Phenylpropanoids and polyketides
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
![eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3733135.jpg-250.jpg)
eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 10mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 1 ML
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, inhibits Apoptosis, and improves insulin resistance and insulin sensitivity.
- Potent and orally active curcumin analog
- Inhibits lipid droplet formation
- Increases autophagy
- Inhibits apoptosis
- Improves insulin resistance and insulin sensitivity
- Decreases palmitic acid (PA)-induced SREBP1 expression levels in AML12 cells
- Ameliorates insulin resistance and hepatic steatosis in mice with high-fat diet-induced obesity
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 25 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Curcumin 5-8 also improves insulin resistance and insulin sensitivity. This product is for research use only and not sold to patients.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
- For research use only and not sold to patients.
Selleck Chemical LLC AG 494
AG-494 a member of the tyrphostin family of tyrosine kinase inhibitors is a potent inhibitor of EGF receptor autophosphorylation (IC50 1 2 M) and EGF-dependent cell growth (IC50 6 M)
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | 99.2% | 305.29 g/mol | C14H15N3O5 | 5 MG
Entacapone (Standard) is an analytical reference standard of entacapone provided for research and analytical use. Supplied in small quantitative sizes suitable for assay development, method validation, and quality control, the product includes batch documentation and a Certificate of Analysis reporting high purity. It is used as a reference material in studies involving COMT inhibition and related biochemical assays.
- Analytical standard for assay development and method validation.
- Available in small sizes, including a 5 mg vial.
- Certified purity approximately 99.2% (COA available).
- Useful for quality control and reference material applications.
- Molecular formula C14H15N3O5; molecular weight 305.29 g/mol.
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | >98.0% | C19H20O2 | 10MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one (CAS 100667-52-5) is a diarylheptanoid research chemical used as a biochemical reagent for laboratory studies. It appears as a white to off-white solid and is characterized by molecular formula C19H20O2 and a molecular weight of 280.4 g/mol. The compound is provided in small research-scale quantities for analytical, assay, and synthetic applications.
- High purity (>98.0%).
- Accurate molecular formula C19H20O2.
- Suitable for assay and analytical use in research settings.
- Supplied in small milligram package sizes for laboratory workflows.
- Includes standard structural identifiers for cheminformatics (SMILES, InChIKey).
Selleck Chemical LLC Tyrphostin AG-528
Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4 9 M and 2 1 M respectively Tyrphostin AG-528 exhibits anticancer activity
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Medchemexpress LLC α-cyano-4-hydroxycinnamic acid | 28166-41-8 | MFCD00004204 | 99.9% | 189.17 | C10H7NO3 | 1 ML
α-Cyano-4-hydroxycinnamic acid is a small-molecule inhibitor of monocarboxylate transporters commonly used in biochemical research and as a matrix in mass spectrometry. It is supplied at high purity and is available as both solid material and as a ready-to-use 10 mM solution in DMSO for laboratory use.
- High purity (99.9%) suitable for sensitive assays.
- Available as a 10 mM solution in DMSO for immediate use.
- Also available as solid in multiple sizes for flexible use.
- Effective monocarboxylate transporter inhibitor for in vitro studies.
- Suitable as a MALDI matrix for peptide analysis.
- Datasheet, certificate of analysis, and safety data sheet available.
Medchemexpress LLC Ferulic acid acyl-β-D-glucoside | 7196-71-6 | 10 MG
Ferulic acid acyl-β-D-glucoside is a metabolite of ferulic acid. It can be isolated from flaxseed extract. Ferulic acid is identified as a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor.
- Metabolite of ferulic acid.
- Can be isolated from flaxseed extract.
- Acts as a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50 values of 3.78 and 12.5 μM for FGFR1 and FGFR2.
- Purity: 99.33%.
Medchemexpress LLC 3,4-Dimethoxycinnamic acid | 2316-26-9 | 208.21 | 5 G
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effects.
- Extracted and purified from Securidaca inappendiculata Hassk.
- Exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway.
- Anti-apoptotic effects.
Medchemexpress LLC Ethyl α-D-galactoside | 15486-24-5 | ≥97.0% | 208.21 g/mol | C8H16O6 | 10 MG
Eleutheroside C (Ethyl α-D-galactoside) is a naturally occurring glycoside isolated from the bulbs of Polianthes tuberosa and supplied for laboratory research use. The compound is provided in milligram-scale quantities and is characterized by a reported molecular weight of 208.21 g/mol, CAS 15486-24-5, and a stated purity of ≥97%.
- Intended for research use only, not for human or veterinary use.
- High stated purity for analytical and biochemical applications.
- Supplied in milligram-scale quantities for small-scale experiments.
- Characterized by published molecular weight and CAS registry number for traceability.