Phenylpropanoids and polyketides
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 g/mol | C15H12O3 | 1 G
3'-Hydroxyflavanone is a cyclized flavanone (C15H12O3) reported to induce apoptosis in HeLa cells and to possess antitumor activity in cellular studies. It is employed in biochemical and pharmacological research to probe apoptosis pathways and to study flavonoid bioactivity.
- Cyclized flavanone scaffold with a 3'-hydroxy substitution.
- Reported to induce apoptosis in HeLa cells.
- Demonstrated antitumor activity in preclinical cellular studies.
- Useful as a biochemical probe for apoptosis-related pathways.
- Supplied as a solid with defined molecular formula and molecular weight.
Selleck Chemical LLC Naringin S2329-1g
Naringin (Naringoside) is a flavanone glycoside which exerts a variety of pharmacological effects such as antioxidant activity blood lipid lowering anticancer activity and inhibition of cytochrome P450 enzymes
Selleck Chemical LLC AMG 487
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8 0 nM and 8 2 nM respectively
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 | C15H12O3 | 100 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is intended for in vitro biochemical and cellular studies and is supplied with an accompanying datasheet for characterization and safety information.
- Cyclized flavanone structure suitable for flavonoid research.
- Reported to induce apoptosis in HeLa cells.
- Reported antitumor activity in literature.
- Available in multiple pack sizes from milligram to gram quantities.
- Supplied in high-purity grades with supporting datasheet.
TARGETMOL CHEMICALS INC PHILLYRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Phillyrin (Forsythin) is a novel AMPK activator has anti-obesity effects in nutritive obesity mice it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting it potentially contributes to the suppression of the activation of MAPK and NF-(kappa)B pathways it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. purity: 99%
![Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 | C26H32O4 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238635.png-250.jpg)
Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 | C26H32O4 | 10MG
PSB-SB-487 is a coumarin-derived research compound that acts as a potent GPR55 antagonist and CB2 receptor agonist, used in preclinical studies of metabolic disorders, neurodegeneration, neuropathic pain, and cancer. It is supplied for laboratory research in multiple small-mass quantities and includes chemical identifiers and structural data for experimental reproducibility.
- Potent GPR55 antagonist and CB2 agonist.
- Molecular formula C26H32O4 and molecular weight 408.53.
- High purity (98.0%) suitable for research applications.
- Available in small-mass sizes for laboratory experiments.
- Relevant for studies of metabolic disorders, neurodegeneration, pain, and cancer.
- Provided with CAS number and structural identifiers for traceability.
eMolecules 2'-Hydroxyflavone | 35244-11-2 | MFCD00017673 | 1g
Combi-Blocks, Inc. | 2'-Hydroxyflavone | 1g | 603134286 | HA-3429 | 95.000 | 35244-11-2 | MFCD00017673 | 238.242 | C15H10O3
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TARGETMOL CHEMICALS INC AST 487 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AST 487 (NVP-AST 487) is a RET kinase inhibitor inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3. purity: 99%
![Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286670.png-250.jpg)
Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG
AST-487 is a small-molecule RET kinase inhibitor provided for laboratory research. It inhibits RET autophosphorylation and downstream signaling (reported RET IC50 ≈ 880 nM) and shows activity against FLT3 (IC50 ≈ 520 nM) and several other kinases. The compound is supplied as a solid and as a DMSO solution and is intended for research use only.
- Inhibits RET kinase with reported IC50 ≈ 880 nM.
- Shows activity against FLT3 with reported IC50 ≈ 520 nM.
- Chemical formula C26H30F3N7O2; molecular weight ≈ 529.6 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High supplier-reported purity (98.9% by supplier specification).
- Intended for research use only; not for clinical or human therapeutic use.
TARGETMOL CHEMICALS INC AMG 487 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Purity 99.89%
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 100 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487, which acts as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with high purity.
- High purity: 99.94%
- Antagonist of chemokine receptor CXCR3
- Stable as powder at -20°C for 3 years, and 4°C for 2 years
- Stable in solvent at -80°C for 2 years, and -20°C for 1 year
- Soluble in DMSO at 100 mg/mL
Selleck Chemical LLC AMG 487
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8 0 nM and 8 2 nM respectively
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | MFCD00016762 | 272.25 g/mol | C15H12O5 | 10 MG
Naringenin chalcone is a tetrahydroxychalcone flavonoid intermediate supplied for laboratory research and analytical applications. It is used in studies of flavonol biosynthesis and in biological assays where its reported activities (apoptosis induction, anti-inflammatory, anti-allergic, and anticancer effects) are relevant.
- Research reagent for studies of flavonol biosynthesis.
- Reported biological activities include apoptosis induction and anti-inflammatory effects.
- Suitable for analytical applications and small-scale laboratory assays.
- Molecular weight 272.25 g/mol; chemical formula C15H12O5.
- CAS number 73692-50-9; supplied in small package sizes for research use.