Phenylpropanoids and polyketides
Medchemexpress LLC Dihydrocoumarin | 119-84-6 | 148.16 | 25 G
Dihydrocoumarin is a compound found in *Melilotus officinalis*. It acts as a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
- Yeast Sir2p inhibitor
- Inhibits human SIRT1 (IC50 of 208 μM)
- Inhibits human SIRT2 (IC50 of 295 μM)
- Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay
- Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner
- Increases p53 lysine 373 and 382 acetylation in the TK6 cell line
Sigma Aldrich Fine Chemicals Biosciences Dihydrocoumarin >=99%, FCC, FG | 119-84-6 | MFCD00006881 | 1KG
Dihydrocoumarin >=99%, FCC, FG | Purity: >=99% | Mol Wt: 148.16 | 119-84-6 | MFCD00006881 | 1KG
Medchemexpress LLC Rifabutin | 72559-06-9 | 99.2% | 847.00 | 25 MG
Rifabutin is a semisynthetic ansamycin antibiotic that exhibits potent antimycobacterial properties by inhibiting DNA-dependent RNA polymerase. It is primarily used as a bactericidal agent for treating tuberculosis and is effective against a range of resistant mycobacteria, including Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. It also acts as an antibiotic and antitumor agent, influencing HSP-90 molecular chaperone and inactivating bacterial RNA polymerase.
- Semisynthetic ansamycin antibiotic
- Inhibits DNA-dependent RNA polymerase
- Bactericidal against resistant mycobacteria
- Effective against Gram-positive and some Gram-negative bacteria
- Treats tuberculosis and other mycobacterial infections
- Acts as an antitumor agent
- Modulates HSP-90 molecular chaperone
- Inactivates bacterial RNA polymerase
Medchemexpress LLC Rifabutin | 72559-06-9 | 99.15% | 847.00 | 500 MG
Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. It inhibits DNA-dependent RNA polymerase. It is primarily a bactericidal antibiotic used to treat tuberculosis.
- Inhibits DNA-dependent RNA polymerase
- Effective against highly resistant mycobacteria, Gram-positive, and some Gram-negative bacteria
- Active against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare
- Acts as an antitumor agent
- Interferes with HSP-90 molecular chaperone
- Enhances ubiquitination and protein degradation
Medchemexpress LLC Seratrodast (Standard) | 112665-43-7 | 98.2% | 100 MG
Seratrodast (Standard) | 112665-43-7 | 98.2% | 100 MG
Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 25 MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent, a thromboxane A2 receptor (TP) antagonist, and a ferroptosis inhibitor. It reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. This compound exhibits anti-asthmatic and anti-epileptic activity.
- Thromboxane A2 receptor (TP) antagonist
- Ferroptosis inhibitor
- Reduces lipid ROS production
- Modulates the systemic xc-/GSH/GPX4 axis
- Inhibits JNK phosphorylation and p53 expression
- Exhibits anti-asthmatic activity
- Exhibits anti-epileptic activity
- For research use only
Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 5 MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent that functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor. It operates by reducing lipid reactive oxygen species (ROS) production, modulating the systemic xc-/GSH/GPX4 axis, and inhibiting JNK phosphorylation and p53 expression. This compound exhibits both anti-asthmatic and anti-epileptic activities.
- Inhibits ferroptosis induced by RSL3 or Erastin in HT22 cells.
- Down-regulates the phosphorylation level of JNK.
- Inhibits ROS generation and lipid peroxidation induced by Erastin in HT22 cells.
- Shows no significant cytotoxicity at concentrations below 10 μM in HT22 cells.
- Prevents cell death in HT22 cells induced by ferroptosis inducers.
- Inhibits neuronal ferroptosis in a pentylenetetrazole-induced mouse epilepsy model.
- Reduces epileptic seizures in vivo.
Medchemexpress LLC Seratrodast (Standard) | 112665-43-7 | 98.2% | 50 MG
Seratrodast (Standard) is the analytical standard for Seratrodast, designed for research and analytical applications. It functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor, demonstrating anti-asthmatic and anti-epileptic properties.
- Analytical standard for Seratrodast
- Thromboxane A2 receptor (TP) antagonist
- Ferroptosis inhibitor
- Decreases lipid reactive oxygen species (ROS) production
- Regulates the systemic xc-/GSH/GPX4 axis
- Suppresses JNK phosphorylation and p53 expression
- Exhibits anti-asthmatic and anti-epileptic activity
- Commonly utilized in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Luteolin monohydrate | 6113-16-2 | 99.1% | 304.25 | C15H12O7 | 500 MG
Luteolin monohydrate is the monohydrate form of luteolin, a naturally occurring flavonoid used in biochemical and pharmacological research. It is reported to act as an Nrf2 inhibitor and has documented anti-inflammatory and anticancer activities. Supplied as a solid with high reported purity for laboratory studies.
- High purity: 99.1%.
- Flavonoid with reported anti-inflammatory and anticancer activity.
- Reported Nrf2 inhibitor activity.
- Molecular formula C15H12O7; molecular weight 304.25.
- Available in a 500 mg pack for laboratory use.
Medchemexpress LLC Luteolin | 491-70-3 | MFCD00017309 | 98.7% | 286.24 g/mol | C15H10O6 | 10 MG
Luteolin is a purified flavonoid analytical reference standard supplied as a solid for laboratory use. It is intended for assay calibration, method development, and quality control, and is provided with a certificate of analysis and safety data sheet.
- High purity reference standard (≈98.7%).
- Chemical formula C15H10O6; molecular weight 286.24 g/mol.
- Solid, white to light yellow powder for straightforward handling.
- Suitable for analytical testing, method validation, and QC workflows.
- Supplied with COA and SDS for traceability and safe handling.
- Available in small analytical pack sizes for laboratory use.
Medchemexpress LLC Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) | 19833-12-6 | 1 MG
Myricetin 3-O-glucoside is a flavonol found in *Tibouchina paratropica* and Hakmeitau beans. It demonstrates anti-Leishmanial, anti-inflammatory, and antimicrobial activities. This product is for research use only.
- Demonstrates anti-Leishmanial activity
- Demonstrates anti-inflammatory activity
- Demonstrates antimicrobial activity
- Found in *Tibouchina paratropica* and Hakmeitau beans
Medchemexpress LLC (-)-Epigallocatechin Gallate (Standard) | 989-51-5 | 98.1% | 458.37 | 50 MG
(-)-Epigallocatechin Gallate (Standard) is an analytical standard and a major polyphenol found in green tea. It is intended for research and analytical applications, known for its ability to inhibit cell proliferation and induce cell apoptosis. It also inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity and possesses potent anticancer, antioxidant, and anti-inflammatory properties.
- Analytical standard for (-)-Epigallocatechin Gallate.
- Intended for research and analytical applications.
- Potent anticancer, antioxidant, and anti-inflammatory properties against various cancers like colorectal cancer, myeloid leukemia, and thyroid carcinoma.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS as a reference standard.
Medchemexpress LLC (-)-Gallocatechin | 3371-27-5 | 306.27 | 1 ML
(-)-Gallocatechin is an epimer of (-)-Epigallocatechin (EGC) found in various tea products. It demonstrates significant antioxidant activity in vitro through several mechanisms.
- Epimer of (-)-Epigallocatechin (EGC).
- Demonstrates antioxidant activity in vitro.
- Inhibits LDL oxidation.
- Scavenges DPPH radicals.
- Inhibits thiobarbituric acid-reactive substances (TBARS) production.
- Exhibits antioxidant activity in the Ferric reducing-antioxidant power (FRAP) assay.
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 1 ML
Myricetin is a common plant-derived flavonoid with a wide range of activities, including strong anti-oxidant, anticancer, antidiabetic, and anti-inflammatory properties. It is also an autophagy inducer and is for research use only.
- Strong anti-oxidant activity
- Anticancer activity
- Antidiabetic activity
- Anti-inflammatory activity
- Autophagy inducer