Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC Rsm3 Tfa | 98.8% | 3049.66 | 1 MG
This product is a stapled peptide that acts as an inhibitor of METTL3-METTL14, with a Kd of 3.10 μM. It has been shown to inhibit tumor growth and induce cell apoptosis, making it useful for cancer research.
- It is a stapled peptide.
- It is a METTL3-METTL14 inhibitor.
- It inhibits tumor growth.
- It induces cell apoptosis.
- It is suitable for cancer research.
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 5 MG
L2P4 TFA is a peptide-based and EBNA1 targeting fluorescent probe. It inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. L2P4 TFA exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based probe
- EBNA1 targeting
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells
- Suitable for cancer targeted therapy and immunotherapy research
- Used in peptide-drug conjugates research
Medchemexpress LLC Katacalcin TFA | 99.6% | 2550.62 | 25 MG
Katacalcin TFA (PDN 21 TFA) is a potent plasma calcium-lowering peptide from the calcitonin family. It rapidly decreases blood calcium and phosphate by promoting their incorporation into bones. It also deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis and regulates their migration.
- Potent plasma calcium-lowering peptide
- Belongs to the calcitonin family
- Promotes incorporation of calcium and phosphate into bones
- More potent inhibitor of fMLP-induced chemotaxis
- Deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis
- Regulates human CD14+ PBMC migration
Medchemexpress LLC CPP9 TFA | 99.9% | 1553.37 | 1 MG
CPP9 TFA is a small, amphipathic, cyclic cell penetrating peptide (CPP). CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome. It can be used for intracellular delivery of therapeutic agents and chemical probes.
- Small, amphipathic, cyclic cell penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficient release from the endosome
- Used for intracellular delivery of therapeutic agents
- Used for intracellular delivery of chemical probes
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
Medchemexpress LLC Tat-NR2B9c TFA | 1834571-04-8 | 99.7% | 2632.90 | 25 MG
Tat-NR2B9c TFA is a potent inhibitor of postsynaptic density-95 (PSD-95). It selectively disrupts the interaction between PSD-95 and NMDAR, inhibiting the binding of NR2A and NR2B to PSD-95. This compound also inhibits the interaction between neuronal nitric oxide synthase (nNOS) and PSD-95, demonstrating significant neuroprotective efficacy.
- Potent PSD-95 inhibitor with high affinity for PSD-95d2 (EC50 6.7 nM)
- Inhibits NMDAR2A, NMDAR2B, and NMDAR2C binding to PSD-95
- Blocks interaction between PSD-95 and nNOS
- Reduces infarction volume in vivo
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Medchemexpress LLC Iberiotoxin TFA | 99.4% | 4230.85 | 1 MG
Iberiotoxin (TFA) is a potent and selective inhibitor of high conductance Ca2+-activated K+ channels. This compound demonstrates high affinity for its target with a Kd of approximately 1 nM, and it specifically targets these channels without affecting other types of voltage-dependent ion channels.
- Selective inhibitor of high conductance Ca2+-activated K+ channels.
- High affinity with a Kd of ~1 nM.
- Does not block other types of voltage-dependent ion channels.
Medchemexpress LLC GRGDSP TFA | 98.0% | 701.61 | 25 MG
GRGDSP (TFA) is an integrin inhibitor. This synthetic linear RGD peptide can inhibit the adherence of tumor cells to endothelial cells of blood vessels, thereby limiting metastasis. It is also utilized to modify the surface of cardiovascular implants, such as vascular grafts, to promote endothelialization, and is widely employed in integrin research as a soluble integrin-blocking RGD-based peptide.
- Inhibits adherence of tumor cells to endothelial cells of blood vessels
- Limits metastasis
- Promotes endothelialization for cardiovascular implants
- Used in integrin research
- Functions as a soluble integrin-blocking RGD-based peptide
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 (free base) | 25 MG
FLAG peptide TFA is the TFA salt form of FLAG peptide. It is a multifunctional fusion tag used for the purification of recombinant proteins. It maintains the natural folding of its fusing proteins and can be removed by enterokinase, and eluted under non-denaturing conditions.
- Used as a multifunctional fusion tag
- Purifies recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC TAT peptide TFA | 99.8% | 1735.93 | 25 MG
TAT peptide (TFA) is a cell penetrating peptide (GRKKRRQRRRPQ) derived from the trans-activating transcriptional activator (Tat) from HIV-1. It has been studied in functionalized hybrid nanoparticles for magnetic enrichment and optical detection in cell separation and rapid cell labelling, demonstrating good biocompatibility.
- Derived from trans-activating transcriptional activator (Tat) from HIV-1
- Cell penetrating peptide (GRKKRRQRRRPQ)
- Used in functionalized hybrid nanoparticles for cell separation
- Used in rapid cell labelling
- Shows good biocompatibility
- For research use only
Medchemexpress LLC Lysylcysteine TFA | 97.8% | 477.38 | 25 MG
Lysylcysteine TFA (L-Lysyl-L-cysteine TFA) is a dipeptide composed of lysine and cysteine, intended for research use only. It is not for human use. This product is provided as a white to off-white solid with a high purity of 97.84% and a molecular weight of 477.38. It is shipped at room temperature in the continental US and requires sealed storage away from moisture.
- High purity: 97.84%
- Molecular weight: 477.38
- Dipeptide composed of lysine and cysteine
- Appearance: White to off-white solid
- Sequence: Lys-Cys
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC DV1 TFA | 98.53% | 2424.85 | 25 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor, making it suitable for research applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 25 MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects.
- Induces mitochondrial alterations
- ROS generation
- Intracellular Ca+ accumulation
- Calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells through immunogenic cell death