Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC 6H05 trifluoroacetate | 2061344-88-3 | 99.0% | 590.14 | C22H31ClF3N3O4S3 | 1MG
6H05 TFA is the trifluoroacetate salt of 6H05, a selective, allosteric inhibitor of the oncogenic mutant K-Ras(G12C) intended for biochemical and cellular research. Supplied as a solid or as a 10 mM DMSO solution, the compound is provided at high purity for assay development and mechanistic studies.
- Selective, allosteric inhibitor of K-Ras(G12C).
- High purity (99.02%).
- Molecular formula C22H31ClF3N3O4S3; molecular weight 590.14.
- Available in small-scale solid quantities and as a 10 mM DMSO solution.
- Suitable for biochemical and cellular assays; for research use only, not for human use.
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES LC-MS TRIFLUOROACETIC ACID50ML
NC2952351 LC-MS TRIFLUOROACETIC ACID50ML
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 10 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein. This product is intended for research use only and is not sold to patients.
- Purity: 98.1%
- Molecular weight: 1661.99 (free base)
- Appearance: Solid
- Color: White to off-white
- Solubility in H2O: 100 mg/mL (ultrasonic needed)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC Dendrotoxin-I (TFA) | 99.9% | 7149.24 | 5 MG
Dendrotoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin has potential for cancer research.
- Potent K+ channel blocker.
- Targets voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6.
- Potential for cancer research.
- Shows significant tumor growth inhibition effect in nude mice with MCF-7 cells when combined with hyperthermia (at 5 mg/kg IV).
Medchemexpress LLC Melittin TFA | 99.85% | 2960.48 | 5 MG
Melittin TFA is a PLA2 activator that stimulates the activity of low molecular weight PLA2. This cytotoxic peptide from bee venom possesses natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also shown diverse anticancer effects by inhibiting cell proliferation, inducing apoptosis, and direct necrosis.
- Cytotoxic peptide from bee venom
- Activates low molecular weight PLA2
- Exhibits anti-bacterial, anti-viral, and anti-inflammatory properties
- Induces apoptosis and necrosis in various cancer cell lines
- Inhibits EGF-induced cell invasion by targeting the PI3K/Akt/mTOR pathway
Medchemexpress LLC Saralasin TFA | 34273-10-4 | 99.18% | 1026.07 | 25 MG
Saralasin TFA, an octapeptide analog of angiotensin II, functions as a competitive angiotensin II receptor antagonist and exhibits partial agonist activity. It is utilized in the research of renovascular hypertension and renin-dependent (angiotensinogenic) hypertension.
- Competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM.
- Exhibits partial agonist activity.
- Inhibits cell growth in 3T3 and SV3T3 cells.
- Restores potassium currents in myocytes.
- Inhibits binding of FITC-Ang II to rat liver membrane preparation.
- Reduces ovulation rate and prostaglandin levels in vitro.
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis in rats.
- Increases serum renin activity in normal, conscious rats.
Waters Corp Proteomics Training Standards, Kit
Waters Corporation Proteomics Training Standards, Kit
Medchemexpress LLC Mazdutide TFA | 99.7% | 4563.06 (free base) | 5 MG
Mazdutide TFA is a long-acting synthetic oxyntomodulin analog that acts as a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). It binds to both human and mouse GCGR and GLP-1R, stimulating insulin secretion from mouse islets. This compound is utilized in research for conditions such as obesity and type 2 diabetes.
- Functions as a co-agonist of GLP-1R and GCGR.
- Binds to human and mouse GCGR and GLP-1R.
- Stimulates insulin secretion from mouse islets.
- Applicable in studies for obesity and type 2 diabetes.
- Significantly reduces body weight and physical intake in diabetic mice with diet-induced obesity.
Medchemexpress LLC D2A21 TFA | >95.6% | 2775.42 | 1 MG
D2A21 TFA is an antimicrobial peptide that exhibits significant activity against Pseudomonas and has a bactericidal effect on burn scabs. This peptide also demonstrates antitumor activity, making it a candidate for research in prostate cancer.
- Antimicrobial peptide
- Active against Pseudomonas
- Bactericidal effect on burn scabs
- Antitumor activity
- Used in prostate cancer research
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384391-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
Medchemexpress LLC LP17 TFA (LQVTDSGLYRCVIYHPP TFA) | 99.2% | 1961.24 | 5 MG
LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. It substantially alleviates ischemia-induced infarction and neuronal injury by accessing the brain and blocking TREM-1. For research use only.
- Decreases mRNA levels of pro-inflammatory cytokines and chemokines.
- Attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model.
- Interacts with microglial SYK.
- Alleviates ischemia-induced infarction and neuronal injury in mice.
- Reduces infarct volume by 27.3%.
- Reduces TUNEL positive cells and FJC positive neurons.
- Rescues neurological deficits and cognitive dysfunction.
- Inhibits microglial M1 polarization and neutrophil infiltration.
Medchemexpress LLC Vm24-toxin (Vaejovis mexicanus peptide 24) | 1373890-79-9 | 3863.59 | 1 MG
Vm24-toxin (Vaejovis mexicanus peptide 24) is a 36-residue peptide that acts as a potent and selective Kv1.3 blocker with a Kd of approximately 3 pM in lymphocytes. It exhibits over 1500-fold higher affinity for Kv1.3 compared to other assayed potassium channels. Vm24-toxin possesses a distorted cystine-stabilized α/β motif, comprising a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. This peptide can attenuate the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation.
- Potent and selective Kv1.3 blocker
- High affinity for Kv1.3 over other potassium channels (>1500-fold)
- Attenuates CD4+ effector memory T cell response to T cell receptor (TCR) stimulation