Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC DX600 TFA | 99.2% | 3074.33 (free acid) | 1 MG
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been observed to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity. It is for research use only.
- Selective ACE2 specific inhibitor
- Does not cross-react with ACE
- Exacerbates diabetes-induced cardiovascular dysfunction
- Increases cardiac and renal NOX activity
Medchemexpress LLC EZM0414 (TFA) | 2411759-92-5 | 95.48% | 514.51 | 50 MG
EZM0414 TFA is the trifluoroacetic acid salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, researched for relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent and selective SETD2 inhibitor
- Orally active
- Inhibits proliferation of MM and DLBCL cell lines
- Shows robust tumor growth regressions in xenograft models
- High oral bioavailability in rats and mice
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
Medchemexpress LLC Cyclo(RGDyC) TFA | 95.68% | 594.64 | 1 MG
Cyclo(RGDyC) TFA is a cyclic pentapeptide with anti-angiogenic abilities. It can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer.
- Cyclic pentapeptide
- Anti-angiogenic abilities
- Contains the alphaVbeta3 integrin-binding sequence arginine-glycine-aspartate (RGD)
- Can be used to target tumors and ocular neovasculature
- White to off-white solid appearance
- Soluble in H2O
Medchemexpress LLC HR97 TFA | 1518.84 | 5 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Molecular weight of 1518.84 (free acid)
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Solubility in DMSO: 50 mg/mL (requires ultrasonic)
- Can be used to prepare HR97-SunitiGel eye drops
Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.
- Selective Wnt signaling inhibitor.
- Cell-permeable.
- Stapled peptide.
- Inhibits β-catenin-transcription factor interactions.
- Shows anti-proliferation of cancer cells.
- Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
- Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections
Medchemexpress LLC Charybdotoxin TFA | 96.8% | 4295.89 (free acid) | 100 UG
Charybdotoxin TFA is a 37-amino acid peptide that functions as a potassium channel blocker. This compound is a valuable tool for research involving potassium channels.
- Acts as a potassium channel blocker
- 37-amino acid peptide
- Useful for studying potassium channels
- Storage conditions for powder: -80°C for 2 years, -20°C for 1 year
- Storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month
- Sealed storage, away from moisture and light required for both forms
Medchemexpress LLC GsMTx4 TFA | 99.9% | 4095.84 | 1 MG
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs) and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity, making it a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels (MSCs)
- Blocks cation-selective stretch-activated channels (SACs)
- Attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity
- Attenuates microglial reactivity
- Useful as a pharmacological tool for identifying the role of excitatory mechanosensitive channels
Medchemexpress LLC (S)-2-Amino-6-(2-(2-azidoacetamido)acetamido)hexanoic acid (TFA) | 99.77% | 400.31 | 25 MG
AzGGK TFA is an unnatural amino acid that can be site-specifically incorporated into proteins through genetic-code expansion. It serves as a site-specific probe for ubiquitylation and SUMOylation. As a click chemistry reagent, AzGGK TFA contains an Azide group, enabling it to undergo various cycloaddition reactions.
- Unnatural amino acid
- Site-specifically incorporated into proteins via genetic-code expansion
- Serves as a site-specific probe for ubiquitylation and SUMOylation
- Click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 (free base) | 5 MG
Pep42 TFA is a cyclic peptide ligand that targets GPR78. It has the ability to selectively internalize into highly metastatic human melanoma cells through a receptor-mediated process.
- Intended for research purposes; not for sale to patients
- Internalizes specifically into highly metastatic human melanoma cells
- Operates via a receptor-mediated process
- It is a cyclic peptide ligand
- Solid, white to off-white appearance
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 25 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue. It acts as a GnRH receptor agonist.
- Luteinizing-hormone-releasing hormone (LHRH) analogue
- GnRH receptor agonist
Medchemexpress LLC Biotin-COG1410 TFA | 98.0% | 1 MG
Biotin-COG1410 TFA is a biotin-labeled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. It exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and can be used for the research of neurological diseases.
- Decreases the production and release of NO and TNFα in BV2 microglia cells.
- Exhibits significant improvement on vestibulomotor function and spatial learning and memory in mice.
- Improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats.
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 5 MG
Veldoreotide TFA (DG3173) is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and has potential use as a pain modulating agent.
- Activates somatostatin receptors 2, 4, and 5
- Inhibits growth hormone (GH) secretion in adenomas
- May be used as a pain-modulating agent
- Stimulates SST2, SST4, and SST5 receptors in HEK293 cells co-expressing these receptors with GIRK2 channels
- Inhibits SST4-expressing BON-1 cells at 10 μM for 24 hours
Supply Solutions Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml
Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml