Diterpenoids
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-1g
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 5 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*. This compound has been extensively used for treating cardiovascular diseases and demonstrates an entry-blocking effect against MERS-CoV.
- Extracted from *Salvia miltiorrhiza Bunge*
- Used for treating cardiovascular diseases
- Exhibits entry-blocking effect for MERS-CoV
- Attenuates atherosclerosis in ApoE-/- mice
- Inhibits LOX-1, NOX4, and NF-κB expression in aorta
- Improves cardiac function and reduces infarct size in myocardial ischemia-reperfusion rats
- Induces caspase-dependent apoptosis and autophagy in colon cancer cells
- Potentially a safe, high-throughput screening compound for MERS-CoV entry inhibitors
- Purity: 99.57%
- Appearance: Solid, brown to red
Abcam Paclita x el, Anticancer agent, 10MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Paclitaxel-d5 (benzoyloxy) | 1261254-56-1 | 98.1% | C47H46D5NO14 | 500 UG
Paclitaxel-d5 (benzoyloxy) is the deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. It can cause both mitotic arrest and apoptotic cell death and also induces autophagy. This product is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC 7-Epi-docetaxel | 153381-68-1 | 98.8% | 807.88 | 1 ML
7-Epi-docetaxel is an impurity of docetaxel, intended for research use only. It is classified as a Microtubule/Tubulin Inhibitor within the Cytoskeleton signaling pathway.
- Impurity of docetaxel
- Classified as a microtubule/tubulin inhibitor
- Involved in cytoskeleton signaling pathway
- Suitable for research applications
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 ML
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, leading to cell cycle arrest at G2/M and subsequent apoptosis. This compound demonstrates anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Demonstrates anti-cancer activity
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 5 MG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. This compound is suitable for research applications.
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Cayman Chemical 10-acetyl Docetaxel 50mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 100 MG
Docetaxel (standard) is an analytical standard of Docetaxel, developed for research and analytical applications. It functions as a microtubule depolymerization inhibitor and attenuates the effects of bcl-2 and bcl-xL gene expression. This compound arrests the cell cycle at G2/M and induces cell apoptosis, demonstrating anti-cancer activity.
- Acts as a microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Induces cell apoptosis
- Utilized in qualitative, quantitative, and methodological research experiments (e.g., HPLC, GC, MS)
- Appears as a white to off-white solid
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma