Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
Medchemexpress LLC Mambalgin 1 TFA | 95.7% | 6554.54 | 100 UG
Mambalgin 1 TFA is a selective ASIC1a inhibitor with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer. It binds to closed/inactive channels and exhibits selectivity for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2 channels. It has been shown to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests. This product is for research use only.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
- For research use only
Medchemexpress LLC AT-1002 TFA | 835872-35-0 | 99.5% | 821.91 | 1 ML
AT-1002 TFA, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer. It belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier.
- Can undergo Cys-Cys dimerization.
- Treatment for up to 3 hours did not affect Caco-2 cell viability at any concentration.
- Reduced cell viability after 24 hours at concentrations of 2.5 mg/mL and higher.
- Cells remained viable after 24 hours if washed after 3 hours exposure, indicating it does not irreversibly damage cells.
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
Medchemexpress LLC Saralasin TFA | 34273-10-4 | 99.18% | 1026.07 | 25 MG
Saralasin TFA, an octapeptide analog of angiotensin II, functions as a competitive angiotensin II receptor antagonist and exhibits partial agonist activity. It is utilized in the research of renovascular hypertension and renin-dependent (angiotensinogenic) hypertension.
- Competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM.
- Exhibits partial agonist activity.
- Inhibits cell growth in 3T3 and SV3T3 cells.
- Restores potassium currents in myocytes.
- Inhibits binding of FITC-Ang II to rat liver membrane preparation.
- Reduces ovulation rate and prostaglandin levels in vitro.
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis in rats.
- Increases serum renin activity in normal, conscious rats.
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 1 MG
Veldoreotide (DG3173) TFA is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and shows potential as a pain modulating agent. This product is for research use only.
- Binds to and activates SSTR 2, 4, and 5
- Inhibits growth hormone (GH) secretion
- Potential pain modulating agent
- Purity: 98.97%
- Appearance: White to off-white solid
- Soluble in H2O at 25 mg/mL (requires ultrasonic)
Medchemexpress LLC ADWX 1 TFA | 98.4% | 4071.85 | 1 MG
ADWX 1 TFA is a novel peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. It inhibits Kv1.3 channel activity to specifically suppress both initial calcium signaling and NF-κB activation. This compound has demonstrated the ability to ameliorate experimental autoimmune encephalomyelitis (EAE) in rat models and is useful for studying T cell-mediated autoimmune diseases.
- Potent and selective Kv1.3 inhibitor with an IC50 of 1.89 pM
- Inhibits Kv1.3 channel activity
- Suppresses initial calcium signaling and NF-κB activation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) in rat models
- Useful for studying T cell-mediated autoimmune diseases
Medchemexpress LLC RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
Medchemexpress LLC DOTA-ADIBO TFA | 1374865-01-6 | 99.1% | 776.76 g/mol | C36H43F3N6O10 | 5 MG
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator supplied as the trifluoroacetic acid salt. It enables biomolecule conjugation via strain-promoted, copper-free azide-alkyne cycloaddition and supports construction of fusion chelator systems for radiometal labeling and PET radiotracer synthesis. The compound is provided as a high-purity solid with DMSO solubility and requires protected, low-temperature storage.
- DOTA-derived bifunctional chelator for copper-free click conjugation.
- Facilitates radiometal labeling for PET radiotracer synthesis.
- High reported purity suitable for research applications.
- Soluble in DMSO (≈100 mg/mL); may require sonication.
- Store under nitrogen, protect from light, keep at low temperatures.
- Provided as a TFA salt to aid handling and stability.
Medchemexpress LLC DV1 TFA | 98.53% | 2424.85 | 25 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor, making it suitable for research applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests