Diterpenoids
TARGETMOL CHEMICALS INC Cryptotanshinone 50MG
Also available in 1 mL, 10 mg, 25 mg, 100 mg and bulk. Please contact Fisher for quotes. Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50 4.6 uM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5. Purity 98.1%
Medchemexpress LLC Tanshinone I | 568-73-0 | MFCD00210563 | 98.8% | 276.29 g/mol | C18H12O3 | 10 MG
Analytical standard of Tanshinone I supplied as a high-purity reference material for research and analytical use. It is intended for qualitative and quantitative analysis, method development, calibration, and identity/purity testing by techniques such as liquid chromatography, gas chromatography, and mass spectrometry. Reported purity ≈98.8% and CAS 568-73-0.
- Intended for analytical applications such as LC, GC, and MS.
- High purity suitable for calibration and quantitative analysis.
- Useful for method development and identity and purity testing.
- Available in small research quantities for laboratory use.
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-10mM/1mL
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
Medchemexpress LLC Tanshinone IIB | 17397-93-2 | 310.34 | 1 MG
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) which is widely used for the research of stroke and coronary heart disease in Asian countries. It has a neuroprotective effect via inhibition of apoptosis.
Medchemexpress LLC Tanshinone IIA anhydride | 61077-78-9 | 310.34 | 1 MG
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor. It has Ki values of 1.9 nM for human CE1 and 1.4 nM for human intestinal CE (hiCE).
- Potent and irreversible human carboxylesterase (CE) inhibitor
- Ki values of 1.9 nM for human CE1
- Ki values of 1.4 nM for human intestinal CE (hiCE)
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 500 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. This compound acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is primarily used in the treatment of cardiovascular disorders. It is intended for research purposes only.
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs.
- Suppresses TRPC1 and TRPC6 expression.
- Inhibits basal calcium concentration and SOCE.
- Primarily inhibits CYP3A4 activities in vitro.
- Shows protective effects against Aβ-induced cell toxicity in SH-SY5Y cells.
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat models.
- Effectively prevents peritoneal adhesion in rats.
Medchemexpress LLC Cucurbitacin IIa | 58546-34-2 | 562.73 | 1 MG
Cucurbitacin IIa, also known as Hemslecin A, is an orally active EGFR inhibitor capable of permeating the blood-brain barrier. It demonstrates an IC50 of 1.455 nM against human EGFR and exhibits anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway.
Features and Benefits:
- Induces caspase-3-dependent apoptosis.
- Downregulates survivin expression.
- Enhances autophagy levels.
- Disrupts the actin cytoskeleton via actin aggregation.
- Arrests the cell cycle at the G2/M phase.
- Supports research into inflammation-related diseases.
- Useful in studies on depression and cancers like non-small cell lung cancer.
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 97.0% | 278.32 g/mol | C14H14O4S | 5 MG
This bisphenol-derived small-molecule inhibits DNA topoisomerase II alpha and is intended for research use. It demonstrates topo II inhibitory activity and in vitro cell growth inhibition, making it suitable for biochemical and anticancer studies.
- Small-molecule inhibitor of DNA topoisomerase II alpha.
- Bisphenol-derived structure; formula C14H14O4S.
- Documented in vitro topo II inhibitory activity and cell growth IC50 values.
- Supplied in small quantities for research use (5 mg pack).
- Intended for biochemical and anticancer research applications.
Apexbio Technology LLC Tanshinone IIA 568-72-9 20mg
Tanshinone IIA (CAS 568-72-9) is a diterpene quinone extracted from the medicinal plant Salvia miltiorrhiza (Danshen) It modulates cellular signaling by inhibiting the binding of transcription factors NF- B and AP-1 to DNA thereby regulating gene expression associated with inflammation and proliferation Tanshinone IIA has demonstrated the capacity to suppress -amyloid aggregation and protect neuronal PC12 cells against -amyloid-induced apoptosis It exhibits both antioxidant and anti-inflammatory properties supporting its use in studies related to oncology neurodegeneration and inflammation
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA >=97% (HPLC) | 568-72-9 | MFCD00238692 | 5MG
Tanshinone IIA >=97% (HPLC) | Purity: >=97% (HPLC) | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 5MG
Medchemexpress LLC Cucurbitacin IIa | 58546-34-2 | 562.73 | 1 ML
Cucurbitacin IIa, also known as Hemslecin A, is an orally active and blood-brain barrier-permeable EGFR inhibitor, demonstrating an IC50 of 1.455 nM against human EGFR. It plays a role in inducing caspase-3-dependent apoptosis, downregulating survivin expression, and enhancing autophagy levels. This compound disrupts the actin cytoskeleton through actin aggregation, arrests the cell cycle at the G2/M phase, and provides anti-inflammatory effects by inhibiting the EGFR-MAPK signaling pathway.
- Orally active, blood-brain barrier-permeable EGFR inhibitor
- Induces caspase-3-dependent apoptosis
- Downregulates survivin expression
- Enhances autophagy levels
- Disrupts actin cytoskeleton via actin aggregation
- Arrests cell cycle at G2/M phase
- Exerts anti-inflammatory activity by inhibiting EGFR-MAPK signaling pathway
- Suitable for research in inflammation-related diseases, depression, and cancers
Selleck Chemical LLC Tanshinone IIA 50mg 568-72-9 Tanshinone B
Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Topoisomerase IIα-in-8 | 1251578-67-2 | 314.32 | C15H15FN6O | 1 MG
Topoisomerase IIα-IN-8 is a research-grade small-molecule inhibitor of human DNA topoisomerase IIα reported as a weak inhibitor (IC50 = 462 ± 38.0 μM). It is supplied as a powder for laboratory use, has molecular formula C15H15FN6O and molecular weight 314.32 g·mol-1, and is provided with downloadable product and safety documentation. For research use only.
- Weak inhibitor of human DNA topoisomerase IIα (IC50 = 462 ± 38.0 μM).
- Shows limited antiproliferative activity (GI50 > 100 μM in HEK293 and HT-29 cells).
- Supplied as a powder with specified storage recommendations for powder and solutions.
- Molecular formula C15H15FN6O; molecular weight 314.32 g·mol-1.
- Datasheet and safety data sheet available for handling and purity details.
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 500 UG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules as tracers for quantitation during the drug development process.