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An N-nitrosamine; induces the formation of esophageal, pharyngeal, and tongue tumors in rats at 200 mg/L in the drinking water or 15 mg/ml via oral gavage; toxic to rats (LD50s = 336 and 225 mg/kg for male and female rats, respectively); reduces survival of hamsters but only induces a low incidence of tumors at 5 mg/week for a total dose of 1.8 mmol
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N-Nitroso-3-azabicyclo[3.3.0]octane-d4 is the deuterium labeled N-Nitroso-3-azabicyclo[3.3.0]octane. It is used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development.
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Deuteration can impact the pharmacokinetic and metabolic profiles of drugs
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
N-Nitroso-3-azabicyclo[3.3.0]octane-d4 is the deuterium-labeled isotopologue of N-nitroso-3-azabicyclo[3.3.0]octane provided as a reference material for analytical and research applications. It is supplied as a solid for use as an internal standard in mass spectrometry and isotopic labeling studies; not for human or veterinary use.
Deuterium-labeled internal standard for mass spectrometry.
Suitable for quantitative and qualitative analytical methods.
Provided with batch-specific certificate of analysis.
Stable solid form suitable for recommended long-term storage.
Intended for research use only.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An N-nitrosamine; induces the formation of esophageal, pharyngeal, and tongue tumors in rats at 200 mg/L in the drinking water or 15 mg/ml via oral gavage; toxic to rats (LD50s = 336 and 225 mg/kg for male and female rats, respectively); reduces survival of hamsters but only induces a low incidence of tumors at 5 mg/week for a total dose of 1.8 mmol
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
N-Nitroso-N-methylurea is a potent carcinogen, mutagen, and teratogen. It acts as a direct-acting alkylating agent that interacts with DNA, targeting multiple animal organs to induce various cancers and/or degenerative diseases. It is also utilized as a precursor in the synthesis of diazomethane.
Potent carcinogen, mutagen, and teratogen
Direct-acting alkylating agent that interacts with DNA
Targets multiple animal organs to induce various cancers and/or degenerative diseases
Precursor in the synthesis of diazomethane
Can be used to construct rat tumor models
Increases cellular NF-κB activity and I-κBα phosphorylation in human malignant keratinocytes
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More