Phenylpropanoids and polyketides
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
Medchemexpress LLC Fotagliptin benzoate | 1403496-40-1 | 99.2% | 464.49 | C24H25FN6O3 | 50MG
Fotagliptin benzoate is the benzoate salt of a potent dipeptidyl peptidase-4 (DPP-4) inhibitor supplied for preclinical research into Type 2 diabetes mellitus. It is offered in solid and solution formats and is characterized by high purity and defined storage recommendations for stability.
Cayman Chemical CurcumIn-d6 500ug
An internal standard for the quantification of curcumin by GC- or LC-MS
Medchemexpress LLC 2-Propenoic acid, 3-(4-hydroxyphenyl)-,(2E)- | 501-98-4 | 164.16 | 1 G
p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. It inhibits cell proliferation, promotes apoptosis, and exhibits antibacterial, anti-inflammatory, antioxidant, and anti-tumor activities. It is for research use only.
- Inhibits cell proliferation.
- Promotes apoptosis.
- Exhibits antibacterial activity.
- Exhibits anti-inflammatory activity.
- Exhibits antioxidant activity.
- Exhibits anti-tumor activities.
Cayman Chemical Apigenin Inhibitors
Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression
Medchemexpress LLC m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
Cayman Chemical Tangeretin Neurochemicals
A polymethoxylated flavone isolated from citrus peels; inhibits signaling in cancer cells, reducing ERK signaling in T47D breast cancer cells (IC50 ~3 μM)
Medchemexpress LLC Doxorubicin hydrochloride | 25316-40-9 | C₂₇H₃₀ClNO₁₁ | 5 MG
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic and an anti-cancer chemotherapy agent. It is a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. It also induces apoptosis and autophagy.
- Potent human DNA topoisomerase I and topoisomerase II inhibitor
- Reduces basal phosphorylation of AMPK
- Induces apoptosis and autophagy
- Used in infection and cancer research
Cayman Chemical EUK 118 Neurochemicals
A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134
Medchemexpress LLC BIIE-0246 (AR-H 053591) | 246146-55-4 | 99.1% | 896.05 g/mol | C49H57N11O6 | 100 MG
BIIE-0246 (AR-H 053591) is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor used as a research reagent to probe NPY2R-mediated signaling. It is provided as a solid powder for in vitro and in vivo applications, with a reported IC50 of approximately 15 nM (rat [125I]PYY3-36). Intended for research use only.
- Potent, selective NPY Y2 receptor antagonist (IC50 ≈ 15 nM).
- Supplied as a solid powder suitable for in vitro and in vivo studies.
- High purity (reported ≥99.1%).
- Available in multiple pack sizes and solution formats for convenience.
- Intended for research use only; not for human or clinical use.
Cayman Chemical EpIcatechIn Galate 10mg
A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus