Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC RVG TFA | 99.3% | 3266.62 | 5 MG
RVG TFA is a peptide derived from Rabies Virus Glycoprotein. It binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells and enhances the delivery of *Mycobacterium tuberculosis* antigens to antigen-presenting cells.
- Binds to α-7 subunit of nicotinic acetylcholine receptors
- Enhances delivery of *Mycobacterium tuberculosis* antigens
- Appears as a solid
- Color: white to off-white
- Soluble in water at ≥ 100 mg/mL
- For research use only
Medchemexpress LLC KS-133 (TFA) | 98.95% | 1672.93 | 1 MG
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.
- Highly selective and potent VIPR2 antagonist
- IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
- Reverses M2 to M1 macrophage phenotype
- Alters tumor immune microenvironment and inhibits tumor growth
- Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
- Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies
Medchemexpress LLC Gmprga Tfa | 98.1% | 5 MG
GMPRGA TFA is the trifluoroacetic acid (TFA) salt form of GMPRGA. It is known to recognize spAimR in the bacterial cytosol, a process that induces lysogeny.
- TFA salt form
- Recognizes spAimR in bacterial cytosol
- Induces lysogeny
- Functions as an inhibitor
- Part of bacterial lysis-lysogeny studies
- Classified as an antimicrobial peptide
Medchemexpress LLC Tcmcb07 tfa | 1456699-27-6 | 99.69% | 1344.5 g/mol | 1 MG
TCMCB07 TFA is a cyclic nonapeptide, recognized as an orally active and brain-penetrant antagonist of the melanocortin receptor 4 (MC4R). It is noted for its important role in cachexia and exhibits potential transport capabilities.
- Cyclic nonapeptide MC4R antagonist
- Orally active and brain-penetrant
- Important for cachexia research
- Exhibits potential transport capabilities
- Known to stimulate food intake and weight gain in rats
Medchemexpress LLC Kisspeptin 13 TFA | 98.9% | 1626.81 | 1 MG
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). It inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. This compound interacts with α2-adrenergic and 5-HT2 serotonin receptors and exhibits antidepressant efficacy. It is an activator for GPR54 and GnRH receptor, enhancing memory and being useful in Alzheimer's disease research.
- Inhibits glucose-induced insulin secretion (IC50 of 1.2 nM)
- Activates hypothalamic-pituitary-adrenal (HPA) axis
- Causes hyperthermia, motor behavior and anxiety in rats
- Interacts with α2-adrenergic and 5-HT2 serotonin receptors
- Exhibits antidepressant efficacy
- Activator for GPR54 and GnRH receptor
- Enhances memory
- Useful in Alzheimer's disease research
Medchemexpress LLC PF15 (TFA) | 99.7% | C46H50F3N13O8 | 25 MG
PF15 TFA is a PROTAC that connects ligands for FLT3 kinase and CRBN. It is a highly selective FLT3-ITD degrader with a DC50 of 76.7 nM. It significantly inhibits the proliferation of FLT3-ITD-positive cells and can down-regulate the phosphorylation of FLT3 and STAT5. It also inhibits tumor growth in mouse models and can be used in the study of leukemia.
- Connects ligands for FLT3 kinase and CRBN
- Highly selective FLT3-ITD degrader
- Has a DC50 of 76.7 nM
- Inhibits proliferation of FLT3-ITD-positive cells
- Down-regulates the phosphorylation of FLT3 and STAT5
- Inhibits tumor growth in mouse models
- Used in the study of leukemia
Medchemexpress LLC Glycyl-exatecan (TFA) | 1883333-57-0 | 96.9% | 100 MG
Glycyl-Exatecan TFA is a derivative of Exatecan, known for its significant antitumor activity. This compound acts as an anticancer agent and is suitable for research applications, particularly in studies involving solid tumors.
- Acts as an anticancer agent
- Exhibits significant antitumor activity
- Suitable for solid tumors research
- Derivative of Exatecan
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 25 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM. This compound demonstrates anti-tumor activity and is suitable for various research applications.
- Inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth.
- Inhibits TNK1-dependent L540 cell growth at low nM levels.
- Shows efficacy in mouse survival models, significantly prolonging lifespan.
- Inhibits localized tumor growth in mouse xenograft models.
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 50 MG
Glycyl-Exatecan TFA is a derivative of Exatecan and functions as an anticancer agent. It exhibits significant antitumor activity and can be utilized for research concerning cancers like solid tumors.
- Derivative of Exatecan
- Functions as an anticancer agent
- Exhibits significant antitumor activity
- Utilized in research concerning cancers like solid tumors
Medchemexpress LLC VU0364572 (TFA) | 1240514-89-9 | 99.3% | 487.51 | 25 MG
VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Neuroprotective potential for preventing memory impairments.
- Reduces neuropathology in Alzheimer's Disease.
- CNS penetrant.
Medchemexpress LLC Ac-devd-cmk tfa | 98.6% | 664.97 | 5 MG
Ac-DEVD-CMK TFA is a selective and irreversible caspase-3 inhibitor. It significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate, and can be used in various experimental approaches to inhibit apoptosis.
- Selective and irreversible caspase-3 inhibitor.
- Significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate.
- Suitable for various experimental approaches to inhibit apoptosis.
- Inhibits IDB-induced apoptosis.
- Attenuates acetaminophen-induced liver injury.
- Mitigates liver damage by inhibiting GSK‐3β or caspase‐3 activity.
- Effective in inhibiting citrate-induced p21 cleavage and G2/M accumulation in human pharyngeal squamous carcinoma cell lines.
Medchemexpress LLC Spexin (Neuropeptide Q) | 1370290-58-6 | 99.9% | 1619.88 | 1 MG
Spexin (Neuropeptide Q) | 1370290-58-6 | 99.9% | 1619.88 | 1 MG
Medchemexpress LLC RVD-Hpα TFA | 1431329-51-9 | 99.32% | 1538.67 | 1 MG
RVD-Hpα TFA is the N-terminally extended form of human hemopressin. It functions as a selective CB1 receptor agonist, increasing intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. It also acts as a high-affinity CB2 positive allosteric modulator.
- Acts as a selective CB1 receptor agonist
- Increases intracellular Ca2+ levels in CB1 receptor expressing cells
- Functions as a high-affinity CB2 positive allosteric modulator (Ki=50 nM)
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 5 MG
NN1177 TFA (NNC9204-1177 TFA) is a long-acting GLP-1/glucagon receptor co-agonist. This compound is known to induce dose-dependent body weight loss in diet-induced obese mice and improves glucose tolerance. It has also been shown to reduce liver fat and relevant inflammatory and fibrosis biomarkers in NASH models.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces body weight loss
- Improves glucose tolerance
- Reduces liver fat
- Reduces inflammatory and fibrosis relevant biomarkers
- For research use only
Medchemexpress LLC CL2A (TFA) | 2616704-22-2 | 99.5% | 1176.24 | C50H79N9O16 | 5 MG
CL2A (TFA) is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker for use in antibody-drug conjugate construction. The TFA salt form improves handling and stability and is designed to release payloads under acidic conditions to produce a bystander effect.
- Cleavable linker enabling payload release under acidic conditions.
- PEG8 spacer and triazole moiety for increased solubility and stability.
- Designed for conjugation to antibody cysteine residues via disulfide linkage.
- Available in small research-scale packages for use in ADC development.
- Stable as a powder when stored sealed at 4°C; shipped at room temperature.