Phenylpropanoids and polyketides
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 100 G
4-Hydroxycoumarin is an orally active coumarin derivative, serving as a versatile heterocyclic scaffold for organic compound synthesis. It exhibits both electrophilic and nucleophilic properties. This compound acts as an HIV protease and tyrosine kinase inhibitor, demonstrating anti-inflammatory, antibacterial, and anti-tumor effects. It is primarily utilized as a laboratory chemical and in the manufacturing of various substances.
- Orally active coumarin derivative
- Versatile scaffold for organic synthesis
- Inhibits HIV protease and tyrosine kinase
- Exhibits anti-inflammatory, antibacterial, and anti-tumor effects
- Primarily used as a laboratory chemical
- Solid physical state, off-white appearance
- Chemically stable under normal conditions
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 100 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis*, demonstrating anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity through the ERK/Nrf2/HO-1 pathway, and inhibits PKM2, COX-2, and 5-LOX. This compound is orally active.
- Isolated from *Clerodendrum phlomidis*
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2 with an IC50 of 2.12 μM
- Inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL
- Orally active
- Ameliorates neuropathic pain in mice models
- Improves high-fat diet-induced non-alcoholic fatty liver disease
- Reduces malondialdehyde (MDA) and ROS levels in HepG2 cells
Medchemexpress LLC Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) | 19833-12-6 | 1 MG
Myricetin 3-O-glucoside is a flavonol found in *Tibouchina paratropica* and Hakmeitau beans. It demonstrates anti-Leishmanial, anti-inflammatory, and antimicrobial activities. This product is for research use only.
- Demonstrates anti-Leishmanial activity
- Demonstrates anti-inflammatory activity
- Demonstrates antimicrobial activity
- Found in *Tibouchina paratropica* and Hakmeitau beans
Medchemexpress LLC (-)-Epigallocatechin Gallate-d4 (EGCG-d4) | 989-51-5 | 97.14% | 462.40 | 1 MG
(-)-Epigallocatechin Gallate-d4 (EGCG-d4) | 989-51-5 | 97.14% | 462.40 | 1 MG
Medchemexpress LLC 4'-Hydroxyflavone | 4143-63-9 | MFCD00017687 | 97.0% | 238.24 g/mol | C15H10O3 | 10 MG
4'-Hydroxyflavone is a flavone-class small molecule used in research as an aldose reductase inhibitor. It is supplied as a high-purity research reagent for biochemical assays and is commonly used in enzyme inhibition studies, structure-activity relationship (SAR) investigations, and small-molecule screening.
- High purity (97.0%)
- Molecular formula C15H10O3
- Molecular weight 238.24 g/mol
- CAS number 4143-63-9
- Reported aldose reductase IC50 12 μM
- Suitable for enzyme inhibition assays and SAR studies
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC 5-Hydroxyflavone | 491-78-1 | 99.83% | 238.24 | 1 ML
5-Hydroxyflavone is a flavonoid ligand that exhibits no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells. It is intended for research use only.
- Available in solid and solution forms.
- Solid and solvent options available for reconstitution.
- Powder storage: -20°C for 3 years; 4°C for 2 years.
- In solvent storage: -80°C for 2 years; -20°C for 1 year.
- Soluble in DMSO.
AdipoGen 6 7-Diethoxy-4-CF3 coumarin
Chemical. CAS 351002-66-9. Formula C14H13F3O4. MW 302.25. Synthetic. Fluorescent labelling.
Medchemexpress LLC Ethyl (E)-p-hydroxycinnamate | 7362-39-2 | MFCD00210460 | 99.2% | 192.21 g/mol | C11H12O3 | 10 MG
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-coumaric acid, used in biochemical research as a reversible, non-competitive inhibitor of tyrosinase and as a building block in studies of enzyme inhibition, formulation, and cosmetic or food preservation research.
- Reversible, non-competitive tyrosinase inhibitor (activity reported by manufacturer).
- High purity: 99.19% (manufacturer reported).
- Molecular weight 192.21 g/mol and formula C11H12O3.
- Available as solid (5 mg, 10 mg, 25 mg, 50 mg, 100 mg) and as a 10 mM solution in DMSO for ready-to-use assays.
- Suitable for medicinal, cosmetic, and fruit preservation research applications.
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 100mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC Luteolin monohydrate | 6113-16-2 | 99.1% | 304.25 g/mol | C15H12O7 | 1 ML
Luteolin monohydrate is the monohydrate form of luteolin, a flavonoid research reagent reported to have anti-inflammatory and anticancer activity. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and as solid quantities for laboratory use, and is intended for research applications.
- Ready-to-use 10 mM solution in DMSO for convenient dosing
- High purity (99.1%) for reproducible results
- Suitable for cell-based and biochemical assays
- Solid forms available for bulk use (100 MG-5 G)
- Molecular formula C15H12O7 and molecular weight 304.25 g/mol
- Storage recommendations provided for solid and solution forms
eMolecules 2-(4-Isobutylphenyl)propan-1-ol | 36039-36-8 | MFCD08275583 | 250mg
Ambeed | 2-(4-Isobutylphenyl)propan-1-ol | 250mg | 600850643 | A990518 | | 36039-36-8 | MFCD08275583 | 192.302 | C13H20O
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Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | MFCD06795644 | >98.0% | 10 MG
Ozagrel hydrochloride is the hydrochloride salt of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor used in preclinical research to study platelet aggregation, ischemic stroke, asthma, and thromboembolic disease.
- Selective thromboxane A2 (TXA2) synthase inhibitor with reported IC50 ~11 nM.
- Reduces thromboxane A2 production, leading to anti-platelet aggregation and vasodilation.
- Hydrochloride salt supplied as a powder suitable for in vitro and in vivo research.
- Typical molecular weight 264.71 g/mol and formula C13H13ClN2O2.
- High purity commonly reported as ≥98% (verify with vendor for specific lot).
- Store powder at -20°C for long-term stability; in solution, store at -80°C.
Supply Solutions Avantor Performance Materials Mineral Oil Light NF 20L; Size: 20L; Grade: NF; Container Material: Steel Pail
Avantor Performance Materials Mineral Oil Light NF 20L; Size: 20L; Grade: NF; Container Material: Steel Pail
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | 1 ML
7-Methylcoumarin is a coumarin derivative known for its potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6 and has been shown to reduce liver damage markers and oxidative stress. It significantly reduces alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, while restoring total protein (TP) and albumin (TA) levels in serum.
- Acts as a mechanism-based inhibitor for human CYP2A6.
- Causes chromosomal aberrations in A. sativum Promeristem.
- Restores elevated levels of ALT and AST to near normal in rats.
- Restores antioxidant enzyme and TBARS levels.
- Restores serum TB and TP levels to near normal.
- Reduces hepatic lesions induced by CCl4.