Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cpn-351 TFA | 912.11 (free base) | 1 MG
CPN-351 TFA (compound 9a) is a pentapeptide that acts as a selective antagonist of human NMUR1. Its antagonistic effect on human NMUR1 is 10 times higher than on NMUR2, making it useful in the study of inflammation.
- Selective antagonist of human NMUR1
- Antagonistic effect is 10 times higher on NMUR1 than NMUR2
- Can be used in the study of inflammation
- pA2 of 7.35 for NMUR1
- Kb of 45 nM for NMUR1
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 10MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, functioning as a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. It induces mitochondrial alterations, reactive oxygen species generation, and intracellular calcium accumulation, leading to calcium-dependent cell death in breast cancer cells. This compound also activates the immune system in breast cancer cells via immunogenic cell death.
- Conjugated peptide acting as a CD47 agonist
- Thrombospondin-1 peptide mimic
- Exhibits antitumor effects
- Induces mitochondrial alterations
- Promotes reactive oxygen species (ROS) generation
- Causes intracellular calcium (Ca+) accumulation
- Leads to calcium-dependent cell death in breast cancer cells
- Activates the immune system through immunogenic cell death
Medchemexpress LLC Ribupatide TFA | 2940971-65-1 | 99.8% | 4907.48 | 1 MG
Ribupatide TFA is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. It is orally active and can also be administered by injection, making it suitable for antidiabetic research.
- Dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist
- Can be studied in antidiabetic research
- Orally active
- Can also be administered by injection
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC D2A21 TFA | 95.6% | 2775.42 | 5 MG
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and a bactericidal effect on burn scabs. It also exhibits antitumor activity and can be used in prostate cancer research.
- Antimicrobial peptide with significant antimicrobial activity against Pseudomonas
- Bactericidal effect on burn scabs
- Has antitumor activity
- Can be used in prostate cancer research
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.87% | 805.80 | 25 MG
RS 09 TFA is an LPS peptide mimic and a TLR4 agonist. It binds to TLR-4, activating NF-κB, and functions as an adjuvant in vivo to enhance the antigen-specific immune response.
- Acts as an LPS peptide mimic and TLR4 agonist.
- Binds to TLR-4 and activates NF-κB.
- Enhances antigen-specific immune response in vivo.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells.
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
Medchemexpress LLC Stressin I TFA | 98.63% | 4472.20 (free base) | 1 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent and selective agonist for the CRF1 receptor, intended for research use only. It has been shown to increase adrenocorticotropic hormone (ACTH) levels in rats.
- Potent CRF1 receptor selective agonist
- Ki of 1.7 nM
- Increases adrenocorticotropic hormone (ACTH) levels in rats
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 74838-83-8 | 98.6% | 367.32 | 5 MG
Cyclo(Arg-Pro) TFA is a chitinase inhibitor that disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. It prevents cell separation of *Saccharomyces cerevisiae*, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Additionally, it blocks the morphological transition of *Candida albicans* from yeast form to hyphal form, without inhibiting cell growth.
- Disrupts cell separation and morphological transition of yeast
- Prevents cell separation of *Saccharomyces cerevisiae*
- Leads to formation of grape-like cell clusters
- Blocks morphological transition of *Candida albicans* from yeast form to hyphal form
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 5 MG
Veldoreotide TFA (DG3173) is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and has potential use as a pain modulating agent.
- Activates somatostatin receptors 2, 4, and 5
- Inhibits growth hormone (GH) secretion in adenomas
- May be used as a pain-modulating agent
- Stimulates SST2, SST4, and SST5 receptors in HEK293 cells co-expressing these receptors with GIRK2 channels
- Inhibits SST4-expressing BON-1 cells at 10 μM for 24 hours
Medchemexpress LLC T7 Tag Peptide TFA | 245445-88-9 | 98.7% | 1098.27 | 5 MG
T7 Tag Peptide is a protein tag composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. This peptide can be fused to the N-terminus or C-terminus of proteins, such as enhanced green fluorescent protein (EGFP), and is utilized in various immunoassays and affinity purification processes.
- Composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10
- Can be fused to the N-terminus or C-terminus of proteins
- Useful in various immunoassays
- Aids in affinity purification processes
Medchemexpress LLC Iberiotoxin (TFA) | 4230.85 | 500 UG
Iberiotoxin (TFA) is a selective high conductance Ca2+-activated K+ channel inhibitor with a Kd of approximately 1 nM. It does not block other types of voltage-dependent ion channels.
- Selective high conductance Ca2+-activated K+ channel inhibitor
- Kd of approximately 1 nM
- Does not block other types of voltage-dependent ion channels
Medchemexpress LLC Siivfekl (Tfa) | 99.85% | 948.16 | 1 MG
SIIVFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It is designed to stimulate specific T cells in experimental settings to study the competitive interaction between T cells. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for the detection of CD8+ T cells.
- Variant of the major MHC class I-restricted epitope SIINFEKL
- Stimulates specific T cells for competitive interaction studies
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Suitable for detection of CD8+ T cells
- High purity of 99.85%
- Provided as a white to off-white solid
- Stable under recommended storage conditions