Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules Ambeed / 2-Fluoro-6-methylpyridine / 5g / 552650211 / A211927 / / 407-22-7 / MFCD00041226 / 111.119 / C6H6FN
Ambeed / 2-Fluoro-6-methylpyridine / 5g / 552650211 / A211927 / / 407-22-7 / MFCD00041226 / 111.119 / C6H6FN
Medchemexpress LLC Lys-bradykinin TFA | 99.9% | 1188.38 g/mol | C56H85N17O12 · x C2HF3O2 | 50 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of Lys-Bradykinin (kallidin), a biologically active nonapeptide ligand for bradykinin/kallidin receptors. Supplied as a solid peptide powder for research use, it is commonly used in studies of vascular regulation, inflammation, and receptor pharmacology.
- Trifluoroacetate salt of Lys-Bradykinin (kallidin).
- Purity 99.85%.
- Molecular weight 1188.38 g/mol.
- Available as solid powder, including 50 MG size.
- Storage: powder -80°C for 2 years, -20°C for 1 year; in solvent -80°C for 6 months, -20°C for 1 month.
- Documentation includes COA, RP-HPLC, LCMS, elemental analysis, and SDS.
eMolecules Ambeed / 1-Bromo-4-(trifluoromethoxy)benzene / 1g / 490539162 / A229077 / / 407-14-7 / MFCD00040834 / 241.007 / C7H4BrF3O
Ambeed / 1-Bromo-4-(trifluoromethoxy)benzene / 1g / 490539162 / A229077 / / 407-14-7 / MFCD00040834 / 241.007 / C7H4BrF3O
Medchemexpress LLC Box5 (TFA) | 00-00-0 | 99.2% | 880.9 Da | C32H51F3N6O15S2.xC2HF3O2 | 5 MG
Box5 TFA is the trifluoroacetate salt form of a peptide antagonist of Wnt5a used in vitro to study Wnt5a-mediated signaling, calcium release, and cell migration. Supplied in small milligram vials, the material is provided with documentation to support research use.
- Trifluoroacetate salt form for improved solubility and handling.
- Potent antagonist of Wnt5a signaling for pathway studies.
- Inhibits Wnt5a-mediated calcium release and cell migration.
- High purity approximately 99.2% for consistent results.
- Supplied in small milligram sizes suitable for in vitro experiments.
- COA and SDS available for quality and safety verification.
Medchemexpress LLC L-lysyl-L-cysteine trifluoroacetate | 97.8% | 477.38 g/mol | C13H21F6N3O7S | 5 MG
L-lysyl-L-cysteine trifluoroacetate is a dipeptide formed from lysine and cysteine, provided as a solid TFA salt for research use. The material is characterized by a reported purity, defined molecular formula and molecular weight, and specified storage recommendations for powder and solutions.
- Dipeptide composed of lysine and cysteine.
- Supplied as trifluoroacetate (TFA) salt in solid powder form.
- Reported purity 97.8%.
- Molecular formula C13H21F6N3O7S and molecular weight 477.38 g/mol.
- Available in small research quantities: 5 mg, 10 mg, 25 mg.
- Store sealed, away from moisture; powder: -80°C for 2 years, -20°C for 1 year; in solvent: -80°C for 6 months, -20°C for 1 month.