Diterpenoids
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 100mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 278.32 g/mol | C14H14O4S | 10 MG
Topoisomerase IIα-IN-9 (4,4'-sulfonylbis(2-methylphenol)) is a bisphenol compound that moderately inhibits human DNA topoisomerase II and reduces cell proliferation in selected cell lines. It is supplied for laboratory research; lot-specific purity, solubility, and storage conditions are provided in the product data sheet and Certificate of Analysis.
- Moderate topoisomerase II inhibition (IC50: 571 μM).
- Inhibits K562 cell growth (IC50: 117 μM) and CHO cell growth (IC50: 218 μM).
- Molecular weight 278.32 g/mol and formula C14H14O4S.
- CAS number 16346-97-7 for unambiguous identification.
- Intended for research use; consult Certificate of Analysis for purity and storage.
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 500mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 97.0% | 278.32 g·mol-1 | C14H14O4S | 25 MG
Topoisomerase IIα-IN-9 is a bisphenol-derived small-molecule inhibitor of human DNA topoisomerase IIα intended for research use. Reported biochemical activity includes Topo II inhibition (IC50 ≈ 571 μM) and cell growth inhibitory activity in K562 and CHO cells (IC50 ≈ 117 μM and 218 μM, respectively). Molecular formula C14H14O4S and molecular weight 278.32 g·mol-1 are provided; consult the Certificate of Analysis for purity and storage conditions.
- Moderate inhibitor of DNA topoisomerase IIα.
- Exhibits cell growth inhibition in selected cell lines.
- Provided as a characterized small molecule with formula and molecular weight.
- Suitable for biochemical assays and cell-based research applications.
- Certificate of Analysis available for purity and handling details.
Medchemexpress LLC Isophytol (isovegetable alcohol) | 505-32-8 | MFCD00048380 | 99.7% | 296.53 | C20H40O | 100 G
Isophytol (isovegetable alcohol) is a branched-chain diterpenoid alcohol provided for research use as a biochemical assay reagent. It is a clear, oily organic compound (C20H40O, MW 296.53) commonly used in biochemical and analytical applications; manufacturer-stated purity is approximately 99.7%.
- Biochemical assay reagent for life-science research.
- High nominal purity suitable for analytical applications.
- Clear, oily liquid form for easy formulation and handling.
- Supplied in multiple pack sizes for laboratory convenience.
Medchemexpress LLC 4,4'-sulfonylbis(2-methylphenol) | 16346-97-7 | MFCD00130281 | 97.0% | 278.32 g/mol | C14H14O4S | 5 MG
This bisphenol-derived small-molecule inhibits DNA topoisomerase II alpha and is intended for research use. It demonstrates topo II inhibitory activity and in vitro cell growth inhibition, making it suitable for biochemical and anticancer studies.
- Small-molecule inhibitor of DNA topoisomerase II alpha.
- Bisphenol-derived structure; formula C14H14O4S.
- Documented in vitro topo II inhibitory activity and cell growth IC50 values.
- Supplied in small quantities for research use (5 mg pack).
- Intended for biochemical and anticancer research applications.
Abcam Paclita x el, Anticancer agent, 10MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 5 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. It acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is used to treat cardiovascular disorders. This product is for research use only and not sold to patients.
- Inhibits store-operated Ca2+ entry (SOCE)
- Used to treat cardiovascular disorders
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation
- Suppresses TRPC1 and TRPC6 expression in hypoxic PASMCs
- Inhibits CYP3A4 activity
- Attenuates scopolamine-induced cognitive dysfunctions
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model
- Prevents peritoneal adhesion
Sigma Aldrich Fine Chemicals Biosciences Docetaxel purum, >=97.0% (HPLC) | 114977-28-5 | MFCD00800737 | 25MG
Docetaxel purum, >=97.0% (HPLC) | Purity: >=97.0% (HPLC) | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 | 25MG
Medchemexpress LLC Tanshinone IIB | 17397-93-2 | 310.34 | 1 MG
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) which is widely used for the research of stroke and coronary heart disease in Asian countries. It has a neuroprotective effect via inhibition of apoptosis.
Abcam Myricetin, irreversible Tr x R inhibitor, 5MG
MW 318.24 g/mol, Purity >97%. Directly inhibits MEK, JAK1, Akt and MKK4 kinase activity. Able to inhibit cytochrome P450 3A4 and 2C9 (IC₅₀ = 7.81 and 13.5 μM, respectively). .
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | 568-72-9 | MFCD00238692 | 20MG
Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 20MG
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 99.8% | 628.71 g/mol | C37H40O9 | 10 MG
Resiniferatoxin is a highly potent, naturally derived agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel. It is used in laboratory research to ablate or modulate TRPV1-expressing sensory neurons and to study pain signaling, neurobiology, and cardiac sympathetic afferent reflexes. Supplied as a high-purity solid with storage and solvent guidance, it is intended for research use only (not for human use).
- Potent TRPV1 agonist for targeted neuronal ablation and modulation.
- High chemical purity (99.77%) suitable for sensitive assays.
- Molecular weight 628.71 g/mol and formula C37H40O9.
- Stable solid; store protected from light at -20°C; in solution, store at -80°C for long-term stability.
- Soluble in DMSO; in vitro and in vivo vehicle preparation guidance available.
- Supplied in small milligram-scale quantities appropriate for research applications.