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Commonly in liquid form and available in various chemical compositions, solvents are substances that dissolve solutes to form solutions. The amount and type of solute that a solvent can dissolve is dependent upon temperature and polarity.
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Valproic acid-d4 is the deuterium labeled Valproic acid Valproic acid (VPA 2-Propylpentanoic Acid) is an HDAC inhibitor with IC50 in the range of 0 5 and 2 mM also inhibits HDAC1 (IC50 400 M) and induces proteasomal degradation of HDAC2 Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells Valproic acid sodium salt is used in the treatment of epilepsy bipolar disorder and prevention of migraine headaches[1 [2
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Amisulpride-d5 is the deuterium-labeled analogue of amisulpride used as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS. Supplied as a high-purity deuterated solid, it is intended for analytical and research applications where accurate quantitation is required.
Deuterium-labeled internal standard for mass spectrometry and NMR.
High deuteration purity (≈98.8%) for reliable quantitation.
Suitable as tracer and internal standard in bioanalytical assays.
Supplied as a 10 mg solid for small-scale analyses.
Molecular formula C17H22D5N3O4S; molecular weight 374.51 g/mol.
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Amisulpride-d5 is the deuterium-labeled form of Amisulpride, a dopamine D2/D3 receptor antagonist. It has Ki values of 2.8 nM for human dopamine D2 and 3.2 nM for human dopamine D3. This product is suitable for research applications, including use as a tracer and an internal standard for quantitative analysis.
Deuterium labeled
Dopamine D2/D3 receptor antagonist
High purity: 98.27%
Appearance: solid, white to off-white
Can be used as a tracer
Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Valuable for pharmacokinetic and metabolic studies
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This product is a stable isotope-labeled compound, specifically a deuterium-labeled version of a MEK inhibitor. It is an orally active inhibitor that targets MEK1 and MEK2, demonstrating activity at very low concentrations. The compound is noted for its ability to activate autophagy and induce apoptosis. It is intended for research use only and not for human therapeutic applications.
Features
Deuterium labeled compound.
Targets MEK1 and MEK2 with high potency.
Activates autophagy.
Induces apoptosis.
Oral activity.
Benefits
Can be used as a tracer in research.
Serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
Deuterium substitution may influence pharmacokinetic and metabolic profiles of drugs.
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Trametinib-d4 is the deuterium-labeled version of Trametinib. Trametinib is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of approximately 2 nM. It also activates autophagy and induces apoptosis.
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Deuterium substitution has the potential to impact the pharmacokinetic and metabolic profiles of drugs
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Trametinib-d4 is the deuterium labeled Trametinib. Trametinib is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. It activates autophagy and induces apoptosis.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation.
Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
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Amisulpride-d5 is the deuterium-labeled form of amisulpride intended for research use as a tracer or internal standard. It maintains the pharmacological profile as a dopamine D2/D3 receptor antagonist and is provided as a white to off-white solid suitable for quantitative analyses by NMR, GC-MS, or LC-MS.
Deuterium-labeled for isotope-dilution assays.
Suitable as an internal standard for NMR, GC-MS, and LC-MS.
High purity (≈98.8%) appropriate for analytical applications.
Soluble in DMSO and sparingly soluble in water; ultrasonic assistance recommended.
Stable as a powder at -20°C for long-term storage.
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Ilaprazole-d3 is a deuterium-labeled analogue of ilaprazole intended for use as a tracer and internal standard in analytical research. Supplied in small quantities for laboratory use, it supports accurate quantification in metabolic and pharmacokinetic studies using MS and NMR techniques.
Deuterium-labeled analogue for isotope tracing.
Suitable as an internal standard for quantitative LC-MS, GC-MS, and NMR.
Molecular formula C19H15D3N4O2S; molecular weight 369.46 g·mol⁻¹.
Provided in small, research-scale quantities for analytical workflows.
Refer to certificate of analysis for lot-specific purity and handling information.
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