Tartaric Acid
Apexbio Technology LLC ENMD-2076 934353-76-1 5mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Apexbio Technology LLC ENMD-2076 934353-76-1 200mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Apexbio Technology LLC ENMD-2076 934353-76-1 50mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Apexbio Technology LLC ENMD-2076 934353-76-1 10mg
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 1 MG
ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 1 MG
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 100 MG
ENMD-2076 is a multi-targeted kinase inhibitor with high selectivity towards Aurora A versus Aurora B. It inhibits HUVEC growth and shows antiproliferative effects on human leukemia cell lines. This compound induces G2-M-phase arrest and apoptosis in U937 cells and inhibits Flt3 and Kit autophosphorylation. In vivo, ENMD-2076 demonstrates dose-dependent inhibition of tumor growth and is well tolerated in animal studies.
- Multi-targeted kinase inhibitor.
- Inhibits HUVEC growth.
- Shows antiproliferative effects on leukemia cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Results in dose-dependent inhibition of tumor growth in vivo.
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 10 MG
ENMD-2076 is a multi-targeted kinase inhibitor, demonstrating significant activity against Aurora A, Flt3, KDR/VEGFR2, and other kinases. It effectively inhibits cellular autophosphorylation and induces G2-M-phase arrest and apoptosis in various cell lines. In vivo studies show dose-dependent inhibition of tumor growth and tumor regression, with the compound being well tolerated.
- Inhibits multiple kinases including Aurora A, Flt3, VEGFR2
- Induces G2-M-phase arrest and apoptosis
- Demonstrates antiproliferative activity against human cell lines
- Inhibits cellular Flt3 ligand (FL)-induced Flt3 autophosphorylation
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation
- Inhibits VEGFR2/KDR autophosphorylation
- Leads to dose-dependent inhibition of tumor growth in vivo
Apexbio Technology LLC ENMD-2076 934353-76-1 10mM (in 1mL DMSO)
ENMD-2076 (CAS 934353-76-1) is a selective inhibitor of Aurora A kinase (IC50 14 nM) and FLT3 (IC50 1 86 nM) with additional inhibitory activity against multiple tyrosine kinases implicated in angiogenesis and cell proliferation including RET FLT4/VEGFR3 SRC CSF1R NTRK1 FGFR1/2 VEGFR2/KDR LCK and PDGFR (IC50 1 86 120 nM) ENMD-2076 disrupts cell cycle progression by arresting cells in the G2/M phase through inhibition of Aurora kinases suppresses the PI3K/AKT signaling pathway and demonstrates cytotoxic effects in hematologic malignancy and solid tumor cell lines (in vitro IC50 25 700 nM) In vivo it reduces tumor growth and angiogenesis in xenograft models supporting its use in cancer research and antiangiogenic studies
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 50 MG
ENMD-2076 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. It is for research use only and not sold to patients.
- Multi-targeted kinase inhibitor
- Orally active
- Antiangiogenic and antiproliferative mechanisms of action
Medchemexpress LLC 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine | 934353-76-1 | MFCD16619371 | 100.0% | 375.47 | 10 MG
ENMD-2076 is a multi-targeted kinase inhibitor that selectively binds to and inhibits tyrosine and Aurora kinases. This action can lead to the inhibition of cell division and proliferation, and may induce apoptosis in tumor cells. It also exhibits antiangiogenic activity, making it suitable for various research applications.
- Inhibits multiple kinases including Aurora A, Flt3, KDR/VEGFR2, and FGFR1.
- Demonstrates antiproliferative activity against human cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Shows dose-dependent inhibition of tumor growth in vivo.
Medchemexpress LLC Fostamatinib (disodium hexahydrate) | 914295-16-2 | 99.5% | 25 MG
Fostamatinib (disodium hexahydrate) is a laboratory chemical provided as a solid with a purity of 99.5%. It requires sealed storage at 4°C away from moisture. When in solvent, it can be stored at -80°C for 6 months or -20°C for 1 month.
- Stable under recommended storage conditions
- Requires sealed storage to protect from moisture
- Recommended storage at 4°C
- For solutions, store at -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC Prednisolone disodium phosphate | 125-02-0 | 99.5% | 500 MG
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It can be rapidly and completely hydrolyzed to Prednisolone in the plasma.
- Synthetic glucocorticoid
- Anti-inflammatory and immunomodulating properties
- Rapidly and completely hydrolyzed to Prednisolone in plasma
- Store at 4°C, sealed, away from moisture (solid)
- Store in solvent at -80°C (6 months) or -20°C (1 month)
- Soluble in H2O at 50 mg/mL with ultrasonic
- For research use only
Medchemexpress LLC Prednisolone disodium phosphate | 125-02-0 | MFCD00083682 | 99.50% | 25 MG
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It is rapidly and completely hydrolyzed into prednisolone in the plasma. This product is intended for research use only.
- Synthetic glucocorticoid
- Possesses anti-inflammatory properties
- Has immunomodulating properties
- Rapidly and completely hydrolyzed into prednisolone in plasma
- White to off-white solid appearance
- Molecular weight of 484.39
- Chemical formula C21H27Na2O8P
- Recommended storage at 4°C, sealed and away from moisture
- In solution, can be stored at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC R,S-anatabine | 2743-90-0 | MFCD01669938 | 99.7% | 160.22 | C10H12N2 | 100MG
(R,S)-Anatabine is the racemic form of anatabine, a minor tobacco alkaloid supplied as an analytical standard and research reagent for biochemical and analytical applications, including use as a marker of tobacco exposure and in amyloid-beta studies.
- Analytical standard for detection and quantification of tobacco alkaloids.
- Racemic (R,S) form of anatabine.
- Molecular formula C10H12N2; molecular weight 160.22.
- High purity (99.7%).
- Typically supplied as a 100 mg reference material.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC D-(-)-tartaric acid diisopropyl ester | 62961-64-2 | MFCD00008876 | 234.25 g/mol | C10H18O6 | 100 G
D-(-)-Tartaric acid diisopropyl ester is a chiral organic reagent used as a chemical building block and biochemical reagent in life-science research. It is the diisopropyl ester derivative of D-tartaric acid and is supplied for use in synthesis, enantioselective transformations, and analytical applications.
- Chiral diisopropyl ester of D-tartaric acid for enantioselective synthesis.
- Suitable as a reagent and building block in organic synthesis and biochemical assays.
- Molecular formula C10H18O6; molecular weight 234.25 g/mol.
- Available in multiple package sizes from 10 g to 500 g.
- Storage recommendations: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).
- Product documentation includes a data sheet and safety data sheet.