Rosuvastatin-d6 sodium is deuterium labeled Rosuvastatin sodium. It is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. This compound potently blocks hERG current with an IC50 of 195 nM, reduces the expression of mature hERG, and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS