/mol): 255.133 MDL Number: MFCD00051953 InChI Key: ZBRNKOLWXWMLTA-UHFFFAOYSA-N Synonym: 2-amino-4-4-bromophenyl thiazole,4-4-bromophenyl-1,3-thiazol-2-amine,4-4-bromophenyl thiazol-2-amine,4-4-bromophenyl-2-thiazolamine,2-thiazolamine, 4-4-bromophenyl,4-4-bromo-phenyl-thiazol-2-ylamine,4-4-bromophenyl-1,3-thiazole-2-ylamine,2-amino-4-p-bromophenyl thiazole,2-amino-4-4-bromophenyl-1,3-thiazole,2-amino-4-4'-bromophenyl-1,3-thiazole PubChem CID: 620683 IUPAC Name: 4-(4-bromophenyl)-1,3-thiazol-2-amine SMILES: C1=CC(=CC=C1C2=CSC(=N2)N)Br
1-Methyl-3,5-dinitro-2-pyridone 98.0+%, TCI America™
CAS: 14150-94-8 Molecular Formula: C6H5N3O5 Molecular Weight (g/mol): 199.12 MDL Number: MFCD00456280 InChI Key: QARVELJVEBLWGK-UHFFFAOYSA-N Synonym: 1-Methyl-3,5-dinitropyridin-2(1H)-one PubChem CID: 3621236 IUPAC Name: 1-methyl-3,5-dinitro-1,2-dihydropyridin-2-one SMILES: CN1C=C(C=C(C1=O)[N+]([O-])=O)[N+]([O-])=O
Apexbio Technology LLC BT2 34576-94-8 10mg
BT2 (CAS 34576-94-8) is a small-molecule inhibitor of branched-chain -ketoacid dehydrogenase kinase (BCKDK) By binding to BCKDK BT2 induces conformational changes in the N-terminal domain promoting dissociation from the branched-chain -ketoacid dehydrogenase complex (BCKDC) BT2 suppresses BCKDK activity with an IC50 of 3 19 M and demonstrates selective inhibition as indicated by an IC50 of 59 M in relevant assays This compound serves as a valuable tool for investigating BCKDK-regulated metabolic pathways and the role of BCKDK in branched-chain amino acid metabolism
Apexbio Technology LLC BT2 34576-94-8 50mg
BT2 (CAS 34576-94-8) is a small-molecule inhibitor of branched-chain -ketoacid dehydrogenase kinase (BCKDK) By binding to BCKDK BT2 induces conformational changes in the N-terminal domain promoting dissociation from the branched-chain -ketoacid dehydrogenase complex (BCKDC) BT2 suppresses BCKDK activity with an IC50 of 3 19 M and demonstrates selective inhibition as indicated by an IC50 of 59 M in relevant assays This compound serves as a valuable tool for investigating BCKDK-regulated metabolic pathways and the role of BCKDK in branched-chain amino acid metabolism
Apexbio Technology LLC Desonide 638-94-8 50mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC Desonide 638-94-8 10mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC Desonide 638-94-8 100mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC IAA-94 54197-31-8 10mg
IAA-94 (CAS 54197-31-8) is a small-molecule inhibitor of epithelial chloride channels modulating cellular electrophysiological properties by disrupting chloride ion transport Experimental studies have demonstrated that IAA-94 can interfere with interactions involving the negative factor (Nef) protein during infection indicating its capacity to modulate Nef-mediated processes Due to its specificity in targeting chloride channels IAA-94 is widely utilized in investigations of ion channel-related signaling pathways in tumor cells and serves as a valuable tool in studies of cell electrophysiology and infection mechanisms
Apexbio Technology LLC Vabicaserin hydrochloride 887258-94-8 5mg
Vabicaserin hydrochloride (CAS 887258-94-8) is a selective agonist of the serotonin 5-HT2C receptor exhibiting an EC50 of 8 nM By engaging and modulating the 5-HT2C receptor-mediated signaling pathway this compound influences neurotransmitter release and neuronal excitability Vabicaserin hydrochloride has been widely utilized in preclinical models of neuropsychiatric disorders particularly in investigations pertaining to the pathophysiology and therapeutic intervention of anxiety and depression Its pharmacological profile makes it a valuable tool for studying serotonergic modulation of central nervous system function
Apexbio Technology LLC Vabicaserin hydrochloride 887258-94-8 10mg
Vabicaserin hydrochloride (CAS 887258-94-8) is a selective agonist of the serotonin 5-HT2C receptor exhibiting an EC50 of 8 nM By engaging and modulating the 5-HT2C receptor-mediated signaling pathway this compound influences neurotransmitter release and neuronal excitability Vabicaserin hydrochloride has been widely utilized in preclinical models of neuropsychiatric disorders particularly in investigations pertaining to the pathophysiology and therapeutic intervention of anxiety and depression Its pharmacological profile makes it a valuable tool for studying serotonergic modulation of central nervous system function
Apexbio Technology LLC DiSC3(5) 53213-94-8 25mg
DiSC3 5 (CAS 53213-94-8) is a fluorescent probe targeting mitochondrial membrane potential and mitochondrial NAD-dependent respiration It is designed to monitor transmembrane potential changes thereby assessing mitochondrial function DiSC3 5 exerts its biological activity primarily through specific interference with mitochondrial NAD-related respiratory pathways In cell-based studies DiSC3 5 demonstrates inhibitory activity with an IC50 value of 8 M in mitochondrial NAD-dependent respiratory systems In the presence of Na /K -ATPase inhibitor ouabain DiSC3 5 induces plasma membrane hyperpolarization in Ehrlich ascites tumor cells Based on these pharmacological properties DiSC3 5 holds research potential in mitochondrial membrane potential detection and cellular bioenergetics studies
Apexbio Technology LLC DiSC3(5) 53213-94-8 50mg
DiSC3 5 (CAS 53213-94-8) is a fluorescent probe targeting mitochondrial membrane potential and mitochondrial NAD-dependent respiration It is designed to monitor transmembrane potential changes thereby assessing mitochondrial function DiSC3 5 exerts its biological activity primarily through specific interference with mitochondrial NAD-related respiratory pathways In cell-based studies DiSC3 5 demonstrates inhibitory activity with an IC50 value of 8 M in mitochondrial NAD-dependent respiratory systems In the presence of Na /K -ATPase inhibitor ouabain DiSC3 5 induces plasma membrane hyperpolarization in Ehrlich ascites tumor cells Based on these pharmacological properties DiSC3 5 holds research potential in mitochondrial membrane potential detection and cellular bioenergetics studies