Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC D2A21 TFA | 95.6% | 2775.42 | 5 MG
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and a bactericidal effect on burn scabs. It also exhibits antitumor activity and can be used in prostate cancer research.
- Antimicrobial peptide with significant antimicrobial activity against Pseudomonas
- Bactericidal effect on burn scabs
- Has antitumor activity
- Can be used in prostate cancer research
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.87% | 805.80 | 25 MG
RS 09 TFA is an LPS peptide mimic and a TLR4 agonist. It binds to TLR-4, activating NF-κB, and functions as an adjuvant in vivo to enhance the antigen-specific immune response.
- Acts as an LPS peptide mimic and TLR4 agonist.
- Binds to TLR-4 and activates NF-κB.
- Enhances antigen-specific immune response in vivo.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells.
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC T7 Tag Peptide TFA | 245445-88-9 | 98.7% | 1098.27 | 5 MG
T7 Tag Peptide is a protein tag composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. This peptide can be fused to the N-terminus or C-terminus of proteins, such as enhanced green fluorescent protein (EGFP), and is utilized in various immunoassays and affinity purification processes.
- Composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10
- Can be fused to the N-terminus or C-terminus of proteins
- Useful in various immunoassays
- Aids in affinity purification processes
Medchemexpress LLC Vu0364572 TFA | 1240514-89-9 | MFCD31618417 | 99.3% | 487.51 g/mol | C23H32F3N3O5 | 5 MG
VU0364572 TFA is the trifluoroacetate salt of a selective M1 muscarinic receptor agonist intended for use in in vitro and in vivo pharmacology research. It is supplied as a high-purity solid powder for laboratory research applications.
- High purity (99.3%) suitable for research use.
- Trifluoroacetate salt form to aid solubility and handling.
- Solid powder form for convenient weighing and formulation.
- Available in small pack sizes appropriate for discovery and preclinical studies.
- Recommended sealed storage away from moisture and light; follow solvent storage guidelines for long-term stability.
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 (free base) | 25 MG
MPSD TFA is the TFA salt form of MPSD. It is a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). This peptide has the ability to sense membrane curvature and recognize phosphatidylserine. It can be used as a biological probe to investigate membrane shape and lipid composition.
- 25-amino acid peptide based on the MARCKS effector domain.
- Senses membrane curvature.
- Recognizes phosphatidylserine.
- Utilized as a biological probe to study membrane shape and lipid composition.
Medchemexpress LLC FTO-IN-1 TFA | 2797619-81-7 | 98.1% | 505.27 | 1 ML
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32. It can be used for the research of cancer and is for research use only.
- FTO inhibitor with an IC50 of <1 μM
- Inhibits FTO enzyme activity by 62% in vitro at 50 μM
- Inhibits the viability of SCLC-21H, RH30 and KP3 cells with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively
Medchemexpress LLC C-telopeptide TFA | 868.89 (free base) | 25 MG
C-telopeptide TFA is a cross-linked peptide of type I collagen. It is released during bone resorption and has been correlated with bone mineral density (BMD). This product is intended for research use only.
- Cross-linked peptide of type I collagen
- Released during bone resorption
- Correlated with bone mineral density (BMD)
- Sequence: Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
- Target: MMP
- Pathway: Metabolic Enzyme/Protease
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.5% | 2759.12 | 25 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide that acts as a potent activator of STAT3, suppressing neuronal death in vitro. It demonstrates long-term beneficial effects against neurotoxicity, amyloid-beta (Aβ) deposition, neuronal apoptosis, and deficits in synaptic plasticity associated with neurodegenerative diseases. This compound holds potential for the treatment of Alzheimer's disease and ischemic brain injury.
- Neuroprotective properties
- Potent activator of STAT3
- Suppresses neuronal death
- Exhibits long-term beneficial effects against neurotoxicity
- Reduces amyloid-beta (Aβ) deposition
- Prevents neuronal apoptosis
- Addresses synaptic plasticity deficits
- Potential treatment for Alzheimer's disease
- Potential treatment for ischemic brain injury
Medchemexpress LLC Substance P TFA (neurokinin P TFA) | 148470-19-3 | 99.3% | 1461.65 | 25 MG
Substance P TFA (neurokinin P TFA) is a CNS-penetrant neuropeptide that functions as a neurotransmitter and neuromodulator within the central nervous system. Its endogenous receptor is the neurokinin 1 receptor (NK1-receptor, NK1R), playing a crucial role in various biological activities.
- Acts as a CNS-penetrant neuropeptide
- Functions as a neurotransmitter and neuromodulator
- Endogenous receptor is neurokinin 1 receptor (NK1R)
- Appears as a white to off-white solid
- Soluble in H2O and PBS with ultrasonic assistance
- Involved in the internalization and recycling of the NK1R complex
- Related to peptides, hormones, and neuropeptides classifications
- Associated with research in cancer, neurological, and metabolic diseases
Medchemexpress LLC Galantide (TFA) | 98.1% | 2313.55 | 500 UG
Galantide TFA is a synthetic peptide known to act as a galanin receptor antagonist. It is provided in a high purity powder form, suitable for various laboratory applications.
- High purity powder
- Acts as a galanin receptor antagonist
- Suitable for laboratory research
Medchemexpress LLC VTP-27999 (TFA) | 1013937-63-7 | 97.0% | C28H42ClF3N4O7 | 5 MG
VTP-27999 (TFA) is an alkyl amine Renin inhibitor useful for hypertension and end-organ diseases. This product is for research use only.
- Alkyl amine Renin inhibitor
- Useful for hypertension research
- Useful for end-organ diseases research
- For research use only
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 25 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. It inhibits the proliferation of NSCLC cells and can be used for anticancer research. MS9427 TFA has antiproliferative activity against HCC-827 cells, potently inducing EGFRDel19 degradation and inhibiting EGFR phosphorylation.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Functions through ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways
- Inhibits proliferation of NSCLC cells
- Supports anticancer research
- Displays antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
- Inhibits EGFR phosphorylation
Medchemexpress LLC MM-401 (TFA) | 1442106-11-7 | 99.3% | 700.75 | 5 MG
MM-401 (TFA) is an inhibitor of MLL1 H3K4 methyltransferase. It works by blocking the interaction between MLL1 and WDR5, thereby inhibiting MLL1 activity with an IC50 of 0.32 μM. This compound can induce cell cycle arrest, apoptosis, and differentiation. It is used in research for MLL leukemia.
- Inhibits MLL1 H3K4 methyltransferase
- Blocks MLL1-WDR5 interaction
- Potent inhibition of MLL1 activity
- Induces cell cycle arrest
- Promotes apoptosis
- Facilitates differentiation
- Useful for research of MLL leukemia
- Specifically inhibits MLL1-dependent H3K4 methylation in cells
- Inhibits growth of MLL leukemia cells
- Affects MLL-AF9 transcriptome