Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TL033 | 2356230-22-1 | 1630.83 | 25 MG
TL033 is a chemical substance identified for laboratory use, including the manufacture of other substances. It is supplied as a solid and is intended for research purposes only by experienced personnel.
- Identified for laboratory chemical manufacturing
- Supplied as a solid
- Recommended storage at -20°C, protected from light
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 1 MG
DV1 TFA is a selective antagonist of CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry through the CXCR4 co-receptor
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC PBP10 TFA | 98.2% | 1826.07 | 1 MG
PBP10 is a cell-permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. This 10-AA peptide, with rhodamine conjugated at its N-terminus, exhibits bactericidal activity against gram-positive and gram-negative bacteria and mitigates microbial-induced inflammatory effects.
- Cell-permeable
- Selective gelsolin-derived peptide inhibitor of FPR2 over FPR1
- 10-AA peptide with rhodamine conjugated at its N-terminus
- Exerts bactericidal activity against gram-positive and gram-negative bacteria
- Limits microbial-induced inflammatory effects
Medchemexpress LLC Gln-AMS TFA | 99.85% | 588.47 | 50 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It specifically inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. This product is intended for research use only.
- Inhibits glutaminyl-tRNA synthetase.
- High purity of 99.85%.
- Available in various quantities.
- Data sheet, COA, SDS, and handling instructions provided.
- Supported by customer reviews and publications.
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility
Medchemexpress LLC OncoACP3 TFA | 3084147-81-6 | 1323.35 | 5 MG
OncoACP3 TFA | 3084147-81-6 | 1323.35 | 5 MG
Medchemexpress LLC Balixafortide TFA | 99.89% | 1978.16 | 50 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. It shows 1000-fold selectivity for CXCR4 compared to a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. It is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent and exhibits anti-cancer effects.
- Potent, selective, well-tolerated peptidic CXCR4 antagonist
- High selectivity for CXCR4 (1000-fold over CXCR7)
- Blocks β-arrestin recruitment and calcium flux
- Potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Anti-cancer effects
- Optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability
Medchemexpress LLC LARLLT (TFA) | 99.9% | 799.88 | 5 MG
LARLLT (TFA) is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers, including lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research of EGFR overexpressing cancers
- Targets EGFR
- Involves JAK/STAT signaling and protein tyrosine kinase/RTK pathways
- Sequence: Leu-Ala-Arg-Leu-Leu-Thr
- Molecular weight of 799.88
- Purity of 99.9% (HPLC)
- Soluble in DMSO: 50 mg/mL
- Appears as a white to off-white solid
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC WP9QY (TFA) | 98.7% | 1340.40 | 500 UG
WP9QY TFA is a biologically active cyclic peptide that acts as a TNF-α antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, thereby preventing interactions between TNF and its receptor. This TNF antagonist serves as a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. This product is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics TNF recognition loop on TNF receptor I
- Prevents interactions of TNF with its receptor
- Useful for developing small molecular inhibitors
- Prevents inflammatory bone destruction in rheumatoid arthritis
- Prevents systemic bone loss in rheumatoid arthritis
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Difopein TFA | 96.30% | 6387.17 (free acid) | 5 MG
Difopein TFA is a specific and competitive inhibitor of the 14-3-3 protein, a highly conserved eukaryotic regulatory molecule. It functions by blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. This compound is not cell permeable and induces apoptosis, enhancing the ability of Cisplatin to kill cells.
- Specific and competitive inhibitor of 14-3-3 protein
- Blocks 14-3-3 from binding to target proteins
- Inhibits 14-3-3/ligand interactions
- Induces apoptosis
- Enhances cisplatin's ability to kill cells
- Target: 14-3-3 protein
- Soluble in DMSO at ≥ 100 mg/mL
- In vivo soluble at ≥ 2.5 mg/mL with specific protocol
- Recommended storage for powder: -80°C for 2 years; -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month