Diterpenoids
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 25 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which functions by interfering with DNA polymerase activity to prevent mitotic cell division. This antibiotic, originating from the mold Cephalosporium aphidicola, is known for its ability to inhibit cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Furthermore, it demonstrates anti-orthopoxvirus activity and enhances apoptosis when induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Functions as an antibiotic
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
- Targets DNA/RNA synthesis, HSV, and apoptosis pathways
- Applied in infection and inflammation/immunology research
TARGETMOL CHEMICALS INC DIHYDROTANSHINONE I 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases. purity: 99%
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | 807.88 | C43H53NO14 | 10 MG
Docetaxel (standard) is an analytical reference of the chemotherapeutic agent docetaxel supplied for research and analytical applications. It acts as a microtubule depolymerization inhibitor that arrests cells at G2/M and promotes apoptosis. The product is provided in small vial sizes for laboratory workflows and is accompanied by supporting documentation (SDS, COA).
- High purity suitable for analytical applications.
- Molecular weight 807.88.
- CAS number 114977-28-5 for unambiguous identification.
- Available in multiple small vial sizes for flexibility in experiments.
- Intended for research and analytical use only.
Medchemexpress LLC Aphidicolin | 38966-21-1 | 1 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola*, inhibiting cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Interferes with DNA polymerase activity
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 99.8% | 628.71 g/mol | C37H40O9 | 10 MG
Resiniferatoxin is a highly potent, naturally derived agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel. It is used in laboratory research to ablate or modulate TRPV1-expressing sensory neurons and to study pain signaling, neurobiology, and cardiac sympathetic afferent reflexes. Supplied as a high-purity solid with storage and solvent guidance, it is intended for research use only (not for human use).
- Potent TRPV1 agonist for targeted neuronal ablation and modulation.
- High chemical purity (99.77%) suitable for sensitive assays.
- Molecular weight 628.71 g/mol and formula C37H40O9.
- Stable solid; store protected from light at -20°C; in solution, store at -80°C for long-term stability.
- Soluble in DMSO; in vitro and in vivo vehicle preparation guidance available.
- Supplied in small milligram-scale quantities appropriate for research applications.
Medchemexpress LLC Isophytol | 505-32-8 | MFCD00048380 | 99.7% | 296.53 g/mol | C20H40O | 500 G
Isophytol is a branched-chain terpene alcohol used as an organic reagent and intermediate in biochemical and life-science research. It is a colorless to light-yellow liquid commonly used in organic synthesis, assay development, and fragrance/intermediate applications.
- High purity, 99.7%.
- Liquid physical form; density ~0.841 g/cm3.
- Molecular weight 296.53 g/mol.
- Suitable for organic synthesis and assay development.
- Available in bulk packaging, including 500 g quantities.
Apexbio Technology LLC LDN 57444 668467-91-2 50mg
LDN 57444 (CAS 668467-91-2) is a reversible competitive inhibitor of ubiquitin C-terminal hydrolase-L1 (Uch-L1) displaying an IC50 of 0 88 M It also inhibits Uch-L3 with lower potency (IC50 25 M) In neuronal systems Uch-L1 inhibition by LDN 57444 results in reduced long-term potentiation and basal synaptic transmission effects resembling -amyloid-induced synaptic impairment Additionally in the rat insulinoma cell line INS 832/13 LDN 57444 triggers apoptosis characterized by increased caspase-3 activity and enhanced nuclear CHOP expression suggesting ER-stress associated cell death mechanisms This compound is utilized in neuroscience and cell biology research to investigate ubiquitin pathway modulation and related cellular responses
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | 568-72-9 | MFCD00238692 | 20MG
Tanshinone IIA United States Pharmacopeia (USP) Reference Standard | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 20MG
Selleck Chemical LLC Nab-Paclitaxel-E1068-100MG
Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1 9 It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system Solutions are unstable and should be fresh-prepared
Medchemexpress LLC Tanshinone IIA sulfonate sodium | 69659-80-9 | 396.39 | 5 MG
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA. It acts as an inhibitor of store-operated Ca2+ entry (SOCE) and is used to treat cardiovascular disorders. This product is for research use only and not sold to patients.
- Inhibits store-operated Ca2+ entry (SOCE)
- Used to treat cardiovascular disorders
- Inhibits hypoxia-induced PKG and PPAR-γ downregulation
- Suppresses TRPC1 and TRPC6 expression in hypoxic PASMCs
- Inhibits CYP3A4 activity
- Attenuates scopolamine-induced cognitive dysfunctions
- Alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model
- Prevents peritoneal adhesion
Medchemexpress LLC Cucurbitacin IIa | 58546-34-2 | 562.73 | 1 MG
Cucurbitacin IIa, also known as Hemslecin A, is an orally active EGFR inhibitor capable of permeating the blood-brain barrier. It demonstrates an IC50 of 1.455 nM against human EGFR and exhibits anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway.
Features and Benefits:
- Induces caspase-3-dependent apoptosis.
- Downregulates survivin expression.
- Enhances autophagy levels.
- Disrupts the actin cytoskeleton via actin aggregation.
- Arrests the cell cycle at the G2/M phase.
- Supports research into inflammation-related diseases.
- Useful in studies on depression and cancers like non-small cell lung cancer.
Abcam Paclita x el, Anticancer agent, 10MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LDN-57444, UCH-L1 inhibitor, 5MG
MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement