Diterpenoids
Cayman Chemical -AphIdIcolIn 25mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
Abcam Paclita x el, Anticancer agent, 10MG
MW 853.9 Da, Purity >98%. Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
TARGETMOL CHEMICALS INC Docetaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 uM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity. Purity 99.1%
Apexbio Technology LLC Resiniferatoxin 1mg
Resiniferatoxin (CAS 57444-62-9) is a potent selective agonist of the transient receptor potential vanilloid 1 (TRPV1) channel derived from plant sources By activating TRPV1 it induces sustained calcium influx in TRPV1-expressing sensory neurons leading to their desensitization or ablation In animal studies resiniferatoxin has been shown to induce long-lasting elimination of TRPV1-positive primary sensory afferents and blunt associated neural reflexes including those mediating cardiac sympathetic input Resiniferatoxin is widely used in research to investigate pain pathways sensory neuron function and neurogenic inflammation
Medchemexpress LLC Nab-Paclitaxel 25mg | 25mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Medchemexpress LLC (5E,9E,13E)-teprenone | 3796-63-2 | 99.9% | 330.56 g/mol | C23H38O | 10 MG
(5E,9E,13E)-teprenone is a geranylgeranyl-derived small molecule used in research to induce heat shock proteins (HSPs) and to study gastric mucosal protection. Supplied as a high-purity reagent suitable for biochemical and cellular assays.
- High purity (99.9%) suitable for research applications.
- CAS number 3796-63-2 for unambiguous identification.
- Chemical formula C23H38O; molecular weight 330.56 g/mol.
- Supplied as a 10 mg pack for small-scale experiments.
- Recommended storage: 4°C; in solvent: -80°C (6 months) or -20°C (1 month) under nitrogen.
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 1 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. It eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period.
- Purity of 99.77%
- Molecular weight: 628.71
- Chemical formula: C37H40O9
- Appearance: Solid
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity in TRPV1-positive pain fibers or cell bodies
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 500 UG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules as tracers for quantitation during the drug development process.