Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Thymocartin TFA 25mg | 25MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g·mol⁻¹ | C34H49F3N4O10 | 25 MG
Alvespimycin trifluoroacetate (17-DMAG TFA) is the trifluoroacetic acid salt of a semisynthetic geldanamycin derivative that potently inhibits Hsp90. It binds Hsp90 in the low-nanomolar range and is used in cellular and biochemical studies to induce heat-shock response and promote degradation of Hsp90 client proteins, supporting research into proteostasis and targeted oncology pathways.
- Potent Hsp90 inhibition with reported EC50 ≈ 62 nM.
- Promotes Her2 degradation in cancer cell lines (EC50 8 nM in SKBR3, 46 nM in SKOV3).
- Induces Hsp70 expression in cell assays (EC50 4 nM in SKBR3, 14 nM in SKOV3).
- High purity (>98.9%) suitable for in vitro studies.
- Available in small research pack sizes, including 25 MG.
Medchemexpress LLC Frakefamide TFA 25mg | 25MG
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC AS-99 TFA | 99.1% | C29H31F6N5O5S2 | 1 MG
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50 of 0.79 μM, Kd of 0.89 μM) with anti-leukemic activity. It functions by blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo.
- Potent and selective ASH1L histone methyltransferase inhibitor
- Demonstrates anti-leukemic activity
- Blocks cell proliferation
- Induces apoptosis and differentiation
- Downregulates MLL fusion target genes
- Reduces leukemia burden in vivo
- Exhibits over 100-fold selectivity towards ASH1L over 20 other histone methyltransferases
- Suppresses MLL fusion driven transcriptional programs
- Leads to dose-dependent downregulation of canonical MLL fusion target genes
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 50 MG
Glycyl-Exatecan TFA is a derivative of Exatecan and functions as an anticancer agent. It exhibits significant antitumor activity and can be utilized for research concerning cancers like solid tumors.
- Derivative of Exatecan
- Functions as an anticancer agent
- Exhibits significant antitumor activity
- Utilized in research concerning cancers like solid tumors
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.5 | 5 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines. For research use only, not sold to patients.
- Peptide inhibitor of Grb7.
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM).
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Purity: 98.1%.
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC MPSD control peptide (TFA) | 99.8% | 3080.76 (free base) | 1 MG
MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD, a 25-amino acid peptide derived from the myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe capable of sensing membrane curvature and recognizing phosphatidylserine, making it useful for studying membrane shape and lipid composition.
- Derived from MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Useful for studying membrane shape and lipid composition
- Appears as a white to off-white solid
- High purity (99.8%)
- Molecular weight: 3080.76 (free base)
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.50 | 1 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Peptide inhibitor of Grb7
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM)
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines