Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Mp6 (TFA) | 98.5% | 5 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide and an integrin β3 inhibitor. It prevents the interaction of Gα13 with integrin β3 while preserving talin-dependent integrin function. This peptide also blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Inhibits Gα13-integrin β3 interaction
- Preserves talin-dependent integrin function
- Blocks GTP usage of Rac1, Rap1, and Rab7
- Inhibits infection of CHO-A24 cells
- For research use only
Medchemexpress LLC Spinorphin (TFA) | 2828433-21-0 | 99.4% | 991.06 | 5 MG
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. It inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme, and enkephalinase. Spinorphin also has an antinociceptive effect.
- For research use only
Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.
- Selective Wnt signaling inhibitor.
- Cell-permeable.
- Stapled peptide.
- Inhibits β-catenin-transcription factor interactions.
- Shows anti-proliferation of cancer cells.
- Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
- Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).
Medchemexpress LLC MS15 TFA | C66H80F3N11O7S | 1 MG
MS15 TFA is a potent and selective PROTAC (proteolysis-targeting chimera) degrader that targets AKT. It effectively inhibits the activity of all three AKT isoforms (AKT1, AKT2, and AKT3) with varying potencies. This compound is suitable for research applications to study AKT's role in cellular processes.
- It is a potent and selective AKT PROTAC degrader.
- It inhibits AKT1 activity with an IC50 of 798 nM.
- It inhibits AKT2 activity with an IC50 of 90 nM.
- It inhibits AKT3 activity with an IC50 of 544 nM.
- It is bioavailable in mice through intraperitoneal administration.
- It is supplied as a solid with a white to yellow appearance.
- It is soluble in DMSO at concentrations of 100 mg/mL or higher.
Medchemexpress LLC mP6 (TFA) | 2700321-79-3 | 990.15 | 1 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide that functions as an Integrin β(3) Inhibitor. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. Additionally, mP6 blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Functions as an Integrin β(3) Inhibitor
- Inhibits the interaction of Gα13 with integrin β3
- Does not disrupt talin-dependent integrin function
- Blocks the GTP usage of Rac1, Rap1, and Rab7
- Effectively inhibits the infection of CHO-A24 cells
Medchemexpress LLC DPC-AJ1951 TFA | 99.4% | 1666.99 (free base) | 5 MG
This 14 amino acid peptide acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption.
- Potent agonist of parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo bone resorption assays
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with human PPR
Medchemexpress LLC TfR-T12 TFA | 99.1% | 1604.75 | 1 MG
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide. It binds to the TfR and is subsequently internalized into TfR-expressing cells, making it suitable for research applications.
- Displays a binding affinity in the nM range.
- Synthetic peptide obtained by phage display.
- Binds to a different site on TfRs compared with transferrin.
- Can be chemically conjugated to construct multifunctional lipid vesicles.
Medchemexpress LLC Cyclo(RLsKDK) TFA | 99.7% | 841.88 | 1 MG
Cyclo(RLsKDK) TFA is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. It is utilized in research for inflammatory diseases and cancer studies.
- Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
- Promotes ADAM8 activation and CD23 shedding (IC50 120 nM and 182 nM).
- Increases activity of pro-ADAM8.
- Reduces tumor load and improves survival rates in pancreatic ductal adenocarcinoma (PDAC) mice models.
- Reduces sADAM8 content, pERK1/2 activation, and PDAC metastasis in vivo.
Medchemexpress LLC Adrixetinib (TFA) | 2394874-66-7 | C27H25F6N5O7 | 1 ML
Adrixetinib (TFA) is a protein tyrosine kinase (PTK) inhibitor (antagonist) with anti-tumor effects.
- Molecular formula: C27H25F6N5O7.
- Molecular weight: 645.51.
- Appearance: Off-white to light yellow solid.
- Purity (HPLC) of 99.82%.
- Recommended storage at 4°C in sealed conditions, away from moisture.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month, under sealed conditions and away from moisture.
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Llvk tfa | 585.66 | 5 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), making it promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 (free base) | 25 MG
MPSD TFA is the TFA salt form of MPSD. It is a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). This peptide has the ability to sense membrane curvature and recognize phosphatidylserine. It can be used as a biological probe to investigate membrane shape and lipid composition.
- 25-amino acid peptide based on the MARCKS effector domain.
- Senses membrane curvature.
- Recognizes phosphatidylserine.
- Utilized as a biological probe to study membrane shape and lipid composition.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 4X100G
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 4X100G
